Zobrazeno 1 - 10
of 3 917
pro vyhledávání: '"Structure-based drug design"'
Autor:
Richa Arya, Smita Jain, Sarvesh Paliwal, Kirtika Madan, Swapnil Sharma, Achal Mishra, Prashant Tiwari, Sunil Kumar Kadiri
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 9, Pp 369-381 (2024)
Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta (Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β-secretase, also known as β-site amyloid precursor protein cleaving
Externí odkaz:
https://doaj.org/article/951eb488d02145528b4cd5f5f3dabbf5
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 3919-3945 (2024)
This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development. ADAR proteins can correct or diversify genetic information, underscoring th
Externí odkaz:
https://doaj.org/article/cf70b680ab7646289db8e179217965fc
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
The filamentous fungus Magnaporthe oryzae is widely recognized as a notorious plant pathogen responsible for causing rice blasts. With rapid advancements in molecular biology technologies, numerous regulatory mechanisms have been thoroughly investiga
Externí odkaz:
https://doaj.org/article/f145154867084663a672bc9ba9c51b69
Autor:
Anuradha Singh
Publikováno v:
Artificial Intelligence Chemistry, Vol 2, Iss 2, Pp 100071- (2024)
Traditional drug discovery struggles to keep pace with the ever-evolving threat of infectious diseases. New viruses and antibiotic-resistant bacteria, all demand rapid solutions. Artificial Intelligence (AI) offers a promising path forward through ac
Externí odkaz:
https://doaj.org/article/15e1da79583646e6bd68280ed588f9ba
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Breast cancer, a leading cause of female mortality, is closely linked to mutations in estrogen receptor beta (ESR2), particularly in the ligand‐binding domain, which contributed to altered signaling pathways and uncontrolled cel
Externí odkaz:
https://doaj.org/article/ce55b163e9354b79b8b0270fc9073fe8
Autor:
Saudatu Chinade Jáafaru, Adamu Uzairu, Muhammed Sani Sallau, George Iloegbulam Ndukwe, Muhammad Tukur Ibrahim, Kamal Tabti, Pallavi Kandpal, Vimal Kumar
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02169- (2024)
Schistosomiasis is a chronic parasitic disease with significant public health challenges due to the limited number of treatment options and increasing levels of drug resistance against the only available drug, Praziquantel (PZQ). Consequently, there
Externí odkaz:
https://doaj.org/article/eff6acc3d3fe4753a817d37b6eaf62bd
Autor:
Hathaichanok Chuntakaruk, Kowit Hengphasatporn, Yasuteru Shigeta, Chanat Aonbangkhen, Vannajan Sanghiran Lee, Tanatorn Khotavivattana, Thanyada Rungrotmongkol, Supot Hannongbua
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The prevalence of HIV-1 infection continues to pose a significant global public health issue, highlighting the need for antiretroviral drugs that target viral proteins to reduce viral replication. One such target is HIV-1 protease (PR), resp
Externí odkaz:
https://doaj.org/article/eaf267eba1394fc79446799e308a43b5
Autor:
Fetian MH, Al-Balas QA
Publikováno v:
Advances and Applications in Bioinformatics and Chemistry, Vol Volume 17, Pp 21-32 (2024)
Mohammad H Fetian, Qosay A Al-Balas Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Qosay A Al-Balas, Department of Medicinal Chemistry & Pharmacognos
Externí odkaz:
https://doaj.org/article/d35a2e39e2884ab68b5d62cba857f44c
Autor:
Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, Xuewu Liang, Xia Peng, Jiyuan Li, Yangrong Zhao, Chunpu Li, Danyi Wang, Yazhou Li, Dong Zhang, Dan Zhang, Meiyu Geng, Hong Liu, Jing Ai, Yu Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4918-4933 (2023)
As a novel and promising antitumor target, AXL plays an important role in tumor growth, metastasis, immunosuppression and drug resistance of various malignancies, which has attracted extensive research interest in recent years. In this study, by empl
Externí odkaz:
https://doaj.org/article/d516c2f765514631b7bf774badc1f3ce
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100130- (2024)
The type-II collagenase, also known as matrix metalloproteinase-8 (MMP-8) plays a vital role in a variety of physiological illnesses namely cardiovascular, musculoskeletal, renal, digestive, and respiratory ailments including cancer. However, numerou
Externí odkaz:
https://doaj.org/article/57a2024abeb7440588f688b9fd08eb6e