Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Stuart A, Cain"'
Autor:
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-t
Externí odkaz:
https://doaj.org/article/7f60fbce64114253a4fc70c967d52dd5
Autor:
Dan L. McElroy, Andrew J. Roebuck, Quentin Greba, Sumanta Garai, Asher L. Brandt, Orhan Yilmaz, Stuart M. Cain, Terrance P. Snutch, Ganesh A. Thakur, Robert B. Laprairie, John G. Howland
Publikováno v:
IBRO Neuroscience Reports, Vol 12, Iss , Pp 121-130 (2022)
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5–5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG). Curr
Externí odkaz:
https://doaj.org/article/b926279b3de946e6b0d7bbfc1871a059
Autor:
Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina Dadachova
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 979 (2023)
Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we exa
Externí odkaz:
https://doaj.org/article/c4e817e3f39f4e6b99757ca74f03bafa
Autor:
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte
Publikováno v:
eLife, Vol 11 (2022)
The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur
Externí odkaz:
https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524
Autor:
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Clair Baldock
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin. LTBP4 mutations are linked to autosomal r
Externí odkaz:
https://doaj.org/article/0d2bc83f21614a69a28db224a7269c76
Autor:
Jazmin Ozsvar, Chengeng Yang, Stuart A. Cain, Clair Baldock, Anna Tarakanova, Anthony S. Weiss
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the majority of elastic fibers and is formed by the hierarchical assemb
Externí odkaz:
https://doaj.org/article/f0fa795527ff4c68bba944875c4e430e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin (“gabapentinoids”) were engineered to mimic the action of GABA and to modulate GABA metabolism. Rather than their intended pharmacological action on GABA neur
Externí odkaz:
https://doaj.org/article/02cb45047369467fb6fbd31197ca8032
Publikováno v:
Matrix Biology. 114:18-34
The ADAMTS superfamily is composed of secreted metalloproteases and structurally related non-catalytic ADAMTS-like proteins. A subset of this superfamily, including ADAMTS6, ADAMTS10 and ADAMTSL2, are involved in elastic fiber assembly and bind to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fa0b1a005fe9d14fd37ff66f58f8c8
https://doi.org/10.1016/j.matbio.2022.11.001
https://doi.org/10.1016/j.matbio.2022.11.001
Autor:
Dadachova, Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 979
Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::8453329f586d7aac5a60772c05fe3d85
Autor:
Jordan J. Shimell, Bhavin S. Shah, Stuart M. Cain, Samrat Thouta, Naila Kuhlmann, Igor Tatarnikov, D. Blair Jovellar, G. Stefano Brigidi, Jennifer Kass, Austen J. Milnerwood, Terrance P. Snutch, Shernaz X. Bamji
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2422-2437.e8 (2019)
Summary: Palmitoylation is a reversible post-translational lipid modification that facilitates vesicular transport and subcellular localization of modified proteins. This process is catalyzed by ZDHHC enzymes that are implicated in several neurologic
Externí odkaz:
https://doaj.org/article/fb1d68dc9602431a9df8d9734febf116