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Autor:
Ragnhild A. Lothe, Alan Colman, Rolf Inge Skotheim, Chin Yan Lim, Martin F. Pera, Sharmini Alagaratnam, Paul Robson, Stuart Avery, Peter W. Andrews, Duncan Baker, Barbara B. Knowles, Adam J. Hirst
Publikováno v:
Stem Cell Reports
Summary Human embryonic stem cells (hESCs) regularly acquire nonrandom genomic aberrations during culture, raising concerns about their safe therapeutic application. The International Stem Cell Initiative identified a copy number variant (CNV) amplif
Autor:
Hane Lee, Declan P. Lunny, Ildikó Szeverényi, Sigurd Broesby-Olsen, Mariella D'Alessandro, Anne-Marie Gerdes, Gabriella Pichert, Barry Merriman, Brian O'Connor, Jean Friedel, Stephanie E. Coats, Lesley Christie, Bruno Reversade, Sean Whittaker, David Goudie, E. Birgitte Lane, Chandra S. Verma, Nigel Burrows, Malcolm A. Ferguson-Smith, Ian Hayes, Stuart Avery, Arlene Stewart, Stanley F. Nelson
Publikováno v:
Nature genetics, 43(4), 365-U121. Nature Publishing Group
Goudie, D R, D'Alessandro, M, Merriman, B, Lee, H, Szeverényi, I, Avery, S, O'Connor, B D, Nelson, S F, Coats, S E, Stewart, A, Christie, L, Pichert, G, Friedel, J, Hayes, I, Burrows, N, Whittaker, S, Gerdes, A-M, Broesby-Olsen, S, Ferguson-Smith, M A, Verma, C, Lunny, D P, Reversade, B & Lane, E B 2011, ' Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1 ', Nature Genetics, vol. 43, no. 4, pp. 365-9 . https://doi.org/10.1038/ng.780
Goudie, D R, D'Alessandro, M, Merriman, B, Lee, H, Szeverényi, I, Avery, S, O'Connor, B D, Nelson, S F, Coats, S E, Stewart, A, Christie, L, Pichert, G, Friedel, J, Hayes, I, Burrows, N, Whittaker, S, Gerdes, A-M, Broesby-Olsen, S, Ferguson-Smith, M A, Verma, C, Lunny, D P, Reversade, B & Lane, E B 2011, ' Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1 ', Nature Genetics, vol. 43, no. 4, pp. 365-9 . https://doi.org/10.1038/ng.780
Multiple self-healing squamous epithelioma (MSSE), also known as Ferguson-Smith disease (FSD), is an autosomal-dominant skin cancer condition characterized by multiple squamous-carcinoma-like locally invasive skin tumors that grow rapidly for a few w
Publikováno v:
Stem Cells. 28:863-873
Transforming growth factor (TGF)-β superfamily proteins play a key role in the regulation of human embryonic stem cells (hESCs). Those of the TGFβ/activin/nodal branch seem to support self-renewal and pluripotency, whereas those of the bone morphog
Specific Knockdown of OCT4 in Human Embryonic Stem Cells by Inducible Short Hairpin RNA Interference
Publikováno v:
Stem Cells (Dayton, Ohio)
Manipulation of gene function in embryonic stem cells by either over expression or downregulation is critical for understanding their subsequent cell fate. We have developed a tetracycline-inducible short hairpin RNA interference (shRNAi) for human e
Publikováno v:
Stem Cells and Development. 17:1195-1206
Human embryonic stem cells (hESCs) replicate in vitro by the process of self-renewal, whilst maintaining their pluripotency. Understanding the pathways involved in the regulation of this process will assist in developing fully-defined conditions for
Publikováno v:
Stem Cells and Development. 15:729-740
Human embryonic stem (hES) cells have the ability to self-renew while maintaining their pluripotency. The ability of stem cells to self-renew expansively is essential in both development and maintenance of adult tissues. ES cell lines were first gene
Autor:
James C. Kaufman, Stuart Avery, Virgil E.J.C. Schijns, Winfried D.J. Degen, John R. Young, Lisa Rothwell, Peter K. Kaiser
Publikováno v:
Journal of Interferon & Cytokine Research. 24:600-610
A genomics approach based on the conservation of synteny was used to develop a bacterial artificial chromosome (BAC) contig across the chicken T2 cytokine gene cluster. Sequencing of representative BACs showed that the chicken genome encodes genes fo
Publikováno v:
Developmental & Comparative Immunology. 28:375-394
As the adaptive immune system arose in jawed vertebrates, a reasonable working hypothesis is that cytokines involved exclusively in controlling the adaptive immune system, e.g. T1 and T2 cytokines, will only be found in jawed vertebrates whilst those
Publikováno v:
Biotechnologygenetic engineering reviews. 23