Zobrazeno 1 - 10
of 2 221
pro vyhledávání: '"Stringham HM"'
Autor:
Varshney A; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Manickam N; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Orchard P; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Tovar A; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Zhang Z; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Feng F; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ventresca C; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Dept. of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Nishino K; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Rai V; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Jackson AU; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Tamsen T; Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA., Gao C; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Yang M; Department of Internal Medicine, Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, USA., Koues OI; Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA., Welch JD; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Williams LK; Department of Internal Medicine, Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, USA., Jenkinson C; South Texas Diabetes and Obesity Research Institute, School of Medicine, University of Texas, Rio Grande Valley, TX, USA., DeFronzo RA; Department of Medicine/Diabetes Division, University of Texas Health, San Antonio, TX, USA., Norton L; Department of Medicine/Diabetes Division, University of Texas Health, San Antonio, TX, USA., Saramies J; Savitaipale Health Center, South Karelia Central Hospital, Lappeenranta, Finland., Lakka TA; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Tuomilehto J; Dept. of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Dept. of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Mohlke KL; Dept. of Genetics, University of North Carolina, Chapel Hill, NC, USA., Kitzman JO; Dept. of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Koistinen HA; Dept. of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Liu J; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Scott LJ; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Parker SCJ; Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Dept. of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 15. Date of Electronic Publication: 2023 Dec 15.
Autor:
Brotman SM; Department of Genetics, The University of North Carolina, Chapel Hill, NC., Oravilahti A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Rosen JD; Department of Genetics, The University of North Carolina, Chapel Hill, NC., Alvarez M; Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA., Heinonen S; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., van der Kolk BW; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Perrin HJ; Department of Genetics, The University of North Carolina, Chapel Hill, NC., Vadlamudi S; Department of Genetics, The University of North Carolina, Chapel Hill, NC., Pylant C; Department of Epidemiology, The University of North Carolina, Chapel Hill, NC., Deochand S; Department of Epidemiology, The University of North Carolina, Chapel Hill, NC., Basta PV; Department of Epidemiology, The University of North Carolina, Chapel Hill, NC., Valone JM; Department of Genetics, The University of North Carolina, Chapel Hill, NC.; UNC Neuroscience Center, The University of North Carolina, Chapel Hill, NC., Narain MN; Department of Genetics, The University of North Carolina, Chapel Hill, NC.; Curriculum of Toxicology and Environmental Medicine, The University of North Carolina, Chapel Hill, NC., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Love MI; Department of Genetics, The University of North Carolina, Chapel Hill, NC.; Department of Biostatistics, The University of North Carolina, Chapel Hill, NC., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; HealthyWeightHub, Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA.; Institute for Precision Health, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Mohlke KL; Department of Genetics, The University of North Carolina, Chapel Hill, NC.
Publikováno v:
Diabetes [Diabetes] 2023 Nov 01; Vol. 72 (11), pp. 1707-1718.
Autor:
Brotman SM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., El-Sayed Moustafa JS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Guan L; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Broadaway KA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Welch R; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Currin KW; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Tomlinson M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Roberts AL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Oravilahti A; Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland., Silva LF; Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Yan T; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Raulerson CK; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Raza Y; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Yan X; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Parker SCJ; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Kuusisto J; Department of Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland., Pajukanta P; Department of Human Genetics and Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Love MI; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Laakso M; Institute of Clinical Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.; Department of Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 27. Date of Electronic Publication: 2023 Oct 27.
