RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.

Autor: Chen F; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Gurler SB; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Novo D; Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Selli C; Applied Bioinformatics of Cancer, Institute of Genetics and Cancer, University of Edinburgh Cancer Research Centre, Edinburgh, UK., Alferez DG; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Eroglu S; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Pavlou K; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Zhang J; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Sims AH; Applied Bioinformatics of Cancer, Institute of Genetics and Cancer, University of Edinburgh Cancer Research Centre, Edinburgh, UK., Humphreys NE; Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Adamson A; Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Campbell A; Cancer Research UK Beatson Institute, Glasgow, UK., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Tournier C; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Clarke RB; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Brennan K; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Streuli CH; Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Ucar A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. ahmet.ucar@manchester.ac.uk.

Publikováno v: Oncogene [Oncogene] 2023 Feb; Vol. 42 (9), pp. 679-692. Date of Electronic Publication: 2023 Jan 05.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Autor: Eccles, SA, Aboagye, EO, Ali, S, Anderson, AS, Armes, J, Berditchevski, F, Blaydes, JP, Brennan, K, Brown, NJ, Bryant, HE, Bundred, NJ, Burchell, JM, Campbell, AM, Carroll, JS, Clarke, RB, Coles, CE, Cook, GJR, Cox, A, Curtin, NJ, Dekker, LV, Silva, IS, Duffy, SW, Easton, DF, Eccles, DM, Edwards, DR, Edwards, J, Evans, DG, Fenlon, DF, Flanagan, JM, Foster, C, Gallagher, WM, Garcia-Closas, M, Gee, JMW, Gescher, AJ, Goh, V, Groves, AM, Harvey, AJ, Harvie, M, Hennessy, BT, Hiscox, S, Holen, I, Howell, SJ, Howell, A, Hubbard, G, Hulbert-Williams, N, Hunter, MS, Jasani, B, Jones, LJ, Key, TJ, Kirwan, CC, Kong, A, Kunkler, IH, Langdon, SP, Leach, MO, Mann, DJ, Marshall, JF, Martin, LA, Martin, SG, Macdougall, JE, Miles, DW, Miller, WR, Morris, JR, Moss, SM, Mullan, P, Natrajan, R, O’Connor, JPB, O’Connor, R, Palmieri, C, Pharoah, PDP, Rakha, EA, Reed, E, Robinson, SP, Sahai, E, Saxton, JM, Schmid, P, Smalley, MJ, Speirs, V, Stein, R, Stingl, J, Streuli, CH, Tutt, ANJ, Velikova, G, Walker, RA, Watson, CJ, Williams, KJ, Young, LS, Thompson, AM

