Polo-like kinase 1 inhibition in NSCLC: mechanism of action and emerging predictive biomarkers

Autor: Stratmann JA, Sebastian M

Publikováno v: Lung Cancer: Targets and Therapy, Vol Volume 10, Pp 67-80 (2019)

Jan A Stratmann, Martin SebastianDepartment of Internal Medicine II, University Clinic of Frankfurt, 60596 Frankfurt, GermanyAbstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Due to often unspecific disease

Externí odkaz: https://doaj.org/article/de8eaf3055364c7d9ff3222bea2226f1

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Concepts of lines of therapy in cancer treatment: findings from an expert interview-based study.

Autor: Falchetto L; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany., Bender B; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany. B.Bender@med.uni-frankfurt.de.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany. B.Bender@med.uni-frankfurt.de., Erhard I; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany., Zeiner KN; Department for Dermatology, Venerology and Allergology, University Hospital Frankfurt, Frankfurt, Germany., Stratmann JA; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Koll FJ; Department of Urology, University Hospital Frankfurt, Frankfurt, Germany., Wagner S; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Reiser M; PIOH Praxis Internistischer Onkologie und Hämatologie, Cologne, Germany., Gasimli K; Clinic for Gynecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany., Stehle A; Department for Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany., Voss M; Department Neuro-Oncology, University Hospital Frankfurt, Frankfurt, Germany., Ballo O; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Vehreschild JJ; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany.; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF) partner site Bonn Cologne, Cologne, Germany., Maier D; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Publikováno v: BMC research notes [BMC Res Notes] 2024 May 15; Vol. 17 (1), pp. 137. Date of Electronic Publication: 2024 May 15.

Evolutionary trajectories of small cell lung cancer under therapy.

Autor: George J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. jgeorge@uni-koeln.de.; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University Hospital of Cologne, Cologne, Germany. jgeorge@uni-koeln.de., Maas L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Abedpour N; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Cancer Research Centre Cologne Essen, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Cartolano M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Kaiser L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Fischer RN; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Scheel AH; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Weber JP; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Hellmich M; Institute of Medical Statistics, and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Bosco G; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Volz C; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Mueller C; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University Hospital of Cologne, Cologne, Germany., Dahmen I; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., John F; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Alves CP; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Panse JP; Department of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Centre for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Kirschner M; Department of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Centre for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Engel-Riedel W; Department of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany., Jürgens J; Department of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany., Stoelben E; Thoraxclinic Cologne, Thoracic Surgery, St. Hildegardis-Krankenhaus, Cologne, Germany., Brockmann M; Department of Pathology, City of Cologne Municipal Hospitals, Witten/Herdecke University, Cologne, Germany., Grau S; Department of General Neurosurgery, Centre of Neurosurgery, University Hospital Cologne, Cologne, Germany.; University Medicine Marburg - Campus Fulda, Department of Neurosurgery, Fulda, Germany., Sebastian M; Department of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany.; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany., Stratmann JA; Department of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany., Kern J; Klinikum Würzburg Mitte - Missioklinik site, Pneumology and Respiratory Medicine, Würzburg, Germany., Hummel HD; Translational Oncology/Early Clinical Trial Unit, Comprehensive Cancer Centre Mainfranken, University Hospital Wuerzburg, Wuerzburg, Germany., Hegedüs B; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany., Schuler M; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany.; Department of Medical Oncology, West German Cancer Centre Essen, University Duisburg-Essen, Essen, Germany., Plönes T; Department of Medical Oncology, West German Cancer Centre Essen, University Duisburg-Essen, Essen, Germany.; Division of Thoracic Surgery, Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany., Aigner C; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.; Department of Thoracic Surgery, Medical University of Vienna, Vienna General Hospital, Vienna, Austria., Elter T; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany., Toepelt K; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany., Ko YD; Comprehensive Cancer Centre CIO Bonn, Bonn, Germany., Kurz S; Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany., Grohé C; Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany., Serke M; DGD Lungenklinik Hemer, Internal Medicine, Pneumology and Oncology, Hemer, Germany., Höpker K; Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Hagmeyer L; Clinic of Pneumology and Allergology, Centre for Sleep Medicine and Respiratory Care, Bethanien Hospital Solingen, Solingen, Germany., Doerr F; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.; Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany., Hekmath K; Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany., Strapatsas J; Department of Haematology, Oncology and Clinical Immunology, University Hospital of Duesseldorf, Düsseldorf, Germany., Kambartel KO; Krankenhaus Bethanien Moers, Moers, Germany., Chakupurakal G; Praxis für Hämatologie und Onkologie, Koblenz, Germany., Busch A; Medical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany., Bauernfeind FG; Medical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany., Griesinger F; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Luers A; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Dirks W; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Wiewrodt R; Pulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany., Luecke A; Pulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany., Rodermann E; Onkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany., Diel A; Onkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany., Hagen V; Clinic II for Internal Medicine, St.-Johannes-Hospital Dortmund, Dortmund, Germany., Severin K; Haematologie und Onkologie Köln MV-Zentrum, Cologne, Germany., Ullrich RT; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Reinhardt HC; Department of Haematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; West German Cancer Centre, University Hospital Essen, Essen, Germany., Quaas A; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Bogus M; Institute of Legal Medicine, University of Cologne, Cologne, Germany., Courts C; Institute of Legal Medicine, University of Cologne, Cologne, Germany., Nürnberg P; Cologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany., Becker K; Cologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany., Achter V; Computing Centre, University of Cologne, Cologne, Germany., Büttner R; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Wolf J; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Peifer M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. mpeifer@uni-koeln.de.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany. mpeifer@uni-koeln.de., Thomas RK; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. roman.thomas@uni-koeln.de.; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany. roman.thomas@uni-koeln.de.; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany. roman.thomas@uni-koeln.de.

Publikováno v: Nature [Nature] 2024 Mar; Vol. 627 (8005), pp. 880-889. Date of Electronic Publication: 2024 Mar 13.