Autor:
Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; General Medicine Center, Saarland University Faculty of Medicine, Homburg, 66421, Germany., Ng NHJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Fernandez J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Fine RS; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Current address: Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA, 02210, USA., Wheeler E; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Wessel J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Departments of Epidemiology & Medicine, Schools of Public Health & Medicine, Indiana University, Indianapolis, IN, 46202, USA.; Diabetes Translational Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA., Kitajima H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Marenne G; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Sim X; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Chen S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden., Asimit JL; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Feng S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Strawbridge RJ; Mental Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, 171 76, Sweden., Kleinbrink EL; Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, 48201-1928, USA., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark., An P; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA., Appel EV; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Auvinen J; Center for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Bihlmeyer NA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Brody JA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Demirkan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Floyd JS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 75237, Sweden., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Järvelin MR; Center for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland., Jensen RA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Keinanen-Kiukaanniemi S; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; MRC and Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Li M; Division of Nephrology, Internal Medicine, School of Medicine, University of Utah, Salt Lake City, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.; Department of Medicine, Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Manning AK; Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Muka T; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Pistis G; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Prins B; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Rice KM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Sanna S; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, 9700 RB, The Netherlands., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Southam L; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Tragante V; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Yiorkas AM; Section of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.; Department of Life Sciences, Brunel University London, London, UB8 3PH, UK., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Highland HM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Human Genetics Center, The University of Texas School of Public Health; The University of Texas Graduate School of Biomedical Sciences at Houston;, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Medina-Gomez C; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Afaq S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK., Alhejily WA; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Asselbergs FW; Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA., Bots ML; Center for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark., Chen J; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB18RN, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Ebeling T; Oulu University Hospital, Oulu, 90220, Finland., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Imperial College NIHR Biomedical Research Centre, London, UK.; Health Data Research UK, Imperial College London, London, UK., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Franks PW; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK., Fritsche A; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hallmans G; Department of Biobank Research, Umeå University, Umeå, SE-901 87, Sweden., Harris TB; Icelandic Heart Association, Kopavogur, Iceland., Herzig KH; Institute of Biomedicine and Biocenter of Oulu, Faculty of Medicine, Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, 60-572, Poland., Hivert MF; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Jørgensen T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Faculty of Medicine, University of Aalborg, Aalborg, 9100, Denmark., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark.; National Institute of Public Health, Southern Denmark University, Odense, 5000, Denmark., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Kajantie E; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Karaleftheri M; Echinos Medical Centre, Echinos, Greece., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kinnunen L; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U Helsinki, Helsinki, FI-00290, Finland., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kovacs P; Integrated Research and Treatment (IFB) Center Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, 04103, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Lange LA; Department of Medicine, Division of Bioinformatics and Personalized Medicine, University of Colorado Denver, Denver, CO, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Leong A; Division of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA., Lindström J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Manning Fox JE; Alberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.; Department of Pharmacology, University of Alberta, Edmonton, T6G 2E1, Canada., Männistö S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Maruthur NM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA., Moilanen L; Kuopio University Hospital, Kuopio, 70210, Finland., Mulas A; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, 07100, Italy., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA.; Data Tecnica International LLC, Glen Echo, MD, 20812, USA., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Petersen ERB; Department of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark., Puolijoki H; South Ostobothnia Central Hospital, Seinajoki, 60220, Finland., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Redmond P; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.; Department of Biobank Research, Umeå University, Umeå, SE-901 87, Sweden., Roden M; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Biostatistics and Epidemiology, University of Pennsylvania, 19104, USA., Saltevo J; Central Finland Central Hospital, Jyvaskyla, 40620, Finland., Savonen K; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70029, Finland., Sebert S; Biocenter Oulu, University of Oulu, Oulu, Finland.; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland., Skaaby T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Stokholm J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Strauch