Histone H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation.

Autor: Fox GC; Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Poncha KF; Verna & Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas, USA., Smith BR; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., van der Maas LN; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Robbins NN; EpiCypher, Inc, Durham, North Carolina, USA., Graham B; EpiCypher, Inc, Durham, North Carolina, USA., Dowen JM; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Strahl BD; Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: brian_strahl@med.unc.edu., Young NL; Verna & Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas, USA. Electronic address: nicolas.young@bcm.edu., Jain K; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: kjain@umn.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Aug; Vol. 300 (8), pp. 107527. Date of Electronic Publication: 2024 Jul 01.

Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.

Autor: Nguyen MC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Rostamian H; Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.; Curriculum in Genetics and Molecular Biology, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA., Raman A; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Wei P; Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.; Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, 530004, China., Becht DC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Erbse AH; Department of Biochemistry, University of Colorado, Boulder, CO, 80303, USA., Klein BJ; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Gilbert TM; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Zhang G; Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA., Blanco MA; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, USA., Strahl BD; Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA., Taverna SD; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA., Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. tatiana.kutateladze@cuanschutz.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 24; Vol. 15 (1), pp. 5335. Date of Electronic Publication: 2024 Jun 24.

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment.

Autor: Daugird TA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shi Y; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill, NC, USA., Holland KL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147, USA., Rostamian H; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Liu Z; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147, USA., Lavis LD; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147, USA., Rodriguez J; National Institute of Environmental Health Sciences, Durham, NC, 27709, USA., Strahl BD; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Legant WR; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. legantw@email.unc.edu.; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill, NC, USA. legantw@email.unc.edu.

Publikováno v: Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4178. Date of Electronic Publication: 2024 May 16.

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Autor: Muneer A; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wang L; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xie L; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhang F; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Wu B; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mei L; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lenarcic EM; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Feng EH; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Song J; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xiong Y; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yu X; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wang C; Center for Genomics, Division of Microbiology & Molecular Genetics, Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92350, USA., Jain K; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Strahl BD; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cook JG; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wan YY; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Moorman NJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chen X; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: xianc@email.unc.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2023 Dec 21; Vol. 30 (12), pp. 1525-1541.e7. Date of Electronic Publication: 2023 Oct 19.

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

Autor: Zhao S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Lu J; Department of Biochemistry, University of California, Riverside, CA, USA., Pan B; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Fan H; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; The First Affiliated Hospital of Harbin Medical University, Harbin, P. R. China., Byrum SD; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Xu C; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Kim A; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Guo Y; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kanchi KL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Gong W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Sun T; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA., Storey AJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Burkholder NT; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Mackintosh SG; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Kuhlers PC; Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Edmondson RD; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Strahl BD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Diao Y; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA., Tackett AJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Raab JR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Cai L; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Song J; Department of Biochemistry, University of California, Riverside, CA, USA. jikui.song@ucr.edu., Wang GG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. greg.wang@duke.edu.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA. greg.wang@duke.edu.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA. greg.wang@duke.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg.wang@duke.edu.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. greg.wang@duke.edu.

Publikováno v: Nature [Nature] 2023 Nov; Vol. 623 (7987), pp. 633-642. Date of Electronic Publication: 2023 Nov 08.