HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer.

Autor: Ranti D; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yu H; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang YA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bieber C; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Strandgaard T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Salomé B; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Houghton S; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Kim J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Ravichandran H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Okulate I; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Merritt E; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bang S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Demetriou A; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Li Z; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ruan DF; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Daza J; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rai R; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hegewisch-Solloa E; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York NY, USA., Mace EM; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York NY, USA., Fernandez-Rodriguez R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Izadmehr S; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Doherty G; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Narasimhan A; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farkas AM; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cruz-Encarnacion P; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shroff S; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Patel F; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tran M; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Park SJ; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Qi J; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Patel M; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Geanon D; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kelly G; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Real RM; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Miake-Iye S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Angeliadis K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Radkevich E; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Thin TH; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Garcia-Barros M; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Brown H; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Martin B; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Mateo A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Soto A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Sussman R; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Shiwlani S; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Francisco-Simon S; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Beaumont KG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hu Y; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang YC; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sebra RP; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smith S; Center for Inflammation research and Translational Medicine, Brunel University London, London, UK., Skobe M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Clancy-Thompson E; AstraZeneca, Oncology R & D Unit, Gaithersburg, Maryland, USA., Palmer D; AstraZeneca, Oncology R & D Unit, Gaithersburg, Maryland, USA., Hammond S; AstraZeneca, Oncology R & D Unit, Gaithersburg, Maryland, USA., Hopkins BD; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wiklund P; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhu J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bravo-Cordero JJ; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brody R; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Hopkins B; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Inflammation research and Translational Medicine, Brunel University London, London, UK.; AstraZeneca, Oncology R & D Unit, Gaithersburg, Maryland, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Chen Z; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Tocheva A; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhardwaj N; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Galsky MD; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sfakianos JP; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Horowitz A; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.

Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer.

Autor: Strandgaard T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark., Birkenkamp-Demtröder K; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Salminen L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Urology, Turku University Hospital and University of Turku, Turku, Finland., Prip F; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rasmussen J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andreasen TG; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Christensen E; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark., Knudsen M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark., Steiniche T; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus N, Denmark., Jensen JB; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Urology, Aarhus University Hospital, Aarhus N, Denmark., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: lars@clin.au.dk.

Publikováno v: European urology [Eur Urol] 2024 Jan; Vol. 85 (1), pp. 82-92. Date of Electronic Publication: 2023 Sep 16.

Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer.

Autor: Christensen E; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Birkenkamp-Demtröder K; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Elbæk SK; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Taber A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andreasen TG; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Strandgaard T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Knudsen M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Agerbæk M; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Jensen JB; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Apr 14; Vol. 29 (8), pp. 1582-1591.

Elevated T-cell Exhaustion and Urinary Tumor DNA Levels Are Associated with Bacillus Calmette-Guérin Failure in Patients with Non-muscle-invasive Bladder Cancer.

Autor: Strandgaard T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Christensen E; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Birkenkamp-Demtröder K; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andreasen TG; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Kjær A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ranti D; Department of Oncological Sciences, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Wang YA; Department of Oncological Sciences, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Bieber C; Department of Oncological Sciences, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Prip F; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rasmussen J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Steiniche T; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Birkbak N; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Sfakianos J; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Horowitz A; Department of Oncological Sciences, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jensen JB; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: lars@clin.au.dk.

Publikováno v: European urology [Eur Urol] 2022 Dec; Vol. 82 (6), pp. 646-656. Date of Electronic Publication: 2022 Oct 07.

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.

Autor: Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Prip F; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark., Taber A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Groeneveld CS; Cartes d'Identité des Tumeurs (CIT) Program, Ligue Nationale Contre le Cancer, Paris, France.; Oncologie Moleculaire, UMR144, Institut Curie, Paris, France., Birkenkamp-Demtröder K; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Jensen JB; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Urology, Aarhus University Hospital, Aarhus N, Denmark., Strandgaard T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark., Christensen E; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Sokac M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Birkbak NJ; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Maretty L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Hermann GG; Department of Urology, Herlev hospital, Copenhagen University, Copenhagen, Denmark., Petersen AC; Department of Pathology, Aalborg University Hospital, Aalborg, Denmark., Weyerer V; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Grimm MO; Department of Urology, Jena University Hospital, Jena, Germany., Horstmann M; Department of Urology, Jena University Hospital, Jena, Germany.; Department of Urology, Malteser Hospital St. Josephshospital, Krefeld Uerdingen, Krefeld, Germany., Sjödahl G; Division of Urological Research, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden., Höglund M; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden., Steiniche T; Department of Pathology, Aarhus University Hospital, Aarhus N, Denmark., Mogensen K; Department of Urology, Herlev hospital, Copenhagen University, Copenhagen, Denmark., de Reyniès A; Cartes d'Identité des Tumeurs (CIT) Program, Ligue Nationale Contre le Cancer, Paris, France., Nawroth R; Department of Urology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Jordan B; Departments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of Medicine, Chicago, IL, USA., Lin X; Departments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of Medicine, Chicago, IL, USA., Dragicevic D; Clinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Ward DG; Bladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK., Goel A; Bladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK., Hurst CD; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Raman JD; Department of Surgery, Division of Urology, Pennsylvania State University, Hershey, PA, USA., Warrick JI; Department of Pathology and Laboratory Medicine, Division of Urology, Department of Biochemistry and Molecular Biology, Pennsylvania State University, Hershey, PA, USA., Segersten U; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Sikic D; Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., van Kessel KEM; Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Maurer T; Department of Urology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.; Department of Urology and Martini-Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meeks JJ; Departments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of Medicine, Chicago, IL, USA., DeGraff DJ; 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Publikováno v: Nature communications [Nat Commun] 2021 Apr 16; Vol. 12 (1), pp. 2301. Date of Electronic Publication: 2021 Apr 16.