Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Streamson C Chua"'
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2004399 (2018)
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient
Externí odkaz:
https://doaj.org/article/0310a5c47dbd47f3aa807dd68e1954d5
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89199 (2014)
Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-spe
Externí odkaz:
https://doaj.org/article/df3c7b52d9fa41888b3963774e03df65
Publikováno v:
J Biol Chem
The hormone leptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)
Publikováno v:
Trends Endocrinol Metab
Obesity is a neurological disorder that operates by favoring energy storage within adipose depots and increased caloric intake. Most cases of human obesity are acquired without any underlying genetic basis. Here, we suggest that obesity can impair th
Publikováno v:
Am J Physiol Endocrinol Metab
The arcuate nucleus (ARC) of the hypothalamus comprises two antagonistic neuron populations critical for energy balance, namely, the anorexigenic pro-opiomelanocortin (POMC) and the orexigenic agouti-related peptide (AgRP) neurons that act as agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbd182c588c88ddf5b58882a603da6
https://europepmc.org/articles/PMC7988782/
https://europepmc.org/articles/PMC7988782/
Autor:
Shun Mei Liu, Hye Young Joung, Eunjin Kwon, Gary J. Schwartz, Streamson C. Chua, Young Hwan Jo
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The central melanocortin system plays a fundamental role in the control of feeding and body weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent an
Autor:
Streamson C. Chua, Rudolph Leibel
Publikováno v:
The Genetics of Obesity ISBN: 9781003068242
The Genetics of Obesity
The Genetics of Obesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c857c08b721bc33e408dfb8b244468
https://doi.org/10.1201/9781003068242-15
https://doi.org/10.1201/9781003068242-15
Autor:
Richard N. Kitsis, Yun Chen, Jeremy Weinberger, David A. Lomas, Min Zheng, Wilson Lek Wen Tan, Wendy M. McKimpson, Jeffrey E. Pessin, Zenia Tiang, Alistair M. Jagger, Roger Foo, Streamson C. Chua, James A. Irving
Publikováno v:
Developmental cell. 56(6)
Loss of insulin-secreting pancreatic β cells through apoptosis contributes to the progression of type 2 diabetes, but underlying mechanisms remain elusive. Here, we identify a pathway in which the cell death inhibitor ARC paradoxically becomes a kil
Autor:
Tamara A. Kucaba, Britnie R. James, Thomas S. Griffith, Andrew Wilber, Frances V. Sjaastad, Katherine A. Murphy, Hyunjoon Kim, Erik L. Brincks, Streamson C. Chua
Publikováno v:
The Journal of Immunology. 201:1837-1841
Various malignancies are reproducibly cured in mouse models, but most cancer immunotherapies show objective responses in a fraction of treated patients. One reason for this disconnect may be the use of young, lean mice lacking immune-altering comorbi
Autor:
Genevieve Marcelin, Streamson C. Chua, Young Hwan Jo, Gary J. Schwartz, Jae Hoon Jeong, Clemence Blouet, Shun-Mei Liu
Publikováno v:
Molecular Metabolism, Vol 8, Iss, Pp 37-50 (2018)
Molecular Metabolism
Molecular Metabolism
Objective Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons.