Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stuart Cockerill"'
Autor:
Richard M. Angell, John Ludes-Meyers, Simon E. Ward, Michael Paradowski, Irina Chuckowree, Alexandre Bedernjak, James Lumley, Carol Villalonga Barber, Kenneth Powell, Edward Littler, Daniel Watterson, Geraldine Taylor, Elaine Thomas, Jose Gascon-Simorte, Mark E. Peeples, Michelle Thom, Jason S. McLellan, Dereck Tait, Neil Mathews, Paul R. Young, Ian M. Fraser, Morgan S.A. Gilman, James A. D. Good, G. Stuart Cockerill, Rachel Harland, Sara M. Johnson, Graham Lunn, Claire Scott, Gareth Williams
RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral. This exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371da7b3d3bd17095117d7ce4913054
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
Autor:
Carter, Malcolm, Stuart Cockerill, G.
Publikováno v:
In Annual Reports in Medicinal Chemistry 2008 43:229-248
Autor:
G. Stuart Cockerill
Publikováno v:
Journal of medicinal chemistry. 63(15)
Inhibitors of the respiratory syncytial virus (RSV) fusion protein block entry of the virus into the cell and have shown varying efficacy in a human challenge model of RSV disease. Trials in patient populations are yet to show significant benefits. J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced63b65549c83d3ae840ca4a1d9e9f2
https://pubmed.ncbi.nlm.nih.gov/32786236
https://pubmed.ncbi.nlm.nih.gov/32786236
Autor:
Young-In Kim, Julie Mori, Rachel Harland, Kenneth Powell, Lynn Wilson, Dereck Tait, Edward Littler, Neil Mathews, Stuart Cockerill, Elaine Thomas, John P. DeVincenzo, John Efthimiou
Publikováno v:
Antimicrobial Agents and Chemotherapy
Effective treatments for respiratory syncytial virus (RSV) infection are lacking. Here, we report a human proof-of-concept study for RV521, a small-molecule antiviral inhibitor of the RSV-F protein. In this randomized, double-blind, placebo-controlle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af34df8cf7d8bf82264b366562353f30
http://europepmc.org/articles/PMC6985722
http://europepmc.org/articles/PMC6985722
Publikováno v:
Journal of Medicinal Chemistry. 62:3206-3227
Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25717f131d07d995c1fbd86b51c04e85
https://doi.org/10.1021/acs.jmedchem.8b01361
https://doi.org/10.1021/acs.jmedchem.8b01361
Tykerb (lapatinib) is a successful medicine for the treatment of a subset of solid tumours driven by aberrant signalling in tumour cells that could be selectively targeted over healthy, normal tissue. The lessons learnt from the discovery and develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1445a2447990211d0d6b3c528ee64335
https://doi.org/10.1039/9781782621836-00676
https://doi.org/10.1039/9781782621836-00676
Autor:
Kimberly G. Petrov, Ann Louise Walker, Yu Guo, Malcolm Clive Carter, David W. Rusnak, Scott Howard Dickerson, Robert A. Mook, Cassandra A. Gauthier, Edgar R. Wood, Karen Lackey, G. Stuart Cockerill, Yue-Mei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4686-4691
Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e36c5b474465ea5bf127c87c05182
https://doi.org/10.1016/j.bmcl.2006.05.090
https://doi.org/10.1016/j.bmcl.2006.05.090
Publikováno v:
Tetrahedron Letters. 40:2601-2604
The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F 2 Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-Miyau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5a73ff9795a4d3e966c51dd14bcb24
https://doi.org/10.1016/s0040-4039(99)00266-x
https://doi.org/10.1016/s0040-4039(99)00266-x
Autor:
Thierry Lequeux, Afshan H. Butt, Howard J. Easterfield, G. Stuart Cockerill, Kevin Blades, Jonathan M. Percy
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3609-3614
Active methylene compounds reacted readily with stable hydrate 2-diethoxyphosphoryl-2,2-difluoroethane-1,1-diol to afford a range of activated alkenes bearing the difluoromethylenephosphonate group, a useful motif in the synthesis of phosphate ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff82b642d19e281e16db6c04e7e0b91
https://doi.org/10.1039/a907052d
https://doi.org/10.1039/a907052d