IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer.

Autor: Heon EK; University of Maryland Medical Center, Baltimore, MD 21201, United States., Wulan H; Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853, China., Macdonald LP; Brown University, Providence, RI 02912, United States., Malek AO; Brown University, Providence, RI 02912, United States., Braunstein GH; Brown University, Providence, RI 02912, United States., Eaves CG; Brown University, Providence, RI 02912, United States., Schattner MD; Brown University, Providence, RI 02912, United States., Allen PM; University of Wisconsin, Madison, WI 53706, United States., Alexander MO; University of Wisconsin, Madison, WI 53706, United States., Hawkins CA; University of Wisconsin, Madison, WI 53706, United States., McGovern DW; University of Wisconsin, Madison, WI 53706, United States., Freeman RL; University of Wisconsin, Madison, WI 53706, United States., Amir EP; University of Illinois, Chicago, IL 60607, United States., Huse JD; University of Illinois, Chicago, IL 60607, United States., Zaltzman JS; University of Texas, Austin, TX 78712, United States., Kauff NP; University of Texas, Austin, TX 78712, United States., Meyers PG; University of Texas, Austin, TX 78712, United States., Gleason MH; University of Texas, Austin, TX 78712, United States. Electronic address: GleasonM@cblabs.org., Overholtzer MG; University of Texas, Austin, TX 78712, United States. Electronic address: OverholtzerM@cblabs.org., Wiseman SS; Ohio State University, Columbus, OH 43210, United States., Streutker CD; Ohio State University, Columbus, OH 43210, United States., Asa SW; Ohio State University, Columbus, OH 43210, United States., McAlindon TP; Ohio State University, Columbus, OH 43210, United States., Newcomb PO; University of Illinois, Chicago, IL 60607, United States. Electronic address: Polly.Newcomb@mcgene.org., Sorensen PM; University of Illinois, Chicago, IL 60607, United States. Electronic address: Poul.Sorensen@mcgene.org., Press OA; University of Illinois, Chicago, IL 60607, United States. Electronic address: Oliver.Press@mcgene.org.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2015 Aug 14; Vol. 464 (1), pp. 360-6. Date of Electronic Publication: 2015 Jun 30.

S-15 in combination of Akt inhibitor promotes the expansion of CD45RA⁻CCR7⁺ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1⁺Tim-3⁺ cells as well as regulatory T cells.

Autor: Xu, Benling¹ (AUTHOR), Yuan, Long² (AUTHOR), Chen, Guangyu¹ (AUTHOR), Li, Tiepeng¹ (AUTHOR), Zhou, Jinxue³ (AUTHOR), Zhang, Chengjuan¹ (AUTHOR), Qin, Peng¹ (AUTHOR), Muthana, Musleh M.⁴ (AUTHOR), Wang, Shengdian⁵ (AUTHOR) sdwang@ibp.ac.cn, Du, Xuexiang¹ (AUTHOR) dudu-ling@163.com, Gao, Quanli¹ (AUTHOR) gaoquanli1@aliyun.com

Publikováno v: Cancer Cell International. 12/3/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p.