Výsledky vyhledávání

Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus–mediated transfer of the VLDL receptor gene

Autor: M Donahee, J F Strauss rd, James M. Wilson, Karin Jooss, Karen F. Kozarsky

Publikováno v: Nature Genetics. 13:54-62

Liver directed gene transfer with adenoviral vectors is being considered for the treatment of several metabolic diseases, including familial hypercholesterolaemia (FH). Gene replacement therapy of human low density lipoprotein (LDL) receptor gene int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e6e5d815b8c4531782b676e08a178e
https://doi.org/10.1038/ng0596-54

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The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

Autor: Dudley K. Strickland, Frances D. Battey, M.E. Gåfvels, J.F. Strauss rd, Desmond J. Fitzgerald, D.A. Chappell, William Scott Argraves

Publikováno v: Journal of Biological Chemistry. 269:23268-23273

A 39-kDa receptor associated protein (RAP) binds and inhibits ligand binding by two members of the low density lipoprotein (LDL) receptor family, gp330 and low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa3b3483d1a69075230354e5b1b0b70a
https://doi.org/10.1016/s0021-9258(17)31648-4

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The Human 'Peripheral-Type' Benzodiazepine Receptor: Regional Mapping of the Gene and Characterization of the Receptor Expressed from cDNA

Autor: Y J Chang, Beverly S. Emanuel, J F Strauss rd, R T McCabe, Hanna Rennert, R Sayegh, Phil Skolnick, M L Budarf

Publikováno v: DNA and Cell Biology. 11:471-480

A cDNA for the human "peripheral-type" benzodiazepine receptor (PBR) was isolated from a liver cDNA library. The 851-nucleotide probe hybridized with a approximately 1 kb mRNA in Northern blots of RNA extracted from various human tissues and cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d76c431014d96ec0733b407d00a5474
https://doi.org/10.1089/dna.1992.11.471

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Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by human chorionic gonadotropin, cyclic AMP, and sterol

Autor: A M August, Thaddeus G. Golos, J F Strauss rd

Publikováno v: Journal of Lipid Research, Vol 27, Iss 10, Pp 1089-1096 (1990)

Steroidogenic cells utilize lipoprotein-delivered cholesterol as a primary substrate for hormone synthesis. We studied low density lipoprotein (LDL) receptors in cultured human granulosa cells to determine what factors regulate receptor expression. G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df7298928696530b76ae0c7e2222b58
https://doi.org/10.1016/s0022-2275(20)38766-6

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Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene

Autor: J F Strauss rd, Kenji Fujieda, K Tachibana, Teruo Sugawara, S Suwa, Jun Nakae, S Sageshima, T Tajima

Publikováno v: The Journal of clinical investigation. 99(6)

Congenital lipoid adrenal hyperplasia (lipoid CAH) is the most severe form of CAH in which the synthesis of all gonadal and adrenal cortical steroids is markedly impaired. We report here the clinical, endocrinological, and molecular analyses of two u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f786ecf0ffef7535dfacaea81a1e
https://pubmed.ncbi.nlm.nih.gov/9077535

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Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene

Autor: Marianthi Kiriakidou, J F Strauss rd, John A. Holt, Teruo Sugawara

Publikováno v: Biochemistry. 35(28)

Steroidogenic acute regulatory protein (StAR) is required for efficient adrenal cortical and gonadal but not trophoblast steroid hormone synthesis. StAR gene expression in gonadal cells is stimulated by tropic hormones acting through the intermediacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c92eb18689ef5f9574082ffa217562
https://pubmed.ncbi.nlm.nih.gov/8703908

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Akademický článek

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Hepatic lipase. Synthesis, processing, and secretion by isolated rat hepatocytes

Autor: H.M. Laboda, Jane M. Glick, J.F. Strauss rd, E.A. Laposata

Publikováno v: Journal of Biological Chemistry. 262:5333-5338

Hepatic lipase, a glycoprotein synthesized and secreted by the hepatocyte, binds to sinusoidal endothelium where it is involved in metabolism of lipoprotein phospholipid and triglyceride. To better understand the regulation of hepatic lipase, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad26906375379910254490bab3977212
https://doi.org/10.1016/s0021-9258(18)61192-5

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Lipid metabolism in regressing rat corpora lutea of pregnancy

Autor: E Seifter, J F Strauss rd, E L Lien, David B. P. Goodman, R L Stambaugh

Publikováno v: Journal of Lipid Research, Vol 18, Iss 2, Pp 246-258 (1977)

Lipid accumulation is a hallmark of corpus luteum regression and we characterized lipids stored in rat corpora lutea of pregnancy between days 21 and 24 post coitum, the period of luteolysis. A 10-fold rise in lutein triglyceride concentrations occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e023a2ff7680eee9ffda8ea341eb76
https://doi.org/10.1016/s0022-2275(20)41704-3

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