Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Autor: Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng

Publikováno v: Microbial Cell Factories, Vol 19, Iss 1, Pp 1-13 (2020)

Abstract Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal screening campaign, we identifie

Externí odkaz: https://doaj.org/article/ec0148909bdf449eae2f3e74c507b601

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Autor: Shawn Hoon, Alexander Lezhava, Fernanda L. Sirota, Sharon Crasta, Frank Eisenhaber, Zann Tan, Choy Eng Nge, Swaine L. Chen, Veronica Ng, Birgit Eisenhaber, Siew Bee Ng, Mingzi M. Zhang, Huibin Zhang, Chung Yan Leong, Kia Ngee Low, Falicia Goh, Fong Tian Wong, Tian Ru Lim, Wan Lin Yeo, Yoganathan Kanagasundaram, Elena Heng

Publikováno v: Microbial Cell Factories
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-13 (2020)

Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal screening campaign, we identified an alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b0c5a37711ad2bdbb7c223c45fec91
https://doi.org/10.1186/s12934-020-01328-x

Characterisation of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a nonsynonymous SNP in the Mycobacterium bovis BCG orthologue

Autor: Pablo Mendoza Lopez, Kevin C. Conlon, Julio Polaina, Antonio Suárez García, Stephen V. Gordon, Javier Nunez Garcia, R. Glyn Hewinson, Esen Wooff, M. Carmen Garcia Pelayo, Ana Camacho, Paul Golby

Publikováno v: Microbiology; Vol 156
Microbiology

A number of single-nucleotide polymorphisms (SNPs) have been identified in the genome of Mycobacterium bovis BCG Pasteur compared with the sequenced strain M. bovis 2122/97. The functional consequences of many of these mutations remain to be describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd90347ed4f2d8a7c7ff19b667f7471f

Engineered polyketides: Synergy between protein and host level engineering.

Autor: Barajas JF; Department of Energy Agile BioFoundry, Emeryville, CA, USA., Blake-Hedges JM; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Bailey CB; Joint BioEnergy Institute, Emeryville, CA 94608, USA.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Curran S; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Comparative Biochemistry Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA., Keasling JD; Joint BioEnergy Institute, Emeryville, CA 94608, USA.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; QB3 Institute, University of California, Berkeley, Emeryville, CA 94608, USA.; Department of Chemical & Biomolecular Engineering, Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.; Novo Nordisk Foundation Center for Biosustainability, Technical University Denmark, DK2970 Horsholm, Denmark.

Publikováno v: Synthetic and systems biotechnology [Synth Syst Biotechnol] 2017 Sep 07; Vol. 2 (3), pp. 147-166. Date of Electronic Publication: 2017 Sep 07 (Print Publication: 2017).