Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Stuart A, Ralph"'
Autor:
Emma McHugh, Michaela S. Bulloch, Steven Batinovic, Cameron J. Patrick, Drishti K. Sarna, Stuart A. Ralph
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional r
Externí odkaz:
https://doaj.org/article/f970a0b75e754aad8d5c1abc6f26484e
Autor:
Simon A Cobbold, Madel V Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp 1-20 (2021)
Abstract The malaria parasite, Plasmodiumfalciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sources and essential nutrients from its host cell. However, a global overview of the metabolic capacity of intraer
Externí odkaz:
https://doaj.org/article/85219461186340c79d8c14ae42b6810f
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001638 (2022)
Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture.
Externí odkaz:
https://doaj.org/article/9d986d7e399b48999d07565816c1089f
Autor:
Benjamin Liffner, Sonja Frölich, Gary K. Heinemann, Boyin Liu, Stuart A. Ralph, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Rhoptries are essential organelles for invasion of erythrocytes by Plasmodium. Here, the authors characterize the rhoptry-associated protein CERLI1 using quantitative super-resolution microscopy, showing that it is important for parasite invasion and
Externí odkaz:
https://doaj.org/article/70c3ecfb941c4e2fb2554ab17a4f110b
Autor:
Andreas J. Stroehlein, Pasi K. Korhonen, V. Vern Lee, Stuart A. Ralph, Margaret Mentink-Kane, Hong You, Donald P. McManus, Louis-Albert Tchuem Tchuenté, J. Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M. Emery, Bonnie L. Webster, Paul J. Brindley, David Rollinson, Bill C. H. Chang, Robin B. Gasser, Neil D. Young
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2 (2022)
Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenita
Externí odkaz:
https://doaj.org/article/fefe19173810481c8b859d7a47f4f70f
Autor:
Lee M. Yeoh, Christopher D. Goodman, Vanessa Mollard, Emma McHugh, V. Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I. McFadden, Stuart A. Ralph
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles. The role of al
Externí odkaz:
https://doaj.org/article/0c722fb05a7d496aab4e3d26b383f8b9
Autor:
V. Vern Lee, Louise M. Judd, Aaron R. Jex, Kathryn E. Holt, Christopher J. Tonkin, Stuart A. Ralph
Publikováno v:
mSystems, Vol 6, Iss 2 (2021)
ABSTRACT Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the gene product. However, this has been poorly characterized in apicomplexans, a major phylum of some of the most im
Externí odkaz:
https://doaj.org/article/5e6e2bd160d641ada2a753d8ee4b707c
Autor:
Ameya Sinha, Sebastian Baumgarten, Amy Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M. Bryant, Jiaqi Liang, Germano Cecere, Peter C. Dedon, Peter R. Preiser, Stuart A. Ralph, Artur Scherf
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Infection with the unicellular eukaryotic pathogen Plasmodium falciparum
Externí odkaz:
https://doaj.org/article/6a4838d372414cd098219b2fa7597358
Autor:
Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and
Externí odkaz:
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background The clinical symptoms of malaria are caused by the asexual replication of Plasmodium parasites in the blood of the vertebrate host. To spread to new hosts, however, the malaria parasite must differentiate into sexual forms, termed
Externí odkaz:
https://doaj.org/article/f76e78041ab94757b0e61b808507900c