Molecular insights into the mechanism of substrate recognition of Streptomyces transglutaminases

Autor: Shota Tokai, Misugi Uraji, Tadashi Hatanaka

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 84:575-582

The microbial TGase from Streptomyces mobaraensis has used in various food industries. However, the detailed substrate specificities of TGases from the Streptomyces species toward the natural peptides remains to be unclear. In this study, we conducte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::247a7a8972a20c69bac9a60c66b6145f
https://doi.org/10.1080/09168451.2019.1697198

Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches

Autor: Jérôme Seguin, Emmanuel Favry, Isabelle Correia, Jean-Luc Pernodet, Sylvie Lautru, Jerzy Witwinowski, Laëtitia Caraty, Mireille Moutiez, Matthieu Coupet, Corinne Saulnier, Olivier Lequin, Muriel Gondry, Pascal Belin, Emmanuelle Darbon, Antonio C. Ruzzini

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.20226. ⟨10.1038/s41598-019-56747-7⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-56747-7⟩
Scientific Reports, 2019, 9 (1), pp.20226. ⟨10.1038/s41598-019-56747-7⟩

The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737ea58699d6e1abfd1d6af06e9a0677
https://hal.archives-ouvertes.fr/hal-02431235/document

Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes

Autor: Andrew W. Truman, Govind Chandra, Siobhán Dorai-Raj, Natalia M. Vior, Rodney Lacret, Martin Trick

Bicyclomycin (BCM) is a clinically promising antibiotic that is biosynthesised byStreptomyces cinnamoneusDSM 41675. BCM is structurally characterized by a core cyclo(L-Ile-L-Leu) 2,5-diketopiperazine (DKP) that is extensively oxidized. Here, we ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d619e1347375c66d0d7525c90c34b0e7

Insights into the Biosynthesis of Duramycin

Autor: Wilfred A. van der Donk, Liujie Huo, Ayşe Ökesli, Ming Zhao

Publikováno v: Applied and Environmental Microbiology. 83

Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial peptides that are characterized by the thioether cross-linked bisamino acids lanthionine (Lan) and methyllanthionine (MeLan). Duramycin contains 19 amino acids, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ec8046d3502c1390a64bd43fe92bc8
https://doi.org/10.1128/aem.02698-16

High-level production of mature active-form Streptomyces mobaraensis transglutaminase via pro-transglutaminase processing using Streptomyces lividans as a host

Autor: Shuhei Noda, Takaya Miyazaki, Tsutomu Tanaka, Ogino Chiaki, Akihiko Kondo

Publikováno v: Biochemical Engineering Journal. 74:76-80

Streptomyces mobaraensis transglutaminase (MTG) is one of the most useful transglutaminases due to its rather broad substrate specificity and independence of Ca2+. To achieve efficient production of active-form MTG using Streptomyces lividans as a ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b2e85b69ab27944cbe4e64c33ddb503
https://doi.org/10.1016/j.bej.2013.02.011