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Akademický článek

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.

Autor: Winn BA; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Devkota L; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Kuch B; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., MacDonough MT; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Strecker TE; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Wang Y; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Shi Z; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Gerberich JL; Predictive Imaging Research Laboratory, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9058, United States., Mondal D; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Ramirez AJ; Mass Spectrometry Center, Baylor University, One Bear Place #97046, Waco, Texas 76798-7046, United States., Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States., Chaplin DJ; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States.; Fast Biopharma Ltd., 10 Aston Park, Aston Rowant, OX49 5SW, United Kingdom., Davis P; Fast Biopharma Ltd., 10 Aston Park, Aston Rowant, OX49 5SW, United Kingdom., Mason RP; Predictive Imaging Research Laboratory, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9058, United States., Trawick ML; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States., Pinney KG; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States.

Publikováno v: Journal of natural products [J Nat Prod] 2020 Apr 24; Vol. 83 (4), pp. 937-954. Date of Electronic Publication: 2020 Mar 20.

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Akademický článek

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.

Autor: Niu H; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States., Strecker TE; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States., Gerberich JL; Department of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , Texas 75390-9058 , United States., Campbell JW 3rd; Department of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , Texas 75390-9058 , United States., Saha D; Department of Radiology Oncology, Division of Molecular Radiation Biology , The University of Texas Southwestern Medical Center , 2201 Inwood Road , Dallas , Texas 75390-9187 , United States., Mondal D; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States., Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis , National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health , Frederick , Maryland 21702 , United States., Chaplin DJ; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States.; Mateon Therapeutics, Inc. , 701 Gateway Boulevard, Suite 210 , South San Francisco , California 94080 , United States., Mason RP; Department of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , Texas 75390-9058 , United States., Trawick ML; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States., Pinney KG; Department of Chemistry and Biochemistry , Baylor University , One Bear Place, No. 97348 , Waco , Texas 76798-7348 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Jun 13; Vol. 62 (11), pp. 5594-5615. Date of Electronic Publication: 2019 May 24.

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Akademický článek

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

Autor: Maguire CJ; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117., Carlson GJ; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117., Ford JW; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117., Strecker TE; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117., Hamel E; Screening Technologies Branch , Developmental Therapeutics Program , Division of Cancer Treatment and Diagnosis , National Cancer Institute , Frederick National Laboratory for Cancer Research , National Institutes of Health , Frederick , MD 21702 , USA., Trawick ML; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117., Pinney KG; Department of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.

Publikováno v: MedChemComm [Medchemcomm] 2019 Jun 04; Vol. 10 (8), pp. 1445-1456. Date of Electronic Publication: 2019 Jun 04 (Print Publication: 2019).

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