K; Institute of Genetic Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tai ES; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany., Tsafantakis E; Anogia Medical Centre, Anogia, Greece., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland., Vääräsmäki M; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Welfare, Children, Adolescents and Families Unit, National Institute for Health and Welfare, Oulu, Finland., Vaartjes I; Center for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands., Zoledziewska M; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy., Abecasis G; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Balkau B; INSERM U1018, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Blakemore AI; Section of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.; Department of Life Sciences, Brunel University London, London, UB8 3PH, UK., Blüher M; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany., Boerwinkle E; The Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, 77030, USA., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Chambers JC; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard School of Medicine, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA., Cucca F; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, 07100, Italy., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Ferrannini E; CNR Institute of Clinical Physiology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Grallert H; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, 5000, Denmark., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hirschhorn JN; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, 02115, USA., Ikram A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, 94305, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK., Kaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB1 8RN, UK., Kiess W; Pediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany., Kooner JS; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Körner A; Pediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany., Lakka T; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70029, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, 70211, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Lind L; Department of Medical Sciences, Molecular Epidemiology; EpiHealth, Uppsala University, Uppsala, 75185, Sweden., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7BN, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Lipovich L; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, 48201-1928, USA.; Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Liu Y; Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, 27157, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA., MacDonald PE; Alberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.; Department of Pharmacology, University of Alberta, Edmonton, T6G 2E1, Canada., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Murray A; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill Health Campus, Aberdeen, AB25 2ZD, UK., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.; Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Porteous D; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Epidemiology, Health Systems and Population Health, University of Washington, Seattle, Seattle, WA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard School of Medicine, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Rolandsson O; Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå University, Umeå, SE-901 85, Sweden., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany., Sladek R; Department of Medicine, McGill University, Montreal, Quebec, H4A 3J1, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada., Smith BH; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Walker M; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, NE2 4HH, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Florez JC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK.; Current address: Genentech, South San Francisco, CA, 94080, USA., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Current address: Genentech, South San Francisco, CA, 94080, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK.; Division of Endocrinology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Barroso I; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Exeter Centre of Excellence in Diabetes (EXCEED), University of Exeter Medical School, Exeter, UK.
Publikováno v:
Wellcome open research [Wellcome Open Res] 2023 Oct 20; Vol. 8, pp. 483. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).
Autor:
Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ulrich A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Zudina L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., González KSG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Faggian A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Maina JG; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Todorov PV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sharapov S; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., David A; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK., Marullo L; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rujan RM; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gao Η; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Εvangelou Ε; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Benyamin B; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Willems SM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Meisinger C; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Corrêa IR Jr; New England Biolabs, Ipswich, MA, USA., Farber-Eger E; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schmidberger J; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hveem K; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Shmeliov A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Haenle M; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore., Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK., Salem V; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Florez JC; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Montgomery G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Tzoulaki I; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Brittain EL; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Groop L; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Deganutti G; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Demirkan A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Reynolds CA; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Aulchenko YS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk., Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
Publikováno v:
Nature genetics [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. Date of Electronic Publication: 2023 Sep 07.
Autor:
Yin X, Li J, Bose D, Okamoto J, Kwon A, Jackson AU, Silva LF, Oravilahti A, Stringham HM, Ripatti S, Daly M, Palotie A, Scott LJ, Burant CF, Fauman EB, Wen X, Boehnke M, Laakso M, Morrison J
Publikováno v:
MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jun 29. Date of Electronic Publication: 2023 Jun 29.
Autor:
