Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stuart Alexander Cook"'
Autor:
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondria
Externí odkaz:
https://doaj.org/article/27de688eb5a24929b14771a4cd8acfce
Autor:
Elisa Rauseo, Muhammad Omer, Alborz Amir-Khalili, Alireza Sojoudi, Thu-Thao Le, Stuart Alexander Cook, Derek John Hausenloy, Briana Ang, Desiree-Faye Toh, Jennifer Bryant, Calvin Woon Loong Chin, Jose Miguel Paiva, Kenneth Fung, Jackie Cooper, Mohammed Yunus Khanji, Nay Aung, Steffen Erhard Petersen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
BackgroundThe quantitative measures used to assess the performance of automated methods often do not reflect the clinical acceptability of contouring. A quality-based assessment of automated cardiac magnetic resonance (CMR) segmentation more relevant
Externí odkaz:
https://doaj.org/article/63ac92b2e79e4062a85744b398e8f625
Autor:
Yasmin Bylstra, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R. Ryanne Wu, Jing Xian Teo, Sonia Davila, Jyn Ling Kuan, Sock Hoai Chan, Nicolas Bertin, Cheng Xi Yang, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Saumya Shekhar Jamuar, Geoffrey S. Ginsburg, Lori A. Orlando, Patrick Tan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background Family history has traditionally been an essential part of clinical care to assess health risks. However, declining sequencing costs have precipitated a shift towards genomics-first approaches in population screening programs rend
Externí odkaz:
https://doaj.org/article/c63732b2d27a4a86a9c0d7a20529368c
Autor:
Thu-Thao Le, Jennifer Ann Bryant, Briana Wei Yin Ang, Chee Jian Pua, Boyang Su, Pei Yi Ho, Shiqi Lim, Weiting Huang, Phong Teck Lee, Hak Chiaw Tang, Chee Tang Chin, Boon Yew Tan, Stuart Alexander Cook, Calvin Woon-Loong Chin
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Objectives The imaging features of dilated cardiomyopathy (DCM) overlap with physiological exercise-induced cardiac remodeling in active and otherwise healthy individuals. Distinguishing the two conditions is challenging. This study examined
Externí odkaz:
https://doaj.org/article/ef3998389983473e8dfe87a941ff0f6a
Autor:
Jonathan Yap, Weng Khong Lim, Anders Sahlén, Calvin Woon-Loong Chin, Kenneth Michael Yun-Chi Chew, Sonia Davila, John Allen, Vera Goh, Swee Yaw Tan, Patrick Tan, Carolyn S. P. Lam, Stuart Alexander Cook, Khung Keong Yeo
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Cardiovascular disease (CVD) imposes much mortality and morbidity worldwide. The use of “deep learning”, advancements in genomics, metabolomics, proteomics and devices like wearables have the potential to unearth new insights
Externí odkaz:
https://doaj.org/article/f54b26d708a747449132327d443a3f1a
Autor:
Wei-Wen Lim, Benjamin Ng, Anissa Widjaja, Chen Xie, Liping Su, Nicole Ko, Sze-Yun Lim, Xiu-Yi Kwek, Stella Lim, Stuart Alexander Cook, Sebastian Schafer
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Externí odkaz:
https://doaj.org/article/b9436e2a31354ff8a067085ea9933b32
Autor:
Yasmin Bylstra, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R. Ryanne Wu, Jing Xian Teo, Sonia Davila, Jyn Ling Kuan, Sock Hoai Chan, Nicolas Bertin, Cheng Xi Yang, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Saumya Shekhar Jamuar, Geoffrey S. Ginsburg, Lori A. Orlando, Patrick Tan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/b547334243994244971a55f64bd83b9f
Autor:
Weng Khong Lim, Sonia Davila, Jing Xian Teo, Chengxi Yang, Chee Jian Pua, Christopher Blöcker, Jing Quan Lim, Jianhong Ching, Jonathan Jiunn Liang Yap, Swee Yaw Tan, Anders Sahlén, Calvin Woon-Loong Chin, Bin Tean Teh, Steven G Rozen, Stuart Alexander Cook, Khung Keong Yeo, Patrick Tan
Publikováno v:
PLoS Biology, Vol 16, Iss 2, p e2004285 (2018)
The use of consumer-grade wearables for purposes beyond fitness tracking has not been comprehensively explored. We generated and analyzed multidimensional data from 233 normal volunteers, integrating wearable data, lifestyle questionnaires, cardiac i
Externí odkaz:
https://doaj.org/article/eebe2bc0e55941b99115b728050458dc
Autor:
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Publikováno v:
Journal of Hepatology. 77:1246-1255
Autor:
Jin Zhou, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Macalinao Dominique Camat, Anne James, Yajun Wu, Jianhong Ching, Jean-Paul Kovalik, Kiat-Hon Lim, Stuart Alexander Cook, Boon-Huat Bay, Brijesh Kumar Singh, Paul Michael Yen
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 32(6)