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Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.

Autor: Raina K; co-corresponding authors.; Halda Therapeutics OpCo Inc, New Haven CT USA., Forbes CD; Halda Therapeutics OpCo Inc, New Haven CT USA., Stronk R; Halda Therapeutics OpCo Inc, New Haven CT USA., Rappi JP Jr; Halda Therapeutics OpCo Inc, New Haven CT USA., Eastman KJ; Halda Therapeutics OpCo Inc, New Haven CT USA., Gerritz SW; Halda Therapeutics OpCo Inc, New Haven CT USA., Yu X; Halda Therapeutics OpCo Inc, New Haven CT USA., Li H; Halda Therapeutics OpCo Inc, New Haven CT USA., Bhardwaj A; Halda Therapeutics OpCo Inc, New Haven CT USA., Forgione M; Halda Therapeutics OpCo Inc, New Haven CT USA., Hundt A; Halda Therapeutics OpCo Inc, New Haven CT USA., King MP; Halda Therapeutics OpCo Inc, New Haven CT USA., Posner ZM; Halda Therapeutics OpCo Inc, New Haven CT USA., Denny A; Halda Therapeutics OpCo Inc, New Haven CT USA., McGovern A; Halda Therapeutics OpCo Inc, New Haven CT USA., Puleo DE; Halda Therapeutics OpCo Inc, New Haven CT USA., Garvin E; Halda Therapeutics OpCo Inc, New Haven CT USA., Chenard R; Halda Therapeutics OpCo Inc, New Haven CT USA., Zaware N; Halda Therapeutics OpCo Inc, New Haven CT USA., Mousseau JJ; Halda Therapeutics OpCo Inc, New Haven CT USA., Macaluso J; Halda Therapeutics OpCo Inc, New Haven CT USA., Martin M; Halda Therapeutics OpCo Inc, New Haven CT USA., Bassoli K; Halda Therapeutics OpCo Inc, New Haven CT USA., Jones K; Halda Therapeutics OpCo Inc, New Haven CT USA., Garcia M; Halda Therapeutics OpCo Inc, New Haven CT USA., Howard K; Halda Therapeutics OpCo Inc, New Haven CT USA., Smith LM; Halda Therapeutics OpCo Inc, New Haven CT USA., Chen JM; Halda Therapeutics OpCo Inc, New Haven CT USA., De Leon CA; Department of Molecular, Cellular, & Developmental Biology, Yale University New Haven CT USA., Hines J; Department of Molecular, Cellular, & Developmental Biology, Yale University New Haven CT USA., Kayser-Bricker KJ; Halda Therapeutics OpCo Inc, New Haven CT USA., Crews CM; co-corresponding authors.; Department of Molecular, Cellular, & Developmental Biology, Yale University New Haven CT USA.; Department of Pharmacology, Yale University New Haven CT USA.; Department of Chemistry, Yale University New Haven CT USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 02. Date of Electronic Publication: 2023 Jan 02.