Zobrazeno 1 - 10
of 703
pro vyhledávání: '"Stuart A, Cook"'
Autor:
Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Fathima F. Kuthubudeen, Yu-Ning Liu, An An Hii, Benjamin L. George, Anissa A. Widjaja, Enrico Petretto, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human i
Externí odkaz:
https://doaj.org/article/07484aadbfc741bd92d4fb8436b32283
Autor:
Vivian Lee, Qishi Zheng, Desiree-Faye Toh, Chee Jian Pua, Jennifer A. Bryant, Chi-Hang Lee, Stuart A. Cook, Javed Butler, Javier Díez, A. Mark Richards, Thu-Thao Le, Calvin W. L. Chin
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundDiffuse interstitial myocardial fibrosis is a key common pathological manifestation in hypertensive heart disease (HHD) progressing to heart failure (HF). Angiotensin receptor–neprilysin inhibitors (ARNi), now a front-line treatment for H
Externí odkaz:
https://doaj.org/article/1b177e2affe24770b9f07cf919337730
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Repair processes in kidney are impaired in severe disease. Here, the authors show that in kidney failure, genetic or pharmacologic inhibition of IL11 releases the brake on regeneration, reverses tissue damage and restores kidney function.
Externí odkaz:
https://doaj.org/article/60e0f4d907fc4280bc1f88c1b900af64
Autor:
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondria
Externí odkaz:
https://doaj.org/article/27de688eb5a24929b14771a4cd8acfce
Autor:
Anissa A. Widjaja, Stuart A. Cook
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1363 (2024)
IL6 is a proinflammatory cytokine that binds to membrane-bound IL6 receptor (IL6R) or soluble IL6R to signal via gp130 in cis or trans, respectively. We tested the hypothesis that sgp130Fc, which is believed to be a selective IL6 trans-signalling inh
Externí odkaz:
https://doaj.org/article/9716bd1f473b4e3ca452492c453354d8
Autor:
Mark Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul J. R. Barton, Stuart A. Cook
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12989 (2023)
Cardiac fibrosis is a common pathological process in heart disease, representing a therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac fibrosis and was recently shown to be dependent on interleukin 11 (IL11) f
Externí odkaz:
https://doaj.org/article/5a4e1e9a585e4eca9f4a8405f740f804
Autor:
Emanuele F. Osimo, Mark Sweeney, Antonio de Marvao, Alaine Berry, Ben Statton, Benjamin I. Perry, Toby Pillinger, Thomas Whitehurst, Stuart A. Cook, Declan P. O’Regan, E. Louise Thomas, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Cardiovascular diseases are the leading cause of death in schizophrenia. Patients with schizophrenia show evidence of concentric cardiac remodelling (CCR), defined as an increase in left-ventricular mass over end-diastolic volumes. CCR is a
Externí odkaz:
https://doaj.org/article/5831c44a2ba848ddabcf4d09d8406aba
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model
Autor:
David Schumacher, Elisa A. Liehn, Pakhwan Nilcham, David Castaño Mayan, Chutima Rattanasopa, Kaviya Anand, Gustavo E. Crespo-Avilan, Sauri Hernandez-Resendiz, Roshni R. Singaraja, Stuart A. Cook, Derek J. Hausenloy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Vascular restenosis remains a major problem in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). Neointimal hyperplasia, defined by post-procedure proliferation and migration of vascular smooth muscle cells (VS
Externí odkaz:
https://doaj.org/article/2cdabc40b84c435688af1cffde7a4c71
Autor:
Thu-Thao Le, PhD, Benjamin Huang, MD, Chee Jian Pua, PhD, Vineet Tornekar, MD, Annette Schumacher-Maurer, MD, Desiree-Faye Toh, MSc, Jennifer Bryant, PhD, Briana Ang, BSc, Ben Corden, PhD, Sanjay K. Prasad, MD, Hak-Chiaw Tang, MBBS, Stuart A. Cook, MD, PhD, Calvin W.L. Chin, MD, PhD
Publikováno v:
JACC: Asia, Vol 1, Iss 2, Pp 218-226 (2021)
Background: Hypertrophic cardiomyopathy (HCM) is defined as left ventricular end-diastolic maximal wall thickness (WTMax) ≥15.0 mm, without accounting for ethnicity, sex, and body size. It is well-established that Asians have smaller hearts than do
Externí odkaz:
https://doaj.org/article/8d800728bfbd47f0ba5108a6c13f1a7f
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104806- (2022)
Summary: IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428
Externí odkaz:
https://doaj.org/article/07ef08c66326440fbef0269cb7059dcd