Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

Autor: Li M; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Oliveira Passos D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Shan Z; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Smith SJ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Sun Q; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Biswas A; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Choudhuri I; Center for Biophysics and Computational Biology, and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA., Strutzenberg TS; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Haldane A; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Deng N; Department of Chemistry and Physical Sciences, Pace University, New York, NY, 10038, USA., Li Z; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Zhao XZ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Briganti L; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Kvaratskhelia M; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Burke TR Jr; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Levy RM; Center for Biophysics and Computational Biology and Department of Physics, Temple University, Philadelphia, PA 19122, USA., Hughes SH; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Craigie R; National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Lyumkis D; The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science advances [Sci Adv] 2023 Jul 21; Vol. 9 (29), pp. eadg5953. Date of Electronic Publication: 2023 Jul 21.

Discovery of an NAD ⁺ analogue with enhanced specificity for PARP1.

Autor: Zhang XN; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Lam AT; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Cheng Q; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Courouble VV; Department of Molecular Medicine, The Scripps Research Institute Jupiter FL 33458 USA., Strutzenberg TS; Department of Molecular Medicine, The Scripps Research Institute Jupiter FL 33458 USA., Li J; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Wang Y; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Pei H; Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA., Stiles BL; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu., Louie SG; Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA., Griffin PR; Department of Molecular Medicine, The Scripps Research Institute Jupiter FL 33458 USA., Zhang Y; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles CA 90089 USA yongz@usc.edu.; Department of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California Los Angeles CA 90089 USA.; Norris Comprehensive Cancer Center, University of Southern California Los Angeles CA 90089 USA.; Research Center for Liver Diseases, University of Southern California Los Angeles CA 90089 USA.

Publikováno v: Chemical science [Chem Sci] 2022 Jan 27; Vol. 13 (7), pp. 1982-1991. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2022).

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

Autor: Strutzenberg TS; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Zhu Y; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Novick SJ; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Garcia-Ordonez RD; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Doebelin C; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., He Y; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Chang MR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Kamenecka TM; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Edwards DP; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: pgriffin@scripps.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2021 Nov 05; Vol. 433 (22), pp. 167258. Date of Electronic Publication: 2021 Sep 20.

Structure of an AMPK complex in an inactive, ATP-bound state.

Autor: Yan Y; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Mukherjee S; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Harikumar KG; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, USA., Strutzenberg TS; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA., Zhou XE; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Suino-Powell K; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Xu TH; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.; Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Sheldon RD; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Lamp J; Integrated Mass Spectrometry Unit, Department of Translational Neuroscience, Michigan State University College of Human Medicine, Grand Rapids Research Center, Grand Rapids, MI 49503, USA., Brunzelle JS; Life Sciences Collaborative Access Team, Northwestern University Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA., Radziwon K; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Ellis A; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Novick SJ; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA., Vega IE; Integrated Mass Spectrometry Unit, Department of Translational Neuroscience, Michigan State University College of Human Medicine, Grand Rapids Research Center, Grand Rapids, MI 49503, USA., Jones RG; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Miller LJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, USA., Xu HE; Center for Structure and Function of Drug Targets, The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China., Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA., Kossiakoff AA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.; Institute of Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA., Melcher K; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA. karsten.melcher@vai.org.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Jul 23; Vol. 373 (6553), pp. 413-419.

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ.

Autor: Mosure SA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL 33458, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA., Strutzenberg TS; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL 33458, USA.; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA., Shang J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA., Munoz-Tello P; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA., Solt LA; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA., Griffin PR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA., Kojetin DJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. dkojetin@scripps.edu.; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.

Publikováno v: Science advances [Sci Adv] 2021 Jan 27; Vol. 7 (5). Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).