Zobrazeno 1 - 10
of 591
pro vyhledávání: '"Strand invasion"'
Akademický článek
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Publikováno v:
Animal Bioscience
Animal Bioscience, Vol 35, Iss 1, Pp 126-137 (2022)
Animal Bioscience, Vol 35, Iss 1, Pp 126-137 (2022)
Objective: Efficient gene editing technology is critical for successful knock-in in domestic animals. RAD51 recombinase (RAD51) gene plays an important role in strand invasion during homologous recombination (HR) in mammals, and is regulated by check
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abca04b614944a7f674d1238e5cbf61f
https://doi.org/10.5713/ab.21.0117
https://doi.org/10.5713/ab.21.0117
Publikováno v:
Molecules; Volume 28; Issue 1; Pages: 127
The development of chemically modified oligonucleotides enabling robust, sequence-unrestricted recognition of complementary chromosomal DNA regions has been an aspirational goal for scientists for many decades. While several groove-binding or strand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e109fbc222eb9e896d80495c823319d0
Publikováno v:
Journal of Animal Reproduction and Biotechnology, Vol 36, Iss 3, Pp 121-128 (2021)
Increasing the efficiency of HR (homologous recombination) is important for a successful knock-in. Rad51 is mainly involved in homologous recombination and is associated with strand invasion. The HR-related mismatch repair system maintains HR fidelit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5144fbf330392e795774f30715c2158b
https://doi.org/10.12750/jarb.36.3.121
https://doi.org/10.12750/jarb.36.3.121
Akademický článek
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Autor:
Alexander Carver, Xiaodong Zhang
Publikováno v:
Seminars in Cell & Developmental Biology. 113:3-13
Rad51 recombinase is the central player in homologous recombination, the faithful repair pathway for double-strand breaks and key event during meiosis. Rad51 forms nucleoprotein filaments on single-stranded DNA, exposed by a double-strand break. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013d1a95130b25ed485a7f3e4ac77146
https://doi.org/10.1016/j.semcdb.2020.06.012
https://doi.org/10.1016/j.semcdb.2020.06.012
Autor:
Alan Ann Lerk Ong, Jiazi Tan, Malini Bhadra, Clément Dezanet, Kiran M. Patil, Mei Sian Chong, Ryszard Kierzek, Jean-Luc Decout, Xavier Roca, Gang Chen
Publikováno v:
Molecules, Vol 24, Iss 16, p 3020 (2019)
Alternative splicing of tau pre-mRNA is regulated by a 5′ splice site (5′ss) hairpin present at the exon 10−intron 10 junction. Single mutations within the hairpin sequence alter hairpin structural stability and/or the binding of splicing facto
Externí odkaz:
https://doaj.org/article/62372f15fb0e42168603057572ef14e1
Publikováno v:
Zhang, X, Li, G, Chen, G, Zhu, N, Wu, D, Wu, Y & James, T D 2021, ' Recent progresses and remaining challenges for the detection of Zika virus ', Medicinal Research Reviews, vol. 41, no. 4, pp. 2039-2108 . https://doi.org/10.1002/med.21786
Zika virus (ZIKV) has emerged as a particularly notorious mosquito-borne flavivirus, which can lead to a devastating congenital syndrome in the fetuses of pregnant mothers (e.g., microcephaly, spasticity, craniofacial disproportion, miscarriage, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc517cb375490cd1caf02c6d9076c50e
https://doi.org/10.1002/med.21786
https://doi.org/10.1002/med.21786
Publikováno v:
Nucleic Acids Research
As an effective programmable DNA targeting tool, CRISPR–Cas9 system has been adopted in varieties of biotechnological applications. However, the off-target effects, derived from the tolerance towards guide-target mismatches, are regarded as the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95c8fc5a44286d3e40d00272ddec1ca
https://doi.org/10.1093/nar/gkaa1295
https://doi.org/10.1093/nar/gkaa1295
Publikováno v:
Chemical Science
Introduction of artificial metal–ligand base pairs can enrich the structural diversity and functional controllability of nucleic acids. In this work, we revealed a novel approach by placing a ligand-type nucleoside as an independent toehold to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a927f0a6d126796f7aa3513ee441ae2
https://doi.org/10.1039/d1sc01041g
https://doi.org/10.1039/d1sc01041g