Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Structure-based pharmacophore"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract In the realm of epigenetic regulation, Protein arginine deiminase 2 (PAD2) stands out as a therapeutic target due to its significant role in neurological disorders, rheumatoid arthritis (RA), multiple sclerosis (MS), and various cancers. To
Externí odkaz:
https://doaj.org/article/f280e9729b4f41e7a5e07b0123b1a020
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractColorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing to the complex mechanism of tumorigenesis, simultaneous inhibition of multiple targets is an important anticancer strategy. Recent studies have demonstrated
Externí odkaz:
https://doaj.org/article/c0259a46e9354907be2849c602177314
Autor:
Shafiul Haque, Darin Mansor Mathkor, Ayman K. Johargy, Hani Faidah, Ahmad O. Babalghith, Sumyya H. Hariri, Naif A. Jalal, Faraz Ahmad, Farkad Bantun
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 8, Pp 103290- (2024)
Objectives: Bacterial infections expressing New Delhi metallo-lactamase-1 (NDM-1) pose an escalating global threat to healthcare systems. NDM-1 is an enzyme that renders β-lactam antibiotics ineffective, leading to resistance against numerous antibi
Externí odkaz:
https://doaj.org/article/b132bc8f18094889b548dd352f08b3da
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Breast cancer, a leading cause of female mortality, is closely linked to mutations in estrogen receptor beta (ESR2), particularly in the ligand‐binding domain, which contributed to altered signaling pathways and uncontrolled cel
Externí odkaz:
https://doaj.org/article/ce55b163e9354b79b8b0270fc9073fe8
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Flavin monoamine oxidase gene encodes a protein (MAOB) that forms a part of the flavin monoamine oxidase family in the outer membrane of mitochondria. It plays a role in the tissue metabolism of neuroactive and vasoactive amines a
Externí odkaz:
https://doaj.org/article/642ae7de2fdc47c5929e1a3929f122ef
Autor:
Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed, Sahar M. Abou-Seri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 563-572 (2022)
On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly, a 3D pharmacoph
Externí odkaz:
https://doaj.org/article/dfc6cfd0c7e74656b4564f0943aef227
Akademický článek
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Akademický článek
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Autor:
Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula, Yogish Kumar Honnavalli
Publikováno v:
Molecules, Vol 28, Iss 6, p 2490 (2023)
CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resist
Externí odkaz:
https://doaj.org/article/c83ed7dc846a4d0c8ba4c14dbc0e36cb
Akademický článek
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