Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stuart C Wilson"'
Autor:
Simon R Stockwell, Georgina Platt, S Elaine Barrie, Georgia Zoumpoulidou, Robert H Te Poele, G Wynne Aherne, Stuart C Wilson, Peter Sheldrake, Edward McDonald, Mathilde Venet, Christelle Soudy, Frédéric Elustondo, Laurent Rigoreau, Julian Blagg, Paul Workman, Michelle D Garrett, Sibylle Mittnacht
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28568 (2012)
Human cancers often contain genetic alterations that disable G1/S checkpoint control and loss of this checkpoint is thought to critically contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle
Externí odkaz:
https://doaj.org/article/921c0f22c6cd45cb99c4eb1f472162a4
Autor:
Bernard P. Nutley, Florence I. Raynaud, Stuart C. Wilson, Peter M. Fischer, Angela Hayes, Phyllis M. Goddard, Steven J. McClue, Michael Jarman, David P. Lane, Paul Workman
Publikováno v:
Molecular Cancer Therapeutics. 4:125-139
R-roscovitine (seliciclib, CYC202) is a cyclin-dependent kinase inhibitor currently in phase II clinical trials in patients with cancer. Here, we describe its mouse metabolism and pharmacokinetics as well as the identification of the principal metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6039d145160d950d48d9192c3ea6761
https://doi.org/10.1158/1535-7163.125.4.1
https://doi.org/10.1158/1535-7163.125.4.1
Publikováno v:
Tetrahedron Letters. 36:6333-6336
The synthesis of a potential DNA-crosslinking pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) substituted at the C8-position with a 2,3-epoxypropaneoxy moiety using a new cyclization procedure is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd4e4a088c49ca0a3d0735128b28d05
https://doi.org/10.1016/0040-4039(95)01224-6
https://doi.org/10.1016/0040-4039(95)01224-6
Publikováno v:
ChemInform. 26
The synthesis of a potential DNA-crosslinking pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) substituted at the C8-position with a 2,3-epoxypropaneoxy moiety using a new cyclization procedure is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5582b51cdb9d1a88a373a6b8bb250000
https://doi.org/10.1002/chin.199550139
https://doi.org/10.1002/chin.199550139
Autor:
Jonathan J. Turnbull, Ian J. Clifton, Stuart C. Wilson, Richard W.D. Welford, Christopher J. Schofield
Publikováno v:
Organic and biomolecular chemistry. 3(17)
During the biosynthesis of the tricyclic flavonoid natural products in plants, oxidative modifications to the central C-ring are catalysed by Fe(ii) and 2-oxoglutarate dependent oxygenases. The reactions catalysed by three of these enzymes; flavone s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8428a122086ded84096920364be0275
http://ora.ox.ac.uk/objects/uuid:2ce14682-e5f0-45ff-a868-9341be8c4fdf
http://ora.ox.ac.uk/objects/uuid:2ce14682-e5f0-45ff-a868-9341be8c4fdf
Autor:
Lesley J. Adams, Stuart C. Wilson, Stephen M. Forrow, David E. Thurston, Lloyd R. Kelland, Philip W. Howard, Terence C. Jenkins, John A. Hartley
Publikováno v:
Journal of medicinal chemistry. 42(20)
Synthetic routes have been investigated to prepare a novel C8-epoxide-functionalized pyrrolo[2,1-c][1,4]benzodiazepine 6 as a potential sequence-selective DNA cross-linking agent (Wilson et al. Tetrahedron Lett. 1995, 36, 6333-6336). A successful syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290b28613596fbbc34084d4e988ee63c
https://pubmed.ncbi.nlm.nih.gov/10514273
https://pubmed.ncbi.nlm.nih.gov/10514273