Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP.

Autor: Strack PR; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Brodie EJ; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.; CSL Behring, Broadmeadows, VIC, 3047, Australia., Zhan H; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Schuenemann VJ; Department of Protein Evolution, Max-Planck-Institute for Developmental Biology, Tübingen, 72076, Germany.; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland., Valente LJ; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Saiyed T; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Lowth BR; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia., Angley LM; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Perugini MA; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Zeth K; Department of Protein Evolution, Max-Planck-Institute for Developmental Biology, Tübingen, 72076, Germany.; Department of Science and Environment, Roskilde University, DK-4000, Roskilde, Denmark., Truscott KN; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. k.truscott@latrobe.edu.au., Dougan DA; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. d.dougan@latrobe.edu.au.

Publikováno v: Communications biology [Commun Biol] 2020 Nov 06; Vol. 3 (1), pp. 646. Date of Electronic Publication: 2020 Nov 06.

An accessible pharmacodynamic transcriptional biomarker for notch target engagement.

Autor: Tanis, KQ, Podtelezhnikov, AA, Blackman, SC, Hing, J, Railkar, RA, Lunceford, J, Klappenbach, JA, Wei, B, Harman, A, Camargo, LM, Shah, S, Finney, EM, Hardwick, JS, Loboda, A, Watters, J, Bergstrom, DA, Demuth, T, Herman, GA, Strack, PR, Iannone, R

Publikováno v: Clinical Pharmacology & Therapeutics; Apr2016, Vol. 99 Issue 4, p370-380, 11p

Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells.

Autor: Yun J; Cardinal Bernardin Cancer Center and Department of Pathology, Loyola University Chicago, Maywood, IL, USA., Pannuti A, Espinoza I, Zhu H, Hicks C, Zhu X, Caskey M, Rizzo P, D'Souza G, Backus K, Denning MF, Coon J, Sun M, Bresnick EH, Osipo C, Wu J, Strack PR, Tonetti DA, Miele L

Publikováno v: Oncogenesis [Oncogenesis] 2013 Aug 05; Vol. 2, pp. e60. Date of Electronic Publication: 2013 Aug 05.

Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.

Autor: Grudzien P; Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA., Lo S, Albain KS, Robinson P, Rajan P, Strack PR, Golde TE, Miele L, Foreman KE

Publikováno v: Anticancer research [Anticancer Res] 2010 Oct; Vol. 30 (10), pp. 3853-67.

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

Autor: Efferson CL; Department of Oncology, Pharmacology, Laboratory of Animal Research, Merck Research Laboratories, Boston, Massachusetts 02115, USA., Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK

Publikováno v: Cancer research [Cancer Res] 2010 Mar 15; Vol. 70 (6), pp. 2476-84. Date of Electronic Publication: 2010 Mar 02.