Výsledky vyhledávání - "Stuart A. Wells"

Bridging conservation across the ex situ‐in situ spectrum: Insights into the reproductive ecology of the threatened narrow‐headed gartersnake ( Thamnophis rufipunctatus )

Autor: Brian R. Blais, Stuart A. Wells, Bradley M. Poynter, Tara R. Harris, Ruth A. Allard, John L. Koprowski

Publikováno v: Zoo Biology. 42:429-439

Zoo-based (ex situ) conservation breeding programs provide invaluable opportunities to uncover enigmatic behaviors and traits of focal species under managed care, which can support research and conservation management efforts. A suite of factors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6907ac04e249c628dc80320e1faf81
https://doi.org/10.1002/zoo.21747

Zobrazit plný text záznamu

Adaptive management in a conservation breeding program: Mimicking habitat complexities facilitates reproductive success in narrow-headed gartersnakes (Thamnophis rufipunctatus)

Autor: Brian R. Blais, Stuart A. Wells, Bradley M. Poynter, John L. Koprowski, Michael M. Garner, Ruth A. Allard

Publikováno v: Zoo biologyREFERENCES. 41(4)

Mimicking natural parameters and complexities in zoo conservation breeding programs can facilitate natural physiological and behavioral traits, which in turn can inform more effective species reintroduction efforts. To curtail population declines of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0f1f92718b3737177b717dbb50eed8
https://pubmed.ncbi.nlm.nih.gov/35037290

Zobrazit plný text záznamu

Lost but not forgotten: MHC genotypes predict overwinter survival despite depauperate MHC diversity in a declining frog

Autor: Taina Torres, Anna E. Savage, Stuart A. Wells, Kevin P. Mulder

Publikováno v: Conservation Genetics. 19:309-322

The amphibian disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has contributed to the decline of Chiricahua leopard frogs (Rana chiricahuensis), a federally threatened species native to the Southwestern United State

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbe3b259d0f735a18aacbbacbe7599b3
https://doi.org/10.1007/s10592-017-1001-3

Zobrazit plný text záznamu

Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis

Autor: John S. Shaw, Martin Wild, Dearg S. Brown, Howard Tucker, Adrian John Highton, Alan Wellington Faull, John Oldfield, John G. Cumming, Colin Fielding, Stuart L. Wells

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:1655-1659

Modifications to a series of potent and selective substituted 1-(3,3-diphenylpropyl)-piperidine phenylacetamide CCR5 antagonists were explored with the aim of reducing affinity at the hERG cardiac ion channel. Replacement of one aromatic ring in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47156f455ebb21c57218d55733038a3
https://doi.org/10.1016/j.bmcl.2011.12.117

Zobrazit plný text záznamu

Dipeptidyl nitrile inhibitors of Cathepsin L

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:4280-4283

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca39a993160acd7584b90a963ada1ade
https://doi.org/10.1016/j.bmcl.2009.05.071

Zobrazit plný text záznamu

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors

Autor: Fredrik Edfeldt, John G. Cumming, Stuart L. Wells, Martin Harrison, Scott G. Lamont, Michael James, Emma Evertsson, Keith Oldham, Jane E. Sullivan, Geoffrey A. Holdgate, Judit E. Debreczeni

Publikováno v: Journal of medicinal chemistry. 58(1)

Two structurally distinct series of novel, MAPK-activated kinase-2 prevention of activation inhibitors have been discovered by high throughput screening. Preliminary structure-activity relationship (SAR) studies revealed substructural features that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7604b0a0aff8f6d931f0a267a4142992
https://pubmed.ncbi.nlm.nih.gov/25255283

Zobrazit plný text záznamu

ChemInform Abstract: Improved Yields of meta-Amination and Symmetrical and Unsymmetrical Diamination of Benzenes

Autor: Brown George Robert, Robin Wood, Craig A. Roberts, Alan J. Foubister, Stuart L. Wells

Publikováno v: ChemInform. 32

Much higher yields were found after shorter reaction times for the meta -substituted amination of benzenes in DMPU with microwave heating in a sealed tube (180°C, 5 h), e.g. piperidine and m -fluorobenzonitrile 1 gave the m -substituted 3 in 92% yie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68e51bd900f4d85c5cbbe0d26c84f51e
https://doi.org/10.1002/chin.200135080

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání