A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans.

Autor: Caballero-Camino FJ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain., Rodrigues PM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Wångsell F; Albireo AB, Göteborg, Sweden., Agirre-Lizaso A; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain., Olaizola P; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain., Izquierdo-Sanchez L; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain., Perugorria MJ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain., Bujanda L; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain., Angelin B; CardioMetabolic Unit, Department of Medicine and Clinical Department of Endocrinology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Straniero S; CardioMetabolic Unit, Department of Medicine and Clinical Department of Endocrinology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Wallebäck A; Albireo AB, Göteborg, Sweden., Starke I; Albireo AB, Göteborg, Sweden., Gillberg PG; Albireo AB, Göteborg, Sweden., Strängberg E; Albireo AB, Göteborg, Sweden., Bonn B; Albireo AB, Göteborg, Sweden., Mattsson JP; Albireo AB, Göteborg, Sweden., Madsen MR; Gubra, Hoersholm, Denmark., Hansen HH; Gubra, Hoersholm, Denmark., Lindström E; Albireo AB, Göteborg, Sweden., Åkerblad P; Albireo AB, Göteborg, Sweden., Banales JM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, 'Instituto de Salud Carlos III'), Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2023 Sep 01; Vol. 78 (3), pp. 709-726. Date of Electronic Publication: 2023 Apr 01.

Murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

Autor: Straniero, S., Laskar, A., Savva, C., Härdfeldt, J., Angelin, B., Rudling, M.

Publikováno v: In Atherosclerosis August 2021 331:e128-e128

Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism.

Autor: Straniero, S., Angelin, B., Rudling, M., Al‐Khaifi, A., Al-Khaifi, A, Kumar, C., Voronova, V., Chernikova, D., Sokolov, V., Al-Khaifi, Amani, Straniero, Sara, Angelin, Bo, Rudling, Mats, Kumar, Chanchal, Voronova, Veronika, Chernikova, Dina, Sokolov, Victor

Publikováno v: Journal of Internal Medicine; Nov2018, Vol. 284 Issue 5, p546-559, 14p, 1 Diagram, 1 Chart, 4 Graphs

Body Mass Index May be the Strongest Predictor of New-Onset Asymptomatic Gallbladder Stone Disease Risk in the Pre-Initial Overweight Population Without Diagnosed Diabetes: A Case-Control Study.

Autor: Jing Tan¹, Jianqin Zhang², Mao Ma³, Binwu Sheng³ bwsheng@xjtufh.edu.cn

Publikováno v: Current Topics in Nutraceutical Research. Nov2024, Vol. 22 Issue 4, p1177-1186. 10p.

Author Correction: Liver macrophages regulate systemic metabolism through non-inflammatory factors.

Autor: Morgantini C; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Jager J; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.; Université Nice Côte d'Azur, INSERM U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity, Nice, France., Li X; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Levi L; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Azzimato V; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Sulen A; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Barreby E; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Xu C; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Tencerova M; Department of Molecular Endocrinology, KMEB, University of Southern Denmark, Odense University Hospital and Danish Diabetes Academy, Odense, Denmark., Näslund E; Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden., Kumar C; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.; Translational Sciences, Cardiovascular, Renal and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Verdeguer F; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland., Straniero S; Metabolism Unit C2:94, Department of Medicine, and Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Stockholm, Sweden., Hultenby K; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Huddinge, Sweden., Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Ellis E; Division of Transplantation Surgery, CLINTEC, Karolinska Institutet, Huddinge, Sweden., Rydén M; Unit of Endocrinology, Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Kutter C; Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Hurrell T; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden., Lauschke VM; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden., Boucher J; Bioscience, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, Lundberg Laboratory for Diabetes Research, University of Gothenburg, Gothenburg, Sweden., Tomčala A; Laboratory of Evolutionary Protistology, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic., Krejčová G; Faculty of Science, University of South Bohemia, and Institute of Entomology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic., Bajgar A; Faculty of Science, University of South Bohemia, and Institute of Entomology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic., Aouadi M; Integrated Cardio Metabolic Center (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden. myriam.aouadi@ki.se.

Publikováno v: Nature metabolism [Nat Metab] 2021 Feb; Vol. 3 (2), pp. 287.