Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Stuart A Grossman"'
Autor:
Nickolas Papadopoulos, Chen Hu, Julie R Brahmer, Patrick M Forde, Evan J Lipson, Jarushka Naidoo, Wei Fu, Joanne Riemer, Chetan Bettegowda, Cesar A Santa-Maria, Matthias Holdhoff, Amanda Barnes, Nafi Aygun, Lawrence Kleinberg, Christopher Douville, Arun Venkatesan, Karisa C Schreck, Alexander Carvajal-Gonzalez, Roisin M Connolly, Kristin J Redmond, Brandi Page, Kenneth W Kinzler, Stuart A Grossman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown.Methods We undertook a phase II trial of pembrolizumab in patients with LMM from solid tumors. Eligible patients had radiologic/
Externí odkaz:
https://doaj.org/article/5144d6053e5e4af9b489cd9937834ab8
Autor:
Anna F Piotrowski, Stuart A Grossman
Publikováno v:
Glioma, Vol 2, Iss 1, Pp 3-6 (2019)
Treatment-related lymphopenia is a poor prognostic factor for overall survival in patients with high-grade glioma and predicts suboptimal response to immune therapies. Immunotherapy is conceptually an appealing approach in adults with high-grade glio
Externí odkaz:
https://doaj.org/article/673045f055144a0a9100e3d0cf14b9d2
Autor:
Paola Ghanem, Maria Fatteh, David Olayinka Kamson, Archana Balan, Michael Chang, Jessica Tao, Jaishri Blakeley, The Johns Hopkins Molecular Tumor Board Investigators, Jenna Canzoniero, Stuart A. Grossman, Kristen Marrone, Karisa C. Schreck, Valsamo Anagnostou, Christine Pratilas, Taxiarchis Botsis, Rena Xian, Chris Gocke, Tseh Ming-Lin, Eitan Halper-Stromberg, Ying Zou, Kent Hardart, Jonathan Spiker, Kory Kreimeyer, Ting He, Katie Fiallos, Dana Petry, Kala Visvanathan, Antonio Wolff, Cesar Santa-Maria, Raquel Nunez, Christian Meyer, John Laterra, Vered Stearns, Karen Smith, Deborah Armstrong, Rachel Karchin, Katerina Karaindrou, Lily Zandi, Marta Majcherska, Faith Too, Monique Makell, Jennifer Lehman, Timsy Wanchoo, Jaime Wehr, Michael Conroy, Selina Shiqing Teh.
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundDespite the putatively targetable genomic landscape of high-grade gliomas, the long-term survival benefit of genomically-tailored targeted therapies remains discouraging.MethodsUsing glioblastoma (GBM) as a representative example of high-gr
Externí odkaz:
https://doaj.org/article/5bcfd0838b504f0dae83f9e83188528c
Autor:
David O. Kamson, Viveka Chinnasamy, Stuart A. Grossman, Chetan Bettegowda, Peter B. Barker, Peter W. Stacpoole, Georg Oeltzschner
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The adverse effects of lactic acidosis in the cancer microenvironment have been increasingly recognized. Dichloroacetate (DCA) is an orally bioavailable, blood brain barrier penetrable drug that has been extensively studied in the treatment of mitoch
Externí odkaz:
https://doaj.org/article/51eac7b3710246fe9d1c769f082fc196
Autor:
Sadhana Jackson, Jon Weingart, Edjah K. Nduom, Thura T. Harfi, Richard T. George, Dorothea McAreavey, Xiaobu Ye, Nicole M. Anders, Cody Peer, William D. Figg, Mark Gilbert, Michelle A. Rudek, Stuart A. Grossman
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Background The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB disruption and in
Externí odkaz:
https://doaj.org/article/38bb304a8ef54edb86d7eee7cfa253e3
Publikováno v:
Current Neuropharmacology. 20:1383-1399
Background: The blood-brain barrier inhibits the central nervous system penetration of 98% of small molecule drugs and virtually all biologic agents, which has limited progress in the treatment of neurologic disease. Vasoactive peptides have been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91df567f7e1786a11c74e0b6db25bc1
https://doi.org/10.2174/1570159x20999220131163504
https://doi.org/10.2174/1570159x20999220131163504
Autor:
Xiaobu Ye, Serena Desideri, Ignacio Garcia Ribas, April Eichler, L. Burt Nabors, Manmeet S. Ahluwalia, Myrna R. Rosenfeld, Tom Mikkelsen, Andrew S. Chi, Stuart A. Grossman, Jaishri O. Blakeley
Supplementary Table 1 from Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd16a011855237989e70b221e8a139f
https://doi.org/10.1158/1078-0432.22473791
https://doi.org/10.1158/1078-0432.22473791
Autor:
Xiaobu Ye, Serena Desideri, Ignacio Garcia Ribas, April Eichler, L. Burt Nabors, Manmeet S. Ahluwalia, Myrna R. Rosenfeld, Tom Mikkelsen, Andrew S. Chi, Stuart A. Grossman, Jaishri O. Blakeley
Purpose:Iniparib is a purported prodrug causing cell death through intracellular conversion to nitro radical ions. We assessed the efficacy and safety of iniparib with standard radiotherapy and temozolomide in patients with newly diagnosed glioblasto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe74e8c0343ff636c1fd2e0e9eced66
https://doi.org/10.1158/1078-0432.c.6528608.v1
https://doi.org/10.1158/1078-0432.c.6528608.v1
Autor:
David O. Kamson, Debraj Mukherjee, Adham M. Khalafallah, Lawrence Kleinberg, Carlos G Romo, Stuart A. Grossman, Henry Brem, Jon D. Weingart, Adrian E. Jimenez
Publikováno v:
Journal of Neurosurgery. 135:87-92
OBJECTIVE There has been limited research on the efficacy of multidisciplinary tumor boards (MDTBs) in improving the treatment of patients with tumors affecting the nervous system. The objective of the present study was to quantify the utility of MDT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feacc45a74732d11b1a45a60b5840f1
https://doi.org/10.3171/2020.5.jns201299
https://doi.org/10.3171/2020.5.jns201299
Publikováno v:
Neurooncol Pract
AbstractTargeted therapy has gained mainstream attention with notable successes against specific genetic mutations in many cancers. One particular mutation, the BRAF V600E mutation, is present in a small subset of gliomas in adults. Although clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd754e8c99c727ea3ef7c9550db7523b
https://doi.org/10.1093/nop/npaa006
https://doi.org/10.1093/nop/npaa006