Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.

Autor: Ibanez L; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Heitsch L; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Emergency Medicine, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8072; Saint Louis (63110), Missouri, US., Carrera C; Stroke Unit, Vall d'Hebron University Hospital, Universitat de Barcelona, Passeig de la Vall d'Hebron, 1198; Barcelona (08035), Spain., Farias FHG; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Dhar R; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US., Budde J; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Bergmann K; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Bradley J; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Harari O; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue; Saint Louis (63110), Missouri, US.; Department of Neuroscience, Katholieke Universiteit Leuven, Campus Gasthuisberg O&N2; Herestraat 49 box 1021; Leuven (BE-3000), Belgium., Phuah CL; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US., Lemmens R; Department of Neuroscience, Katholieke Universiteit Leuven, Campus Gasthuisberg O&N2; Herestraat 49 box 1021; Leuven (BE-3000), Belgium., Souza AAVO; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), R. Tessalia Viera de Camargo, 126; Cidade Universitaria, Campinas (13083-887), Brazil.; Brazilian Institute of Neuroscience and Neurotecnology (BRAINN), R. Tessalia Viera de Camargo, 126; Cidade Universitaria, Campinas (13083-887), Brazil., Moniche F; Department of neurology, Hospital Virgen del Rocio, University of Seville, Avenida Manuel Siurot, s/n; Seville (41013), Spain., Cabezas-Juan A; Department of neurology, Hospital Virgen del Rocio, University of Seville, Avenida Manuel Siurot, s/n; Seville (41013), Spain.; Hospital Virgen de la Macarena, University of Seville, Calle Dr. Fedriani, 3; Seville (41009), Spain., Arenillas JF; Department of Neurology, Hospital Clinico Universitario Valladolid, Valladolid University, Avenida Ramon y Cajal, 3; Valladolid (47003), Spain., Krupinksi J; Department of Neurology, Mutua Terrassa University Hospital, Universitat de Barcelona, Plaça del Dr. Robert, 5; Terrassa (08221), Spain.; Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona, Carrer Sant Antoni, 19; Terrassa (08221), Spain., Cullell N; Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona, Carrer Sant Antoni, 19; Terrassa (08221), Spain.; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Torres-Aguila N; Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona, Carrer Sant Antoni, 19; Terrassa (08221), Spain.; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Muiño E; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Cárcel-Márquez J; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Marti-Fabregas J; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Delgado-Mederos R; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Marin-Bueno R; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Hornick A; Department of Neurology, Southern Illinois Healthcare Memorial Hospital of Carbondale, 405 W Jackson Street, Carbondale (62901), Illinois, US., Vives-Bauza C; Department of Biology, Universitat de les Illes Balears, Carretera de Valldemossa, km 7,5, Palma (07122), Spain., Navarro RD; Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears, Carretera de Valldemossa, 79, Palma (07120), Spain., Tur S; Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears, Carretera de Valldemossa, 79, Palma (07120), Spain., Jimenez C; Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears, Carretera de Valldemossa, 79, Palma (07120), Spain., Obach V; Department of Neurology, Hospital Clinic de Barcelona, Universitat de Barcelona, Carrer Villarroel, 170, Barcelona (08036), Spain., Segura T; Research Unit, Complejo Hospitalario Universitario de Albacete. Calle Laurel s/n. Albacete (02008), Spain., Serrano-Heras G; Research Unit, Complejo Hospitalario Universitario de Albacete. Calle Laurel s/n. Albacete (02008), Spain., Chung JW; Department of Neurology, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, South Korea., Roquer J; Neurovascular Research Group, Institut Hospital del Mar de Investigations Mediques, Passeig Maritim, 25-29, Barcelona (08003), Spain., Soriano-Tarraga C; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; Neurovascular Research Group, Institut Hospital del Mar de Investigations Mediques, Passeig Maritim, 25-29, Barcelona (08003), Spain., Giralt-Steinhauer E; Neurovascular Research Group, Institut Hospital del Mar de Investigations Mediques, Passeig Maritim, 25-29, Barcelona (08003), Spain., Mola-Caminal M; Neurovascular Research Group, Institut Hospital del Mar de Investigations Mediques, Passeig Maritim, 25-29, Barcelona (08003), Spain.; Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, 75185, Sweden., Pera J; Department of Neurology, Jagiellonian University, Golebia, 24, Krakow(31-007), Poland., Lapicka-Bodzioch K; Department of Neurology, Jagiellonian University, Golebia, 24, Krakow(31-007), Poland., Derbisz J; Department of Neurology, Jagiellonian University, Golebia, 24, Krakow(31-007), Poland., Davalos A; Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Carretera