Erzurumluoglu, AM, Liu, M, Jackson, VE, Barnes, DR, Datta, G, Melbourne, CA, Young, R, Batini, C, Surendran, P, Jiang, T, Adnan, SD, Afaq, S, Agrawal, A, Altmaier, E, Antoniou, AC, Asselbergs, FW, Baumbach, C, Beirut, L, Bertelsen, S, Boehnke, M, Bots, ML, Brazel, DM, Chambers, JC, Chang-Claude, J, Chen, C, Corley, J, Chou, Y-L, David, SP, de Boer, RA, de Leeuw, CA, Dennis, JG, Dominiczak, AF, Dunning, AM, Easton, DF, Eaton, C, Elliott, P, Evangelou, E, Faul, JD, Foroud, T, Goate, A, Gong, J, Grabe, HJ, Haessler, J, Haiman, C, Hallmans, G, Hammerschlag, AR, Harris, SE, Hattersley, A, Heath, A, Hsu, C, Iacono, WG, Kanoni, S, Kapoor, M, Kaprio, J, Kardia, SL, Karpe, F, Kontto, J, Kooner, JS, Kooperberg, C, Kuulasmaa, K, Laakso, M, Lai, D, Langenberg, C, Le, N, Lettre, G, Loukola, A, Luan, J, Madden, PAF, Mangino, M, Marioni, RE, Marouli, E, Marten, J, Martin, NG, McGue, M, Michailidou, K, Mihailov, E, Moayyeri, A, Moitry, M, Müller-Nurasyid, M, Naheed, A, Nauck, M, Neville, MJ, Nielsen, SF, North, K, Perola, M, Pharoah, PDP, Pistis, G, Polderman, TJ, Posthuma, D, Poulter, N, Qaiser, B, Rasheed, A, Reiner, A, Renström, F, Rice, J, Rohde, R, Rolandsson, O, Samani, NJ, Samuel, M, Schlessinger, D, Scholte, SH, Scott, RA, Sever, P, Shao, Y, Shrine, N, Smith, JA, Starr, JM, Stirrups, K, Stram, D, Stringham, HM, Tachmazidou, I, Tardif, J-C, Thompson, DJ, Tindle, HA, Tragante, V, Trompet, S, Turcot, V, Tyrrell, J, Vaartjes, I, van der Leij, AR, van der Meer, P, Varga, TV, Verweij, N, Völzke, H, Wareham, NJ, Warren, HR, Weir, DR, Weiss, S, Wetherill, L, Yaghootkar, H, Yavas, E, Jiang, Y, Chen, F, Zhan, X, Zhang, W, Zhao, W, Zhou, K, Amouyel, P, Blankenberg, S, Caulfield, MJ, Chowdhury, R, Cucca, F, Deary, IJ, Deloukas, P, Di Angelantonio, E, Ferrario, M, Ferrières, J, Franks, PW, Frayling, TM, Frossard, P, Hall, IP, Hayward, C, Jansson, J-H, Jukema, JW, Kee, F, Männistö, S, Metspalu, A, Munroe, PB, Nordestgaard, BG, Palmer, CNA, Salomaa, V, Sattar, N, Spector, T, Strachan, DP, Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ Consortium, van der Harst, P, Zeggini, E, Saleheen, D, Butterworth, AS, Wain, LV, Abecasis, GR, Danesh, J, Tobin, MD, Vrieze, S, Liu, DJ, Howson, JMM
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2dcc9e0cb996255a99cde2618200dfa2
https://openaccess.sgul.ac.uk/id/eprint/110459/20/s41380-018-0313-0.pdf
https://openaccess.sgul.ac.uk/id/eprint/110459/20/s41380-018-0313-0.pdf
Autor:
Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhu X; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Clarke SL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Vedantam S; Boston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO, 63108, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Zajac GJM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Hilliard AT; VA Palo Alto Health Care Systems, Palo Alto, CA, USA., Wang Z; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Thorleifsson G; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Helgadottir A; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Gudbjartsson DF; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland., Holm H; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik, 101, Iceland., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Takayama J; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Martin HC; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Haessler J; Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, EH16 4UX, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Rasheed A; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Sengupta D; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Brown MR; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Gao Z; Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Mitchell RE; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bjerregaard AA; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; Aragon Institute of Engineering Research, University of Zaragoza and Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales Y Nanomedicina, Spain., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Mauro P; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy., Matteo F; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.; Dipartimento Di Scienze Biomediche, Università Degli Studi Di Sassari, Sardinia, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Dept of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Poveda A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Kurbasic A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Lamina C; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Forer L; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research LLC, Wayne, PA, 19087, USA., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Daw E; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Vazquez-Moreno M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK., Tsao NL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Lo KS; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Zilhao NR; Icelandic Heart Association, 201, Kopavogur, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim GmbH, 68163, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Yang J; School of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, Surrey, UK., Leonard HL; Laboratory of Neurogenetics, National Institute On Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Frank M; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain.; Hematology Department, Hospital Universitario Virgen de Las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Hutri-Kähönen N; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Huerta-Chagoya A; CONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico City, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Lyssenko V; Lund University Diabetes Center, Lund University, Malmö, Sweden.; Center for Diabetes Research, University of Bergen, Bergen, Norway., Nongmaithem SS; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Bayyana S; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Stringham HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea.; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Duke-NUS Medical School, Health Services and Systems Research, Singapore, 169857, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, 80045, USA., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Theusch E; Department of Pediatrics, University of California San Francisco, Oakland, CA, 94609, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, 01003, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, Dong Cheng District, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Banas B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany., Nardone GG; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Clinical Epidemiology, Institute of Health Informatics, University College London, London, UK., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Massachusetts General Hospital Cancer Center, Charlestown, MA, 02129, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.; Department of Engineering Technology, University of Houston-Sugarland, Houston, TX, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Bentley AR; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Doumatey AP; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Adeyemo AA; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Lee