Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Autor: Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.

Publikováno v: Science, 2014 Mar . 343(6176), 1260-1263.

Externí odkaz: http://www.jstor.org/stable/24743420

Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency

Autor: Strumane, Kristin, Song, Ji-Ying, Baas, Inge, Collard, John G.

Publikováno v: In Leukemia Research 2008 32(1):113-120

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Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

Autor: De Paepe Anne, Van Roy Frans, Menten Björn, Strumane Kristin, Pattyn Filip, Berx Geert, De Preter Katleen, Speleman Frank, Vandesompele Jo

Publikováno v: BMC Genomics, Vol 5, Iss 1, p 11 (2004)

Abstract Background Activation of proto-oncogenes by DNA amplification is an important mechanism in the development and maintenance of cancer cells. Until recently, identification of the targeted genes relied on labour intensive and time consuming po

Externí odkaz: https://doaj.org/article/a324ac4e9e434b5db4412aabdc20a519

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Autor: de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I, Sub Biomol.Mass Spectrometry & Proteom., Sub Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: PloS Biology [E], 14(1). Public Library of Science
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
PLoS Biology
de Jong, R N, Beurskens, F J, Verploegen, S, Strumane, K, van Kampen, M D, Voorhorst, M, Horstman, W, Engelberts, P J, Oostindie, S C, Wang, H-G, Heck, A J R, Schuurman, J & Parren, P W H I 2016, ' A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface ', PLoS Biology, vol. 14, no. 1, e1002344, pp. e1002344 . https://doi.org/10.1371/journal.pbio.1002344

IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20b4bdc5f5cb3b10d2b50e70c8b89da
https://dspace.library.uu.nl/handle/1874/325541