Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

Autor: Bauer, Lisa, Manganaro, Roberto, Zonsics, Birgit, Hurdiss, Daniel L, Zwaagstra, Marleen, Donselaar, Tim, Welter, Naemi G E, van Kleef, Regina G D M, Lopez, Moira Lorenzo, Bevilacqua, Federica, Raman, Thamidur, Ferla, Salvatore, Bassetto, Marcella, Neyts, Johan, Strating, Jeroen R P M, Westerink, Remco H S, Brancale, Andrea, van Kuppeveld, Frank J M, dI&I I&I-1, Virologie, IRAS OH Toxicology, dIRAS RA-1

Publikováno v: PLoS Biology, 18(11). Public Library of Science
PLoS Biology
PLOS Biology
PLoS Biology, Vol 18, Iss 11, p e3000904 (2020)

There is a great need for antiviral drugs to treat enterovirus (EV) and rhinovirus (RV) infections, which can be severe and occasionally life-threatening. The conserved nonstructural protein 2C, which is an AAA+ ATPase, is a promising target for drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f353d8e22f68e530c8d52bb78dea482
https://dspace.library.uu.nl/handle/1874/409705

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

Autor: Horova, Vladimira, Lyoo, Heyrhyoung, Różycki, Bartosz, Chalupska, Dominika, Smola, Miroslav, Humpolickova, Jana, Strating, Jeroen R. P. M., van Kuppeveld, Frank J. M., Boura, Evzen, Klima, Martin, LS Virologie, dI&I I&I-1

Publikováno v: PLoS Pathogens, Vol 15, Iss 8, p e1007962 (2019)
PLoS Pathogens, 15(8). Public Library of Science
PLoS Pathogens
PLOS Pathogens
'PLoS Pathogens ', vol: 15, pages: e1007962-1-e1007962-28 (2019)
PLoS pathogens 15(8), e1007962-(2019). doi:10.1371/journal.ppat.1007962
PubMed Central

Enteroviruses, members of the family of picornaviruses, are the most common viral infectious agents in humans causing a broad spectrum of diseases ranging from mild respiratory illnesses to life-threatening infections. To efficiently replicate within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6093c28619f8d4a51c090cbc719caa3
https://doaj.org/article/3c595b6221a645c7b30fb60a680283a1

Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles

Autor: van der Schaar, Hilde M, Dorobantu, Cristina M, Albulescu, Lucian, Strating, Jeroen R P M, van Kuppeveld, Frank J M, LS Virologie, dI&I I&I-1

Publikováno v: Trends in Microbiology
Trends in Microbiology, 24(7), 535. Elsevier Limited

All viruses that carry a positive-sense RNA genome (+RNA), such as picornaviruses, hepatitis C virus, dengue virus, and SARS- and MERS-coronavirus, confiscate intracellular membranes of the host cell to generate new compartments (i.e., replication or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623e0cd1aaf768d3539a5c69e9fa0bfb
http://europepmc.org/articles/PMC7126954

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.