Výsledky vyhledávání - "Stromal Cells/drug effects"

Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment

Autor: Cheng, H.S., Lee, JXT, Wahli, W., Tan, N.S.

Publikováno v: Molecular cancer, vol. 18, no. 1, pp. 51

The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::6fb2ecdd606bf63382af24798335ac80
https://serval.unil.ch/resource/serval:BIB_D37E23728556.P001/REF.pdf

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Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12

Autor: Akcora, Büsra Öztürk, Storm, Gert, Bansal, Ruchi, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease, 1864(3), 804-818. Elsevier
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(3), 804. Elsevier

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic morphological transformation into proliferative, contractile and ECM-producing myofibroblasts. In this study, we investigated the implication of canonical Wn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49c3c4bd0070f8e2a85578d91b05384
https://research.utwente.nl/en/publications/fdbc859d-eeb0-48f4-8123-96b424c00956

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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Autor: Ariel Ruiz i Altaba

Publikováno v: Cancer Cell, Vol. 14, No 4 (2008) pp. 281-3

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4c961c862d504fd20dffe0f61198a6
https://pubmed.ncbi.nlm.nih.gov/18835029

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Tumour necrosis factor-alpha up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-kappaB

Autor: M Morin, W-G Cao, Thierry Roger, Valérie Sengers, Christine N. Metz, R Maheux, Ali Akoum

Publikováno v: Human Reproduction (oxford, England), vol. 21, no. 2, pp. 421-428

BACKGROUND A series of controlled changes including proliferation, secretion and menstrual shedding occur in the human endometrium during every normal menstrual cycle. Macrophage migration inhibitory factor (MIF), a multifunctional cytokine with nume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa910c028736facd64f206bee2d1e332
https://serval.unil.ch/resource/serval:BIB_138741830708.P001/REF.pdf

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