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Critical transitions in pancreatic islets

Autor: Korošak, Dean, Postić, Sandra, Stožer, Andraž, Podobnik, Boris, Rupnik, Marjan Slak

Calcium signals in pancreatic beta-cells collectives show a sharp transition from uncorrelated to correlated state resembling a phase transition as the slowly increasing glucose concentration crosses the tipping point. However, the exact nature or th

Externí odkaz: http://arxiv.org/abs/2410.17756

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Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model perspective

Autor: Šterk, Marko, Barać, Uroš, Stožer, Andraž, Gosak, Marko

Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory activity manifests itself on multiple timescales and consists of bursting electrical activity, subsequent

Externí odkaz: http://arxiv.org/abs/2304.13961

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Collective biological computation of metabolic economy

Autor: Korošak, Dean, Stožer, Andraž, Rupnik, Marjan Slak

Presented with sensory challenges, living cells employ extensive noisy, fluctuating signalling and communication among themselves to compute a physiologically proper response which often results in symmetry breaking. We propose, based on the results

Externí odkaz: http://arxiv.org/abs/2206.07787

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Autopoietic influence hierarchies in pancreatic $\beta$-cells

Autor: Korošak, Dean, Jusup, Marko, Podobnik, Boris, Stožer, Andraž, Dolenšek, Jurij, Holme, Petter, Rupnik, Marjan Slak

Publikováno v: Phys. Rev. Lett. 127, 168101, 2021

$\beta$-cells are biologically essential for humans and other vertebrates. Because their functionality arises from cell-cell interactions, they are also a model system for collective organization among cells. There are currently two contradictory pic

Externí odkaz: http://arxiv.org/abs/2101.02255

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