JY; Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, Korea., Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark., Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Québec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, 33521, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD, 4102, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Hidalgo B; Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Tang H; Department of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA, 94305, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, 43210, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Center for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia., Kovacs P; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, 17676, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 5650871, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 5650871, Japan., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, Korea., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Dept of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, 3584CG, Utrecht, the Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW, 2145, Australia., Hewitt AW; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Liverpool St, Hobart, TAS, 7000, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, 3002, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Québec, Canada.; Centre Nutrition, Santé Et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Québec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Tönjes A; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Mori TA; Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Lee H; Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15232, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Polasek O; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Physical Activity and Health, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Bandinelli S; Local Health Unit Toscana Centro, Florence, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kato N; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada Di Fiume 447, 34149, Trieste, Italy., Böger CA; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Jung B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center, New York, NY, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Mamakou V; Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27, Athens, Greece.; Dromokaiteio Psychiatric Hospital, 124 61, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, 68167, Mannheim, Germany.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland.; Privatpraxis Prof Jonas Und Dr Panda-Jonas, Heidelberg, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA., Tusié-Luna T; Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, 6000, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, 6000, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Krauss RM; Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Penninx B; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, Korea., Attia J; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, USA., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84132, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, P.O.Box 340, 00029, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290, Helsinki, Finland., Chandak GR; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.; JSS Academy of Higher Education and Research, Mysuru, India., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA., Costanzo MC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jang D; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burtt NP; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Villalpando CG; InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Tai E; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 119228, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Yokota M; Kurume University School of Medicine, Kurume, 830-0011, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Simonsick E; Intramural Research Program, National Institute On Aging, 3001 S. Hanover St., Baltimore, MD, 21225, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, 100730, China.; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Gudnason V; Icelandic Heart Association, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Lettre G; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Hart LM'; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, 1081HV, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam Cardiovascular Sciences, Amsterdam, 1081HV, the Netherlands., Elders PJM; Department of General Practice, Amsterdam UMC, Amsterdam, 1081HV, the Netherlands.; Amsterdam Public Health Research Institute, Health Behaviours and Chronic Diseases, Amsterdam, 1081HV, the Netherlands., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, 19104, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Rotimi CN; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Grant SFA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., de Graaf J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany., Kronenberg F; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Gu D; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany., Schunkert H; Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany., Franks PW; Lund University Diabetes Center, Lund University, Malmö, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Khera AV; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Verve Therapeutics, Cambridge, MA, USA., Männikkö M; Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter of Oulu, University of Oulu, Oulu, Finland., Kutalik Z; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Francesco C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy.; University of Sassari, Sassari, Italy., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., van Dijk KW; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sever P; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Poulter N; School of Public Health, Imperial College London, London, W12 7RH, UK., Chuang LM; Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Karpe F; OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Neville MJ; OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Li H; Data Science, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Hattersley AT; Medical School, University of Exeter, University of Exeter, Exeter, EX2 5DW, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Willemsen AHM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Cupples L; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin, Berlin, Germany., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts Der Isar, TUM School of Medicine, Munich, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, 94305, USA., Abecasis G; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, UK., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; School of Public Health, Imperial College London, London, W12 7RH, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Hazelhurst S; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Daviglus M; Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Martin NG; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia., Whitfield JB; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia., Abbas S; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.; Faisalabad