Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

The effects of experimental hyperglycaemia and hyperinsulinaemia on macrovascular endothelial cell function

Autor: Strembitska, Anastasiya

Publikováno v: IndraStra Global.

Endothelial dysfunction, characterised by decreased NO synthesis, is associated with an increased risk of cardiovascular complications in patients with type 1 diabetes mellitus, type 2 diabetes mellitus (T2DM) and insulin resistance. The dysfunctiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47aff7c1de7cdbd9e3536495112b5cfd
https://igi.indrastra.com/items/show/231869

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

Autor: Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek A., Kennedy, Simon, Palmer, Timothy M., Salt, Ian P.

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2) inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular outcomes. Whether SGLT2 inhibitors directly affect cardiovascular tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::57a9af7c13ac09a670e047be7948f383
https://eprints.gla.ac.uk/158937/7/158937.pdf

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487

Autor: Heathcote, Helen R., Mancini, Sarah J., Strembitska, Anastasiya, Jamal, Kunzah, Reihill, James A., Palmer, Timothy M., Gould, Gwyn W., Salt, Ian P.

Publikováno v: Heathcote, H R, Mancini, S J, Strembitska, A, Jamal, K, Reihill, J A, Palmer, T M, Gould, G W & Salt, I P 2016, ' Protein Kinase C phosphorylates AMP-activated protein kinase α1 Ser487 ', Biochemical Journal . https://doi.org/10.1042/BCJ20160211
Biochemical Journal

The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly characterised. Recent studies have identified phosphorylation of the AMPKα1/α2 catalytic subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9b30d490268a4c4efbdbb76ee4a6bb73
https://strathprints.strath.ac.uk/70181/1/Heathcote_etal_BJ2016_Protein_kinase_C_phosphorylates_AMP_activated_protein_kinase_1_Ser487.pdf