Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Stratford, I.J."'
Autor:
Allison, Simon J., Sadiq, Maria, Baronou, Efstathia, Cooper, Patricia A., Dunnill, C., Georgopoulos, N.T., Latif, A., Shepherd, S.L., Shnyder, Steven, Stratford, I.J., Wheelhouse, Richard T., Willans, C., Phillips, Roger M.
Yes
Organometallic complexes offer the prospect of targeting multiple pathways that are important in cancer biology. Here, the preclinical activity and mechanism(s) of action of a silver-bis(N-heterocyclic carbine) complex (Ag8) were evaluated.
Organometallic complexes offer the prospect of targeting multiple pathways that are important in cancer biology. Here, the preclinical activity and mechanism(s) of action of a silver-bis(N-heterocyclic carbine) complex (Ag8) were evaluated.
Externí odkaz:
http://hdl.handle.net/10454/11960
Autor:
Williams, K.J., Albertella, M.R., Fitzpatrick, B., Loadman, Paul, Shnyder, Steven, Chinje, E.C., Telfer, B.A., Dunk, C.R., Harris, P.A., Stratford, I.J.
AQ4N (banoxantrone) is a prodrug that, under hypoxic conditions, is enzymatically converted to a cytotoxic DNA-binding agent, AQ4. Incorporation of AQ4N into conventional chemoradiation protocols therefore targets both oxygenated and hypoxic regions
Externí odkaz:
http://hdl.handle.net/10454/4561
Autor:
Volpato, Milène, Abou-Zeid, N., Tanner, R.W., Glassbrook, L.T., Taylor, James P., Stratford, I.J., Loadman, Paul, Jaffar, M., Phillips, Roger M.
NAD(P)H:quinone oxidoreductase-1 (NQO1) is a potential target for therapeutic intervention but attempts to exploit NQO1 using quinone-based bioreductive prodrugs have been largely compromised by toxicity to organs that inherently express high levels
Externí odkaz:
http://hdl.handle.net/10454/4567
Autor:
Phillips, Roger M., Loadman, Paul, Maitland, Derek J., Shnyder, Steven, Jaffar, M., Steans, Gillian, Cooper, Patricia A., Race, Amanda D., Patterson, A.V., Stratford, I.J.
The indolequinone compound EO9 has good pharmacodynamic properties in terms of bioreductive activation and selectivity for either NAD(P)H:quinone oxidoreductase-1 (NQO1)-rich aerobic or NQO1-deficient hypoxic cells. However, its pharmacokinetic prope
Externí odkaz:
http://hdl.handle.net/10454/3804
Publikováno v:
In Clinical Oncology May 2014 26(5):266-276
Publikováno v:
In European Journal of Cancer March 2004 40(4):503-507
Autor:
Jaffar, M, Everett, S.A, Naylor, M.A, Moore, S.G, Ulhaq, S, Patel, K.B, Stratford, M.R.L, Nolan, J, Wardman, P, Stratford, I.J
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(1):113-118
Akademický článek
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Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(9):2832-2836
Publikováno v:
In European Journal of Cancer July 2016 61 Supplement 1:S197-S197