A microphysiological system for studying barrier health of live tissues in real time

Autor: Ryan Way, Hayley Templeton, Daniel Ball, Ming-Hao Cheng, Stuart A. Tobet, Thomas Chen

Publikováno v: Communications Engineering, Vol 3, Iss 1, Pp 1-12 (2024)

Abstract Epithelial cells create barriers that protect many different components in the body from their external environment. Increased gut barrier permeability (leaky gut) has been linked to several chronic inflammatory diseases. Understanding the c

Externí odkaz: https://doaj.org/article/a94018e6f156483cadf35cd4707d1fab

Sex differences in anatomic plasticity of gut neuronal–mast cell interactions

Autor: Luke A. Schwerdtfeger, Stuart A. Tobet

Publikováno v: Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)

Abstract The gut wall houses mast cells that are anatomically situated near enteric neuronal fibers. Roles of specific neuropeptides in modulating function of immune components like mast cells in response to challenge with bacterial components are re

Externí odkaz: https://doaj.org/article/bcf468fdf65c4dfa936f34b427703441

1H-NMR Profiling of Short-Chain Fatty Acid Content from a Physiologically Accurate Gut-on-a-Chip Device

Autor: Brandaise Martinez, Luke A. Schwerdtfeger, Alec Richardson, Stuart A. Tobet, Charles S. Henry

Publikováno v: Analytical Chemistry. 94:9987-9992

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e348d07a290bcca7c20780d4098c7132
https://doi.org/10.1021/acs.analchem.1c05146

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Autor: Andreas J. Forstner, Martin Alda, Manolis Kogevinas, Pak C. Sham, Patrick F. Sullivan, Michele T. Pato, John R. Kelsoe, Paul A. Tooney, Steven P. Hamilton, Dorret I. Boomsma, Gerome Breen, Tracy Air, Hannelore Ehrenreich, Nakao Iwata, Jill M. Goldstein, Olav B. Smeland, Daniel R. Weinberger, Andrew McQuillin, Stuart A. Tobet, Elvira Bramon, Gabriëlla A.M. Blokland, Jing Qin Wu, Erik G. Jönsson, Peter R. Schofield, Fabian Streit, Nicholas Bass, Aarno Palotie, Brian Kelly, Cathryn M. Lewis, Srdjan Djurovic, Thomas Damm Als, Chia-Yen Chen, Bettina Konte, Joanna Hauser, Claire O'Donovan, Laura J. Scott, Hans J. Grabe, Murray J. Cairns, Rudolf Uher, Pablo Cervantes, Nicholas G. Martin, James A. Knowles, Aiden Corvin, Espen Molden, Lili Milani, Andreas Reif, Maria Grigoroiu-Serbanescu, George Kirov, Yuri Milaneschi, David St Clair, Eco J. C. de Geus, Robert Handa, Tõnu Esko, Alexander Teumer, Anders D. Børglum, Divya Mehta, Roel A. Ophoff, Susanne Lucae, Henning Tiemeier, Marion Leboyer, Ina Giegling, Alan R. Sanders, Jouke-Jan Hottenga, Pablo V. Gejman, Bernhard T. Baune, Brenda W.J.H. Penninx, Chris Cotsapas, Martin Preisig, Thomas Werge, Jakob Grove, Ingrid Melle, Jordan W. Smoller, Marcella Rietschel, Myrna M. Weissman, Preben Bo Mortensen, Philip B. Mitchell, Jolanta Lissowska, Andrew M. McIntosh, Annette M. Hartmann, Ole A. Andreassen, Lea Sirignano, John B. Vincent, Niamh Mullins, Jimmy Lee, Gonneke Willemsen, Marian L. Hamshere, Rolf Adolfsson, Mark A. Frye, Markus M. Nöthen, Jianxin Shi, Ashley L. Comes, Robin M. Murray, Patrik K. E. Magnusson, Frank Bellivier, Stéphane Jamain, Ole Mors, Sven Cichon, Uwe Völker, Fermín Mayoral, Bryan J. Mowry, Bruno Etain, James B. Potash, Beata Świątkowska, Bertram Müller-Myhsok, Mikael Landén, Tracey L. Petryshen, Franziska Degenhardt, Mark Adams, Dan Rujescu, Jose Guzman-Parra, Thomas G. Schulze, Merete Nordentoft, Joseph D. Buxbaum, Janice M. Fullerton, Brien P. Riley, Roy H. Perlis, Arne E. Vaaler, David M. Hougaard, Eli A. Stahl, Susan L. McElroy, Sabrina K. Schaupp, Martin Begemann, Sandra Van der Auwera, Todd Lencz, Joanna M. Biernacka, Agnes A. Steixner-Kumar, Douglas F. Levinson, Sathish Periyasamy, Alexander Viktorin, Anil K. Malhotra

BACKGROUNDSex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d686581dfcd119640e9f174fe59ed5f
https://www.ncbi.nlm.nih.gov/pubmed/34099189

A microfluidic organotypic device for culture of mammalian intestinesex vivo

Autor: Diana Eaton, Charles S. Henry, Ian Mclean, Luke A. Schwerdtfeger, Stuart A. Tobet, Alec Richardson

Publikováno v: Analytical Methods. 12:297-303

The physiological characteristics of the gastrointestinal (GI) tract are diverse and include rapid rates of epithelial turnover, complex nervous and immune systems, a thick mucus layer, and a large microbial population. Most GI models in vitro rely u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd1c6f5d197590eec13775df3cfa23fb
https://doi.org/10.1039/c9ay02038a