Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Strohmeyer Timothy W"'
Publikováno v:
Synthetic Communications. 30:1233-1238
A reproducible synthesis of 2,5-anhydro-1-amino-1,4-dideoxy-3-thio-D-threo-pentitol hydrochloride (2b) via the Staudinger reaction with triethyl phosphite was developed. An unexpected ethyl migration from an oxygen to the nitrogen of iminophosphorane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::866b53c3851b44611f9f15c260fbd822
https://doi.org/10.1080/00397910008087144
https://doi.org/10.1080/00397910008087144
Publikováno v:
Tetrahedron Letters. 38:5913-5916
The syntheses of novel tricyclic diazo carbapenem precursor 17 , and the deprotected carbapenems 2 and 3 are described. The construction of the tricyclic carbapenem was accomplished by an intramolecular nucleophilic substitution of the diazine sulfon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06235786dcfed449f0c672d1a0af324
https://doi.org/10.1016/s0040-4039(97)01321-x
https://doi.org/10.1016/s0040-4039(97)01321-x
Autor:
William J. Weiss, Youjun Yang, Stanley A. Lang, Testa Raymond T, Strohmeyer Timothy W, Li Zhong, Panayota Bitha, N V Jacobus, Niraja Bhachech, Lin Yang I, Karen Bush, Peter Petersen, Subas M. Sakya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1811-1816
Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were synthesized. Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b0ed81caee24aaf9f7d4e3e9eec6079
https://doi.org/10.1016/s0960-894x(97)00305-3
https://doi.org/10.1016/s0960-894x(97)00305-3
Autor:
William J. Weiss, Subas M. Sakya, Nilda V. Jacobus, Francis P. Tally, Karen Bush, Panayota Bitha, Lin Yang I, Stanley A. Lang, Strohmeyer Timothy W, Peter Petersen, Niraja Bhachech, Youjun Yang, Li Zhong, Testa Raymond T, Ving J. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1671-1676
A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only modera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e7cf0fda2095464b1f1974109e04d23
https://doi.org/10.1016/s0960-894x(97)00282-5
https://doi.org/10.1016/s0960-894x(97)00282-5
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1805-1810
Six disubstituted oxetane carbapenems were synthesized and their antibacterial profile compared with the lead amino methyl THF carbapenem as well as imipenem. The oxetane carbapenems had comparable or less activity against the Gram(−) bacteria and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0fba1e8c01fd6d670634a1b436acdf
https://doi.org/10.1016/s0960-894x(97)00280-1
https://doi.org/10.1016/s0960-894x(97)00280-1
Autor:
William V. Curran, K. Short, Y. Lin, Carl Bernard Ziegler, P. Fabio, Panayota Bitha, Strohmeyer Timothy W, Gregg Brian Feigelson
Publikováno v:
Tetrahedron. 50:12085-12096
The synthesis of 2-[(4-fluorophenylsulfonyl)methyl] carbapenem carboxylate 20 is described. The key step is a base mediated addition-elimination ring closure of a iodovinyl sulfone 12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce8b6668231088571c332d622526317
https://doi.org/10.1016/s0040-4020(01)89561-2
https://doi.org/10.1016/s0040-4020(01)89561-2
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c0909cbe73fa62ed9b3f57ca206c0b
https://doi.org/10.1002/chin.199119181
https://doi.org/10.1002/chin.199119181
Autor:
Panayota Bitha, Strohmeyer Timothy W, C. B. Jun. Ziegler, William V. Curran, Gregg Brian Feigelson, K. M. Short, Paul F. Fabio, Y. Lin
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7dd2ed9b8b799a76bf7b3a1f36a25d8
https://doi.org/10.1002/chin.199513288
https://doi.org/10.1002/chin.199513288
Publikováno v:
ChemInform. 28
The syntheses of novel tricyclic diazo carbapenem precursor 17 , and the deprotected carbapenems 2 and 3 are described. The construction of the tricyclic carbapenem was accomplished by an intramolecular nucleophilic substitution of the diazine sulfon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11cae1108912db851941376b23dfda98
https://doi.org/10.1002/chin.199747266
https://doi.org/10.1002/chin.199747266
Autor:
Zhong Li, William J. Weiss, Subas M. Sakya, F. P. Tally, Niraja Bhachech, Ving J. Lee, Karen Bush, Panayota Bitha, Peter Petersen, N. V. Jacobus, Strohmeyer Timothy W, S. A. Jun. Lang, Youjun Yang, Y. Lin, Testa Raymond T
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4c87ad7928b1cf1164636b3bcd18b8
https://doi.org/10.1002/chin.199746237
https://doi.org/10.1002/chin.199746237