Institute of Cardiology, Faislabad, Pakistan., Saleheen D; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Big Data Institute, University of Oxford, Oxford, OX3 7LF, UK., Holmes MV; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, UK., Black C; Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK., Baras A; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Justice AE; Department of Population Health Sciences, Geisinger Health, Danville, PA, 17822, USA., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Kooperberg C; Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA., Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trembath RC; School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Jarvik GP; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Washington, USA., Namjou B; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA., Hayes MG; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.; Department of Anthropology, Northwestern University, Evanston, IL, 60208, USA., Ritchie MD; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, 7600, Levanger, Norway.; Department of Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, 7600, Levanger, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Kubo M; RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Thorsteinsdottir U; deCODE Genetics/Amgen, Inc. 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Sturlugata 8, Reykjavik, 102, Iceland.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Chen Y; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Ho YL; VA Boston Healthcare System, Boston, MA, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; University of Massachusetts, Boston, MA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Tsao PS; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Corporal Michael J. 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Publikováno v:
Genome biology [Genome Biol] 2022 Dec 27; Vol. 23 (1), pp. 268. Date of Electronic Publication: 2022 Dec 27.
Autor:
Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Bose D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Kwon A; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Hanks SC; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Welch R; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Oravilahti A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA; Institute for Biomedicine, Eurac Research, Bolzano 39100, Italy., Service SK; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA., Erdos MR; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Bonnycastle LL; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland; Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio 70210, Finland., Stitziel NO; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA., Hall IM; Center for Genomic Health, Department of Genetics, Yale University, New Haven, CT 06510, USA., Morrison J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Ripatti S; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki 00290, Finland; Department of Public Health, University of Helsinki, Helsinki 00014, Finland; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Palotie A; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki 00290, Finland; Department of Public Health, University of Helsinki, Helsinki 00014, Finland; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA., Freimer NB; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA., Collins FS; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA., Burant C; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland. Electronic address: markku.laakso@uef.fi., Wen X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: xwen@umich.edu.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2022 Oct 06; Vol. 109 (10), pp. 1727-1741. Date of Electronic Publication: 2022 Sep 01.
Autor:
Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Electronic address: mathias.gorski@klinik.uni-regensburg.de., Rasheed H; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland., Thomas LF; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; BioCore-Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA., Sveinbjornsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Günther F; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany; Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, Munich, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, USA., Wuttke M; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany; Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany., Li Y; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany., Tin A; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, Mississippi, USA; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Ahluwalia TS; Steno Diabetes Center Copenhagen, Gentofte, Denmark; The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Ärnlöv J; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Stockholm, Sweden., Åsvold BO; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Bakker SJL; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Bansal N; Division of Nephrology, University of Washington, Seattle, Washington, USA; Kidney Research Institute, University of Washington, Seattle, Washington, USA., Biggs ML; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Böhnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, Germany., Brumpton B; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Carroll RJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Chaker L; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Chalmers J; The George Institute for Global Health, University of New South Wales, Sydney, Australia., Chee ML; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore., Chee ML; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Chu AY; Genetics, Merck & Co, Inc., Kenilworth, New Jersey, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Italy., Cocca M; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo,' Trieste, Italy., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Cusi D; Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy; Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy., de Borst MH; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Eckardt KU; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany., Endlich K; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, Maryland, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy., Gampawar P; Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria., Gansevoort RT; Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Ghasemi S; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Giedraitis V; Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Gieger C; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Gudbjartsson DF; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland; Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Hallan S; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Nephrology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Hamet P; Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada; Medpharmgene, Montreal, Quebec, Canada; CRCHUM, Montreal, Quebec, Canada., Hishida A; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ho K; Kidney Health Research Institute (KHRI), Geisinger, Danville, Pennsylvania, USA; Department of