Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Stuart A Nicklin"'
Autor:
Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004673 (2015)
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX)
Externí odkaz:
https://doaj.org/article/6ac6df5e8e0a463095cf3f42d8085f51
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45564 (2012)
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor. Furthermore, we recently reported that an alt
Externí odkaz:
https://doaj.org/article/55109ab1ea9247609f618e782902a83d
Autor:
Angela C Bradshaw, Alan L Parker, Margaret R Duffy, Lynda Coughlan, Nico van Rooijen, Veli-Matti Kähäri, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001142 (2010)
Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown. Upon contact with blood, vectors based on adenovirus serotype 5 (Ad5) binds to FX via the hexon
Externí odkaz:
https://doaj.org/article/d0627ccd171b4c2f9e6d275e4aeddb5b
Autor:
Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K Lee, Davide Gentilini, Claire E Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M C Connell, Morris Brown, Nilesh J Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H Erich Wichmann, Maris Laan, David P Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D Spector, Gavin Lucas, Sekar Kathiresan, David S Siscovick, Jian'an Luan, Ruth J F Loos, Nicholas J Wareham, Brenda W Penninx, Ilja M Nolte, Martin McBride, William H Miller, Stuart A Nicklin, Andrew H Baker, Delyth Graham, Robert A McDonald, Jill P Pell, Naveed Sattar, Paul Welsh, Global BPgen Consortium, Patricia Munroe, Mark J Caulfield, Alberto Zanchetti, Anna F Dominiczak
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001177 (2010)
Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existen
Externí odkaz:
https://doaj.org/article/57807fab5b1d4659bc82c7a7a71fbacc
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
Autor:
Emily A. Bates, John R. Counsell, Sophie Alizert, Alexander T. Baker, Natalie Suff, Ashley Boyle, Angela C. Bradshaw, Simon N. Waddington, Stuart A. Nicklin, Andrew H. Baker, Alan L. Parker
Publikováno v:
Viruses, Vol 13, Iss 8, p 1483 (2021)
The human adenovirus phylogenetic tree is split across seven species (A–G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of pre-existing immunity detected across screened populations. However, many
Externí odkaz:
https://doaj.org/article/b185ff6201cc438789403464eeb6d6d7
Autor:
Gillian A. Gray, Stuart A. Nicklin, Tamara P. Martin, Ali Abdullah I. Zaeri, Dylan O'Toole, Eilidh A MacDonald, Ali Ali Mohamed Elbassioni, Christopher M. Loughrey
Publikováno v:
Martin, T P, Macdonald, E A, Elbassioni, A A M, O'toole, D, Zaeri, A A I, Nicklin, S A, Gray, G A & Loughrey, C M 2021, ' Preclinical models of myocardial infarction: from mechanism to translation ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15595
Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Preclinical animal models have significantl
Autor:
Elspeth B. Elliott, Aadil Shaukat, Weihong He, Kristopher Ford, Lisa McArthur, Katrin Nather, Mitchell Lindsay, Colin Berry, Stuart Hood, Ali Abdullah I. Zaeri, Catherine Hawksby, Tamara P. Martin, John D. McClure, Keith G. Oldroyd, David Carrick, Paul Rocchiccioli, Hany Eteiba, Keith M. Channon, Andrew Davie, Dylan O'Toole, Margaret McEntegart, Mark C. Petrie, Kenneth Mangion, Charlotte S. McCarroll, Stuart Watkins, Mathew M Y Lee, Stuart A. Nicklin, David Corcoran, Christopher M. Loughrey, Richard Good, Alexandra Riddell, Godfrey L. Smith
Publikováno v:
Cardiovascular Research. 118:1535-1547
Aims: \ud Identifying novel mediators of lethal myocardial reperfusion injury that can be targeted during primary percutaneous coronary intervention (PPCI) is key to limiting the progression of patients with ST-elevated myocardial infarction (STEMI)
Autor:
Stuart A. Nicklin, Christopher M. Loughrey, Ewan R. Cameron, Tamara P. Martin, Thomas Braun, Alexandra Riddell, Martin W. McBride
Publikováno v:
Cardiovascular Research
Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in multiple s
In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications
Autor:
Angela C. Bradshaw, Sophie Alizert, Emily A. Bates, Simon N. Waddington, Natalie Suff, Ashley Boyle, Stuart A. Nicklin, Andrew H. Baker, Alan L. Parker, Alexander T. Baker, John R. Counsell
Publikováno v:
Bates, E A, Counsell, J R, Alizert, S, Baker, A T, Suff, N, Boyle, A, Bradshaw, A C, Waddington, S N, Nicklin, S A, Baker, A H & Parker, A L 2021, ' In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications ', Viruses, vol. 13, no. 8, pp. 1483 . https://doi.org/10.3390/v13081483
Viruses, Vol 13, Iss 1483, p 1483 (2021)
Viruses
Volume 13
Issue 8
Viruses, Vol 13, Iss 1483, p 1483 (2021)
Viruses
Volume 13
Issue 8
The human adenovirus phylogenetic tree is split across seven species (A–G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of pre-existing immunity detected across screened populations. However, many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3092d7d8c1ec6b312dea4f028b61a08
https://eprints.gla.ac.uk/248574/1/248574.pdf
https://eprints.gla.ac.uk/248574/1/248574.pdf
Autor:
Wendy Beattie, Augusto C. Montezano, Livia L Camargo, Rheure A Lopes, Stuart A. Nicklin, Karla B Neves, Colin Berry, Rhian M. Touyz, Francisco J. Rios
Publikováno v:
The FASEB Journal
Introduction COVID‐19 is primarily a respiratory disease associated with cardiovascular risk. SARS‐CoV‐2, the virus causing COVID‐19, uses ACE2, an important enzyme in the cardiovascular system that regulates the conversion of Ang II (deleter