de Canyet, s/n; Badalona (08916), Spain., Lopez-Cancio E; Department of Neurology, Hospital Universitario Central de Asturias, Oviedo, Spain., Muñoz L; Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Carretera de Canyet, s/n; Badalona (08916), Spain., Tatlisumak T; Department of Neurology, Sahlgrenska University Hospital, University of Gothenburg, Bla straket, 5; Gothenburg (413 45), Sweden.; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Molina C; Stroke Unit, Vall d'Hebron University Hospital, Universitat de Barcelona, Passeig de la Vall d'Hebron, 1198; Barcelona (08035), Spain., Ribo M; Stroke Unit, Vall d'Hebron University Hospital, Universitat de Barcelona, Passeig de la Vall d'Hebron, 1198; Barcelona (08035), Spain., Bustamante A; Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Carretera de Canyet, s/n; Badalona (08916), Spain., Sobrino T; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Castillo-Sanchez J; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Campos F; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Rodriguez-Castro E; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Arias-Rivas S; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Rodríguez-Yáñez M; Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Avda. Travesa da Choupana s/n; Santiago de Compostela (15706), Spain., Herbosa C; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US., Ford AL; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Department of Radiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US., Arauz A; Instituto Nacional de Neurologia y Neurocirurgia de Mexico, Avenida Insurgentes Sur 3877, Ciudad de Mexico (14269), Mexico., Lopes-Cendes I; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), R. Tessalia Viera de Camargo, 126; Cidade Universitaria, Campinas (13083-887), Brazil.; Brazilian Institute of Neuroscience and Neurotecnology (BRAINN), R. Tessalia Viera de Camargo, 126; Cidade Universitaria, Campinas (13083-887), Brazil., Lowenkopf T; Department of Neurology, Providence St. Vincent Medical Center, 9205 SW Barnes Rd, Portland (97225), Oregon, US., Barboza MA; Neurosciences Department, Hospital Rafael A. Calderon Guardia, Avenidas 7 y 9, calles 15 y 17, Aranjuez, San José, Costa Rica., Amini H; Department of Neurology and MIND Institute, University of California at Davis, 2825 5 street, Sacramento (95817), California, US., Stamova B; Department of Neurology and MIND Institute, University of California at Davis, 2825 5 street, Sacramento (95817), California, US., Ander BP; Department of Neurology and MIND Institute, University of California at Davis, 2825 5 street, Sacramento (95817), California, US., Sharp FR; Department of Neurology and MIND Institute, University of California at Davis, 2825 5 street, Sacramento (95817), California, US., Kim GM; Department of Neurology, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, South Korea., Bang OY; Department of Neurology, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, South Korea., Jimenez-Conde J; Neurovascular Research Group, Institut Hospital del Mar de Investigations Mediques, Passeig Maritim, 25-29, Barcelona (08003), Spain., Slowik A; Department of Neurology, Jagiellonian University, Golebia, 24, Krakow(31-007), Poland., Stribian D; Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4 Rakennus 1, Helsinki (00290), Finland., Tsai EA; Translational Biology, Biogen, Inc, 115 Brodway, Cambridge (02142), Massachusetts, US., Burkly LC; Genetics and Neurodevelomental Disease Research Unit, Biogen, Inc, 115 Brodway, Cambridge (02142), Massachusetts, US., Montaner J; Stroke Unit, Vall d'Hebron University Hospital, Universitat de Barcelona, Passeig de la Vall d'Hebron, 1198; Barcelona (08035), Spain.; Department of neurology, Hospital Virgen del Rocio, University of Seville, Avenida Manuel Siurot, s/n; Seville (41013), Spain.; Hospital Virgen de la Macarena, University of Seville, Calle Dr. Fedriani, 3; Seville (41009), Spain., Fernandez-Cadenas I; Stroke Unit, Vall d'Hebron University Hospital, Universitat de Barcelona, Passeig de la Vall d'Hebron, 1198; Barcelona (08035), Spain.; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Carrer de Sant Quinti, 89; Barcelona (08041), Spain., Lee JM; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Department of Radiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; Department of Biomedical Engineering, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; Stroke and Cerebrovascular Center, Washington University School of Medicine, One Barnes-Jewish Hospital Plaza, Saint Louis (63110), Missouri, US., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; NeuroGenomics and Informatics, Washington University School of Medicine, 425 S. Euclid Avenue, Saint Louis (63110), Missouri, US.; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Avenue; Campus Box 8111; Saint Louis (63110), Missouri, US.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue; Saint Louis (63110), Missouri, US.; Department of Genetics, Washington University School of Medicine, 4515 McKinley Ave, Saint Louis (63110), Missouri, US.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2020 Nov 03. Date of Electronic Publication: 2020 Nov 03.