mARC1 Is the Main Contributor to Metabolic Reduction of N -Hydroxyurea.

Autor: Klopp C; Zoological Institute - Structural Biology, Kiel University 24118, Kiel, Germany.; Pharmaceutical Institute - Medicinal Chemistry, Kiel University 24118, Kiel, Germany., Zhang X; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States., Campbell MK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States., Kvaskoff D; Department of Drug Discovery Sciences, Discovery Science Technologies (DK, BB), Boehringer Ingelheim Pharma GmbH & Co. 88400, Biberach an der Riss, Germany., Struwe MA; Zoological Institute - Structural Biology, Kiel University 24118, Kiel, Germany.; Pharmaceutical Institute - Medicinal Chemistry, Kiel University 24118, Kiel, Germany., Warren CR; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States., Bajrami B; Department of Drug Discovery Sciences, Discovery Science Technologies (DK, BB), Boehringer Ingelheim Pharma GmbH & Co. 88400, Biberach an der Riss, Germany., Scheidig AJ; Zoological Institute - Structural Biology, Kiel University 24118, Kiel, Germany., Jones AK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States., Clement B; Pharmaceutical Institute - Medicinal Chemistry, Kiel University 24118, Kiel, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18090-18097. Date of Electronic Publication: 2024 Oct 13.

mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.

Autor: Jones AK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Bajrami B; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Campbell MK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Erzurumluoglu AM; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Guo Q; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Chen H; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Zhang X; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Zeveleva S; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Kvaskoff D; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Brunner AD; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Muller S; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Gathey V; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Dave RM; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Tanner JW; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Rixen S; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany., Struwe MA; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany.; Department of Biology, Institute of Zoology-Structural Biology, Christian Albrechts University, Kiel, Germany., Phoenix K; Department of Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Klumph KJ; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Robinson H; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Veyel D; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Muller A; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Noyvert B; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Bartholdy BA; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Steixner-Kumar AA; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Stutzki J; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Drichel D; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Omland S; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Sheehan R; Department of Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Hill J; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Bretschneider T; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Gottschling D; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Scheidig AJ; Department of Biology, Institute of Zoology-Structural Biology, Christian Albrechts University, Kiel, Germany., Clement B; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany., Giera M; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; The Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands., Ding Z; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Broadwater J; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Warren CR; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2024 Apr 12; Vol. 8 (5). Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024).

Reduction of Hydrogen Peroxide by Human Mitochondrial Amidoxime Reducing Component Enzymes.

Autor: Rixen S; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany., Indorf PM; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany., Kubitza C; Department of Structural Biology, Zoological Institute, Kiel University, 24118 Kiel, Germany., Struwe MA; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany.; Department of Structural Biology, Zoological Institute, Kiel University, 24118 Kiel, Germany., Klopp C; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany.; Department of Structural Biology, Zoological Institute, Kiel University, 24118 Kiel, Germany., Scheidig AJ; Department of Structural Biology, Zoological Institute, Kiel University, 24118 Kiel, Germany., Kunze T; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany., Clement B; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Kiel University, 24118 Kiel, Germany.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 31; Vol. 28 (17). Date of Electronic Publication: 2023 Aug 31.

The History of mARC.

Autor: Clement B; Pharmazeutisches Institut, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118 Kiel, Germany., Struwe MA; Pharmazeutisches Institut, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.; Zoologisches Institut-Strukturbiologie, Zentrum für Biochemie und Molekularbiologie, Christian-Albrechts-Universität zu Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Jun 12; Vol. 28 (12). Date of Electronic Publication: 2023 Jun 12.

Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.

Autor: Struwe MA; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia; Pharmazeutisches Institut, Christian-Albrechts-Universität Kiel, Kiel, Germany., Kalimuthu P; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Luo Z; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia., Zhong Q; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Ellis D; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Yang J; Department of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico, USA., Khadanand KC; Department of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico, USA., Harmer JR; Centre for Advanced Imaging, The University of Queensland, Brisbane, Qld, Australia., Kirk ML; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia., McEwan AG; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Clement B; Pharmazeutisches Institut, Christian-Albrechts-Universität Kiel, Kiel, Germany., Bernhardt PV; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Kobe B; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia., Kappler U; Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia. Electronic address: u.kappler@uq.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100672. Date of Electronic Publication: 2021 Apr 20.