Negative Feedback Regulation of TGF- Signaling by the SnoN Oncoprotein

Autor: Stroschein, S. L.

Smad proteins mediate transforming growth factor–β (TGF-β) signaling to regulate cell growth and differentiation. The SnoN oncoprotein was found to interact with Smad2 and Smad4 and to repress their abilities to activate transcription through rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2659::ef877ef15d11a976d5b62b1baf859872
https://zenodo.org/record/1231169

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.

Autor: Luo, K, Stroschein, S L, Wang, W, Chen, D, Martens, E, Zhou, S, Zhou, Q

Publikováno v: Genes & Development; September 1999, Vol. 13 Issue: 17 p2196-2206, 11p

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

Autor: Bonni S; Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada., Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL

Publikováno v: Nature cell biology [Nat Cell Biol] 2001 Jun; Vol. 3 (6), pp. 587-95.

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.

Autor: Stroschein SL; Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA., Wang W, Zhou S, Zhou Q, Luo K

Publikováno v: Science (New York, N.Y.) [Science] 1999 Oct 22; Vol. 286 (5440), pp. 771-4.