Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Autor: Christen, Lisa, Broghammer, Helen, Möhlis, Kevin, Strehlau, Christian, Ribas-Latre, Aleix, Gebhardt, Claudia, Roth, Lisa, Krause, Kerstin, Landgraf, Kathrin, Körner, Antje, Rohde-Zimmermann, Kerstin, Hoffmann, Anne, Klöting, Nora, Ghosh, Adhideb, Sun, Wenfei, Dong, Hua, Wolfrum, Christian, Rassaf, Tienush, Hendgen-Cotta, Ulrike B.

Publikováno v: Clinical and Translational Medicine, 12 (12)

Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases. Thermogenesis requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bc39b452a873c19da43e12a904441a
https://hdl.handle.net/20.500.11850/590317

Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.

Autor: Christen L; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Broghammer H; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Rapöhn I; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Möhlis K; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Strehlau C; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Ribas-Latre A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Gebhardt C; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Roth L; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Krause K; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Landgraf K; Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, Leipzig, Germany., Körner A; Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, Leipzig, Germany., Rohde-Zimmermann K; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Klöting N; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Ghosh A; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Sun W; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Dong H; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Wolfrum C; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Rassaf T; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Hendgen-Cotta UB; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Stumvoll M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Heiker JT; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Institute of Biochemistry, Faculty of Life Sciences, University of Leipzig, Leipzig, Germany., Weiner J; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Dec; Vol. 12 (12), pp. e1108.