Zobrazeno 1 - 10
of 576
pro vyhledávání: '"Stuart A. Aaronson"'
Autor:
Davide Esposito, Ila Pant, Yao Shen, Rui F. Qiao, Xiaobao Yang, Yiyang Bai, Jian Jin, Poulikos I. Poulikakos, Stuart A. Aaronson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Crosstalk between the p53 and Hippo pathway has been reported in different physiological contexts. Here, the authors show that p53 DNA contact mutations upregulate TEAD/YAP transcription indirectly and transform cells via hyperactivation of RhoA/ROCK
Externí odkaz:
https://doaj.org/article/62adbf8756394be3b9ead238d98050fa
Autor:
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and
Externí odkaz:
https://doaj.org/article/178a7e049b6748368cce8de609f3ab95
Autor:
Linh T. Vuong, Carlo Iomini, Sophie Balmer, Davide Esposito, Stuart A. Aaronson, Marek Mlodzik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and
Externí odkaz:
https://doaj.org/article/7893223fd93f4dcbba5c114000984a9d
Autor:
Sathish Kumar Mungamuri, Rui F. Qiao, Shen Yao, James J. Manfredi, Wei Gu, Stuart A. Aaronson
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2528-2537 (2016)
The H3K9me3 repressive histone conformation of p53 target promoters is abrogated in response to p53 activation by MDM2-mediated SUV39H1 degradation. Here, we present evidence that the USP7 deubiquitinase protects SUV39H1 from MDM2-mediated ubiquitina
Externí odkaz:
https://doaj.org/article/dbd096add3d943fcaed52a669ff3be6d
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 302-313 (2013)
ErbB2 gene amplification occurs in 20%–25% of breast cancers, and its therapeutic targeting has markedly improved survival of patients with breast cancer in the adjuvant setting. However, resistance to these therapies can develop. Because epigeneti
Externí odkaz:
https://doaj.org/article/d7269b25d1f744fcb03197617faa83d6
Publikováno v:
Viruses, Vol 2, Iss 1, Pp 298-313 (2010)
Tumor suppressor p53 is widely known as ‘the guardian of the genome’ due to its ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. However, recent studies indicate that p53 is also a direct
Externí odkaz:
https://doaj.org/article/3bc228046ee14cebbf235e680374033d
Autor:
Luca Grumolato, Stuart A. Aaronson
Publikováno v:
Holland‐Frei Cancer Medicine. :1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad37c7e86ef1ec03fe5a8f9866d8b3d
https://doi.org/10.1002/9781119000822.hfcm010.pub2
https://doi.org/10.1002/9781119000822.hfcm010.pub2
Autor:
David J Mulholland, Shu-Hsia Chen, Stuart A Aaronson, Emanuela Taioli, Ping-Ying Pan, Ronald E Gordon, Kensey Portman, Andriy Kobryn, Kyeongah Kang, Licheng Zhang, Yitian Xu, Lin Wang
Fig. S3. A-B, Expression of P-AKT-S473 in the prostatic acini from WTC dust treated Pb-Cre+PtenL/Wt mice shown at low and high magnifications (A = early progression, B = later progression). C, P-AKT-S473 expression in Pb-Cre+PtenL/L GEM mice (HE bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d89db201d1723023cb747f5883c272
https://doi.org/10.1158/2767-9764.22544754.v1
https://doi.org/10.1158/2767-9764.22544754.v1
Autor:
David J Mulholland, Shu-Hsia Chen, Stuart A Aaronson, Emanuela Taioli, Ping-Ying Pan, Ronald E Gordon, Kensey Portman, Andriy Kobryn, Kyeongah Kang, Licheng Zhang, Yitian Xu, Lin Wang
During the 9/11 attacks, individuals were exposed to World Trade Center (WTC) dust which contained a complex mixture of carcinogens. Epidemiologic studies have revealed the increased incidence of prostate and thyroid cancer in WTC survivors and respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6803027a8062e2c298ab110c1bf53d
https://doi.org/10.1158/2767-9764.c.6550740.v1
https://doi.org/10.1158/2767-9764.c.6550740.v1
Autor:
Poulikos I. Poulikakos, David E. Shaw, Qi Wang, Meenhard Herlyn, Avner Schlessinger, Brian D. Brown, Vito W. Rebecca, Celina Ang, Stuart A. Aaronson, Xuewei Wu, Angelo Amabile, Zoi Karoulia, Min Xiao, Peter M.U. Ung, Maxwell R. Tucker, Tamer A. Ahmed, Christos Adamopoulos
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e30c7b1b59cf5578370905338ebbd54
https://doi.org/10.1158/2159-8290.22540393.v1
https://doi.org/10.1158/2159-8290.22540393.v1