Výsledky vyhledávání - "Stuart C. Howes"

Visualization of translation and protein biogenesis at the ER membrane

Autor: Max Gemmer, Marten L. Chaillet, Joyce van Loenhout, Rodrigo Cuevas Arenas, Dimitrios Vismpas, Mariska Gröllers-Mulderij, Fujiet A. Koh, Pascal Albanese, Richard A. Scheltema, Stuart C. Howes, Abhay Kotecha, Juliette Fedry, Friedrich Förster

Publikováno v: Nature. 614:160-167

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum (ER) membrane, produces a major fraction of the human proteome1,2. It governs the synthesis, translocation, membrane insertion, N-glycosylation, folding and disulfi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e172198712e11ca47ae175d8a21e7b5
https://doi.org/10.1038/s41586-022-05638-5

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Increased microtubule lattice spacing correlates with selective binding of kinesin-1 in cells

Autor: Leanne de Jager, Klara I. Jansen, Lukas C. Kapitein, Friedrich Förster, Stuart C. Howes

Within the cell cargo is transported via motor proteins walking along microtubules. The affinity of motor proteins for microtubules is controlled by various layers of regulation like tubulin isoforms, post- translational modifications and microtubule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88504052d79c28c2bbf96ac6cff590b
https://hdl.handle.net/1874/428412

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The multi-scale architecture of mammalian sperm flagella and implications for ciliary motility

Autor: Paula Maitan, Bart M. Gadella, Hermes Bloomfield-Gadêlha, Stuart C. Howes, Min Zhang, Heiko Henning, Tzviya Zeev-Ben-Mordehai, Miguel Ricardo Leung, Ravi Teja Ravi, Marc C. Roelofs, Elizabeth G. Bromfield

SummaryMotile cilia are molecular machines used by a myriad of eukaryotic cells to swim through fluid environments. However, available molecular structures represent only a handful of cell types, limiting our understanding of how cilia are modified t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f742a0ef5f5c14f6059a3ea5e5a300e5
https://doi.org/10.1101/2020.11.18.388975

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A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain core

Autor: Ieva Drulyte, Wentao Li, Chunyan Wang, Berend Jan Bosch, Stuart C. Howes, Frank J. M. van Kuppeveld, Daniel L. Hurdiss, Friedrich Förster, Gonzalo Obal, Juliette Fedry

Publikováno v: bioRxiv
biorxiv

SARS-CoV-2 has caused a global outbreak of severe respiratory disease (COVID-19), leading to an unprecedented public health crisis. To date, there has been over thirty-three million diagnosed infections, and over one million deaths. No vaccine or tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1170456971825cf3b5eb3a0a1f2481
https://doi.org/10.1101/2020.09.30.318261

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Structural differences between yeast and mammalian microtubules revealed by cryo-EM

Autor: Elisabeth A. Geyer, Elizabeth H. Kellogg, Rui Zhang, Benjamin LaFrance, Stefan Westermann, Luke M. Rice, Eva Nogales, Stuart C. Howes

Publikováno v: Howes, SC; Geyer, EA; LaFrance, B; Zhang, R; Kellogg, EH; Westermann, S; et al.(2017). Structural differences between yeast and mammalian microtubules revealed by cryo-EM. Journal of Cell Biology, 216(9), 2669-2677. doi: 10.1083/jcb.201612195. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4cq2z3vh
The Journal of cell biology, vol 216, iss 9
The Journal of Cell Biology

Yeast MTs do not appear to undergo the lattice compaction seen in mammalian MTs upon GTP hydrolysis. Binding of the +TIP Bim1, both between and within αβ-tubulin dimers, causes compaction of yeast MTs and their rapid disassembly.
Microtubules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1a580473f400d3e2f30d6261043812
https://doi.org/10.1083/jcb.201612195

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Structural and functional differences between porcine brain and budding yeast microtubules

Autor: Luke M. Rice, Eva Nogales, Benjamin LaFrance, Elisabeth A. Geyer, Stuart C. Howes, Rui Zhang, Elizabeth H. Kellogg, Stefan Westermann

Publikováno v: Cell cycle (Georgetown, Tex.), vol 17, iss 3
Howes, SC; Geyer, EA; LaFrance, B; Zhang, R; Kellogg, EH; Westermann, S; et al.(2018). Structural and functional differences between porcine brain and budding yeast microtubules. Cell Cycle, 17(3), 278-287. doi: 10.1080/15384101.2017.1415680. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/95r0m7j0
Cell Cycle

© 2018 Stuart C. Howes, Elisabeth A. Geyerb, Benjamin LaFrance, Rui Zhang, Elizabeth H. Kellogg, Stefan Westermann, Luke M. Rice and Eva Nogales. Published with license by Taylor & Francis. The cytoskeleton of eukaryotic cells relies on microtubules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b08544f5c4efa6c3cf5a248495c8632
https://escholarship.org/uc/item/95r0m7j0

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Correlative microscopy for structural microbiology

Autor: Abraham J. Koster, Roman I. Koning, Stuart C. Howes

Publikováno v: Current Opinion in Microbiology, 43, 132-138
Current Opinion in Microbiology

Understanding how microbes utilize their environment is aided by visualizing them in their natural context at high resolution. Correlative imaging enables efficient targeting and identification of labelled viral and bacterial components by light micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a7fb938a8ba4d1a2e9217de338b0c
https://pubmed.ncbi.nlm.nih.gov/29414444

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