Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults.

Autor: King DR; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Demirtas M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Tarasov M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Struckman HL; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Meng X; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Nassal D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Moise N; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Miller A; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Min D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Soltisz AM; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Anne MNK; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Alves Dias PA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Akademika Heyrovského Hradec Králové, Czech Republic., Wagnon JL; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Weinberg SH; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Hund TJ; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; Department of Internal Medicine, Division of Cardiovascular Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Veeraraghavan R; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Radwański PB; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA. Electronic address: radwanski.2@osu.edu.

Publikováno v: JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2024 May; Vol. 10 (5), pp. 829-842. Date of Electronic Publication: 2024 Feb 28.

Unraveling Impacts of Chamber-Specific Differences in Intercalated Disc Ultrastructure and Molecular Organization on Cardiac Conduction.

Autor: Struckman HL; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Moise N; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., King DR; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Soltisz A; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Buxton A; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA., Dunlap I; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Chen Z; Krannert Cardiovascular Research Center, Department of Medicine, Indiana University, Indianapolis, Indiana, USA., Radwański PB; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Outcomes and Translational Sciences, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Weinberg SH; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Veeraraghavan R; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address: veeraraghavan.12@osu.edu.

Publikováno v: JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2023 Dec; Vol. 9 (12), pp. 2425-2443. Date of Electronic Publication: 2023 Jul 26.

NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.

Autor: Tarasov M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Struckman HL; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Biomedical Engineering, College of Engineering., Olgar Y; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Miller A; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Demirtas M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Bogdanov V; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Terentyeva R; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Soltisz AM; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Biomedical Engineering, College of Engineering., Meng X; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Min D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy., Sakuta G; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Dunlap I; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Biomedical Engineering, College of Engineering., Duran AD; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA., Foster MP; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA., Davis JP; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Terentyev D; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Györke S; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine., Veeraraghavan R; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Department of Biomedical Engineering, College of Engineering., Radwański PB; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.; Division of Outcomes and Translational Sciences, College of Pharmacy.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Apr 03; Vol. 133 (7). Date of Electronic Publication: 2023 Apr 03.

Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention.

Autor: Ortega-Pineda L; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Sunyecz A; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Salazar-Puerta AI; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Rincon-Benavides MA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Alzate-Correa D; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Anaparthi AL; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Guilfoyle E; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Mezache L; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Struckman HL; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Duarte-Sanmiguel S; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Deng B; Center for Electron Microscopy and Analysis (CEMAS), The Ohio State University, Columbus, OH, 43212, USA., McComb DW; Center for Electron Microscopy and Analysis (CEMAS), The Ohio State University, Columbus, OH, 43212, USA.; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH, 43210, USA., Dodd DJ; Biomedical Science Graduate Program, The Ohio State University, Columbus, OH, 43210, USA., Lawrence WR; Biomedical Science Graduate Program, The Ohio State University, Columbus, OH, 43210, USA., Moore J; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Zhang J; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA., Reátegui E; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA., Veeraraghavan R; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA., Nelson MT; Air Force Research Laboratory, 711th Human Performance Wing, Wright-Patterson Air Force Base, OH 45433, USA., Gallego-Perez D; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.; Department of Surgery, The Ohio State University, Columbus, Ohio, 43210, USA., Higuita-Castro N; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.; Department of Surgery, The Ohio State University, Columbus, Ohio, 43210, USA.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2022 Mar; Vol. 11 (5), pp. e2100805. Date of Electronic Publication: 2022 Jan 21.

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14^Δ/+ mice hearts.

Autor: Foo, Brian^1,2 (AUTHOR) brian.foo@med.uni-goettingen.de, Amedei, Hugo³ (AUTHOR), Kaur, Surmeet³ (AUTHOR), Jaawan, Samir^1,2 (AUTHOR), Boshnakovska, Angela⁴ (AUTHOR), Gall, Tanja⁴ (AUTHOR), de Boer, Rudolf A.^5,6 (AUTHOR), Silljé, Herman H. W.⁵ (AUTHOR), Urlaub, Henning^2,3,7 (AUTHOR), Rehling, Peter⁴ (AUTHOR), Lenz, Christof^2,3,7 (AUTHOR) christof.lenz@med.uni-goettingen.de, Lehnart, Stephan E.^1,2 (AUTHOR) brian.foo@med.uni-goettingen.de

Publikováno v: PLoS ONE. 10/24/2024, Vol. 19 Issue 10, p1-45. 45p.