Publikováno v: Eccles, S A, Aboagye, E O, Ali, S, Anderson, A S, Armes, J, Berditchevski, F, Blaydes, J P, Brennan, K, Brown, N J, Bryant, H E, Bundred, N J, Burchell, J M, Campbell, A M, Carroll, J S, Clarke, R B, Coles, C E, Cook, G J, Cox, A, Curtin, N J, Dekker, L V, Dos Santos Silva, I, Duffy, S W, Easton, D F, Eccles, D M, Edwards, D R, Edwards, J, Evans, D, Fenlon, D F, Flanagan, J M, Foster, C, Gallagher, W M, Garcia-closas, M, Gee, J M W, Gescher, A J, Goh, V, Groves, A M, Harvey, A J, Harvie, M, Hennessy, B T, Hiscox, S, Holen, I, Howell, S J, Howell, A, Hubbard, G, Hulbert-williams, N, Hunter, M S, Jasani, B, Jones, L J, Key, T J, Kirwan, C C, Kong, A, Kunkler, I H, Langdon, S P, Leach, M O, Mann, D J, Marshall, J F, Martin, L, Martin, S G, Macdougall, J E, Miles, D W, Miller, W R, Morris, J R, Moss, S M, Mullan, P, Natrajan, R, O'Connor, J P, O'Connor, R, Palmieri, C, Pharoah, P D P, Rakha, E A, Reed, E, Robinson, S P, Sahai, E, Saxton, J M, Schmid, P, Smalley, M J, Speirs, V, Stein, R, Stingl, J, Streuli, C H, Tutt, A N J, Velikova, G, Walker, R A, Watson, C J, Williams, K J, Young, L S & Thompson, A M 2013, ' Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer ', Breast Cancer Research, vol. 15, no. 5, pp. R92 . https://doi.org/10.1186/bcr3493
Eccles, S A, Aboagye, E O, Ali, S, Anderson, A S, Armes, J, Berditchevski, F, Blaydes, J P, Brennan, K, Brown, N J, Bryant, H E, Bundred, N J, Burchell, J M, Campbell, A M, Carroll, J S, Clarke, R, Coles, C E, Cook, G J R, Cox, A, Curtin, N J, Dekker, L V, dos Santos Silva, I, Duffy, S W, Easton, D F, Eccles, D M, Edwards, D R, Edwards, J, Evans, D G, Fenlon, D F, Flanagan, J M, Foster, C, Gallagher, W M, Garcia-Closas, M, Gee, J M W, Gescher, A J, Goh, V, Groves, A M, Harvey, A J, Harvie, M, Hennessy, B T, Hiscox, S, Holen, I, Howell, S J, Howell, A, Hubbard, G, Hulbert-Williams, N, Hunter, M S, Jasani, B, Jones, L J, Key, T J, Kirwan, C C, Kong, A, Kunkler, I H, Langdon, S P, Leach, M O, Mann, D J, Marshall, J F, Martin, L A, Martin, S G, Macdougall, J E, Miles, D W, Miller, W R, Morris, J R, Moss, S M, Mullan, P, Natrajan, R, O'Connor, J P B, O'Connor, R, Palmieri, C, Pharoah, P D P, Rakha, E A, Reed, E, Robinson, S P, Sahai, E, Saxton, J M, Schmid, P, Smalley, M J, Speirs, V, Stein, R, Stingl, J, Streuli, C H, Tutt, A N J, Velikova, G, Walker, R A, Watson, C J, Williams, K J, Young, L S & Thompson, A M 2013, ' Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer ', Breast Cancer Research, vol. 15, no. 5, R92 . https://doi.org/10.1186/bcr3493
Eccles, S A, Aboagye, E O, Ali, S, Anderson, A S, Armes, J, Berditchevski, F, Blaydes, J P, Brennan, K, Brown, N J, Bryant, H E, Bundred, N J, Burchell, J M, Campbell, A M, Carroll, J S, Clarke, R, Coles, C E, Cook, G J R, Cox, A, Curtin, N J, Dekker, L V, dos Santos Silva, I, Duffy, S W, Easton, D F, Eccles, D M, Edwards, D R, Edwards, J, Evans, D G, Fenlon, D F, Flanagan, J M, Foster, C, Gallagher, W M, Garcia-Closas, M, Gee, J M W, Gescher, A J, Goh, V, Groves, A M, Harvey, A J, Harvie, M, Hennessy, B T, Hiscox, S, Holen, I, Howell, S J, Howell, A, Hubbard, G, Hulbert-Williams, N, Hunter, M S, Jasani, B, Jones, L J, Key, T J, Kirwan, C C, Kong, A, Kunkler, I H, Langdon, S P, Leach, M O, Mann, D J, Marshall, J F, Martin, L A, Martin, S G, Macdougall, J E, Miles, D W, Miller, W R, Morris, J R, Moss, S M, Mullan, P, Natrajan, R, O'Connor, J P B, O'Connor, R, Palmieri, C, Pharoah, P D P, Rakha, E A, Reed, E, Robinson, S P, Sahai, E, Saxton, J M, Schmid, P, Smalley, M J, Speirs, V, Stein, R, Stingl, J, Streuli, C H, Tutt, A N J, Velikova, G, Walker, R A, Watson, C J, Williams, K J, Young, L S & Thompson, A M 2013, ' Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer ' Breast Cancer Research, vol. 15, no. 5, R92 . https://doi.org/10.1186/bcr3493

IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcba93ac48cd12f2f8cb52e44785339
https://ora.ox.ac.uk/objects/uuid:74a38e7b-a1ff-43ac-b628-b2c6e156538e

Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state

Autor: Maya-Mendoza, Apolinar, Merchut-Maya, J, Bartkova, J, Bartek, J, Streuli, CH, Jackson, Dean

Publikováno v: Cell Death & Disease
Maya-Mendoza, A, Merchut-Maya, J, Bartkova, J, Bartek, J, Streuli, CH & Jackson, D 2014, ' Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state ', CELL DEATH & DISEASE, vol. 5, e1351 . https://doi.org/10.1038/cddis.2014.315

Mammalian cells have mechanisms to counteract the effects of metabolic and exogenous stresses, many of that would be mutagenic if ignored. Damage arising during DNA replication is a major source of mutagenesis. The extent of damage dictates whether c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::30c0791b1961b70d06ffe98487b07b37
http://europepmc.org/articles/PMC4123104

Infection of human organoids supports an intestinal niche for Chlamydia trachomatis.

Autor: Hovhannisyan, Pargev¹ (AUTHOR), Stelzner, Kathrin¹ (AUTHOR), Keicher, Markus¹ (AUTHOR), Paprotka, Kerstin¹ (AUTHOR), Neyazi, Mastura² (AUTHOR), Pauzuolis, Mindaugas² (AUTHOR), Ali, Waled Mohammed¹ (AUTHOR), Rajeeve, Karthika^1,3 (AUTHOR), Bartfeld, Sina^2,4,5 (AUTHOR), Rudel, Thomas¹ (AUTHOR) thomas.rudel@uni-wuerzburg.de

Publikováno v: PLoS Pathogens. 8/22/2024, Vol. 20 Issue 8, p1-22. 22p.

Integrins and cell-fate determination

Autor: Streuli CH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2295::9a22258987a7d21e8f9c97bceecbffa5
http://www.pubmed.org/19118209