Nephrology, Geisinger, Danville, Pennsylvania, USA., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Holleczek B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Holm H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Hoppmann A; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany., Horn K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Hveem K; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hwang SJ; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Josyula NS; Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, Maryland, USA., Jung B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany; KfH Kidney Centre Traunstein, Traunstein, Germany., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Karabegović I; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Khor CC; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Kramer H; Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, USA; Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, Illinois, USA., Krämer BK; Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Kühnel B; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Kuusisto J; Department of Medicine, Kuopio University Hospital, Kuopio, Finland; Centre for Medicine and Clinical Research, University of Eastern Finland School of Medicine, Kuopio, Finland., Laakso M; Department of Medicine, Kuopio University Hospital, Kuopio, Finland; Centre for Medicine and Clinical Research, University of Eastern Finland School of Medicine, Kuopio, Finland., Lange LA; Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Li M; Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, Utah, USA., Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Wellcome Center for Human Genetics, University of Oxford, Oxford, UK; Nuffield Department of Women's and Reproductive Health, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford, UK; Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford, UK., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lukas MA; Clinical Sciences, GlaxoSmithKline, Albuquerque, New Mexico, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mahajan A; Wellcome Center for Human Genetics, University of Oxford, Oxford, UK; Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Matias-Garcia PR; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; TUM School of Medicine, Technical University of Munich, Munich, Germany., Meisinger C; Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, Augsburg, Germany., Meitinger T; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany., Melander O; Hypertension and Cardiovascular Disease, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, the Netherlands., Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Morris AP; Department of Health Data Science, University of Liverpool, Liverpool, UK; Wellcome Center for Human Genetics, University of Oxford, Oxford, UK; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Mychaleckyj JC; Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, Virginia, USA., Nadkarni GN; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Naito M; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Oral Epidemiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA; Data Tecnica International, Glen Echo, Maryland, USA., Nauck M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Ning B; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy., O'Donoghue ML; Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA; TIMI Study Group, Boston, Massachusetts, USA., O'Connell J; University of Maryland School of Medicine, Baltimore, Maryland, USA., Olafsson I; Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland., Orho-Melander M; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Parsa A; Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Pendergrass SA; Geisinger Research, Biomedical and Translational Informatics Institute, Danville, Pennsylvania, USA., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, the Netherlands., Pirastu M; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Services, University of Washington, Seattle, Washington, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Rheinberger M; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany; KfH Kidney Centre Traunstein, Traunstein, Germany., Rice KM; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Rizzi F; Department of Health Sciences, University of Milan, Milano, Italy; ePhood Scientific Unit, ePhood SRL, Milano, Italy., Rosenkranz AR; Division of Nephrology, Department of Internal Medicine, Medical University Graz, Graz, Austria., Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Italy., Ryan KA; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Salvi E; Department of Health Sciences, University of Milan, Milano, Italy; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta,' Milan, Italy., Schmidt H; Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, Germany., Schulz CA; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Sedaghat S; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA., Shaffer CM; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sieber KB; Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Sims M; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Stanzick KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Thorsteinsdottir U; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Stocker H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University, Mainz, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Sulem P; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Szymczak S; Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany; Institute of Medical Biometry and Statistics, University of Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Thio CHL; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Tremblay J; Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada; CRCHUM, Montreal, Quebec, Canada; Medpharmgene, Montreal, Quebec, Canada., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wakai K; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Wallentin L; Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden., Wallner S; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany., Wang J; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Waterworth DM; Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA., White HD; Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Woodward M; The George Institute for Global Health, University of New South Wales, Sydney, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; The George Institute for Global Health, University of Oxford, Oxford, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Yerges-Armstrong LM; Human Genetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Zimmermann M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, Maryland, USA., Bergler T; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany; KfH Kidney Centre Traunstein, Traunstein, Germany., Pattaro C; Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy., Köttgen A; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Kronenberg F; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Electronic address: iris.heid@klinik.uni-regensburg.de.
Publikováno v:
Kidney international [Kidney Int] 2022 Sep; Vol. 102 (3), pp. 624-639. Date of Electronic Publication: 2022 Jun 16.