Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stoyan N. Angelov"'
Autor:
Shreyas A. Bhave, Dongchuan Guo, Stoyan N. Angelov, Michael J. Bamshad, Deborah A. Nickerson, Dianna M. Milewicz, Mary C. Wallingford
Publikováno v:
Cardiogenetics, Vol 11, Iss 3, Pp 132-138 (2021)
Thoracic aortic aneurysms (TAAs) that progress to acute thoracic aortic dissections (TADs) are life-threatening vascular events that have been associated with altered transforming growth factor (TGF) β signaling. In addition to TAA, multiple genetic
Externí odkaz:
https://doaj.org/article/ef8c115c55394e3996e080037497968e
Autor:
Hao Wei, Jie Hong Hu, Stoyan N. Angelov, Kate Fox, James Yan, Rachel Enstrom, Alexandra Smith, David A. Dichek
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 1 (2017)
BackgroundMarfan syndrome (MFS) is caused by mutations in the gene encoding fibrillin‐1 (FBN1); however, the mechanisms through which fibrillin‐1 deficiency causes MFS‐associated aortopathy are uncertain. Recently, attention was focused on the
Externí odkaz:
https://doaj.org/article/8bcff69578404b68bce0efd4f35d5ec6
Autor:
Chloe Y. Lee, Stoyan N. Angelov, Jay Zhu, Lianxiang Bi, Nicole Sanford, Ilkay Alp Yildirim, David A. Dichek
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:764-771
Background: To test the hypothesis that smooth muscle cell (SMC) TGF-β (transforming growth factor beta) signaling contributes to maintenance of aortic structure and function beyond the early postnatal period. Methods: We deleted the TBR2 (type 2 TG
Autor:
Dong-chuan Guo, Mary C. Wallingford, Michael J. Bamshad, Shreyas A. Bhave, Dianna M. Milewicz, Stoyan N. Angelov, Deborah A. Nickerson
Publikováno v:
Cardiogenetics, Vol 11, Iss 15, Pp 132-138 (2021)
Cardiogenetics
Cardiogenetics
Thoracic aortic aneurysms (TAAs) that progress to acute thoracic aortic dissections (TADs) are life-threatening vascular events that have been associated with altered transforming growth factor (TGF) β signaling. In addition to TAA, multiple genetic
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background: Altered transforming growth factor beta (TGF-β) signaling in aortic SMC is implicated as a cause of aortic aneurysms and dissections (AAD), with AAD attributed both to increased and decreased TGF-β signaling. Loss of TGF-β signaling in
Autor:
Francis Kim, Mark W. Majesky, Hao Wei, David A. Dichek, Jay Zhu, Ilkay Alp Yildirim, Frank V. Brozovich, Stoyan N. Angelov, Jie Hong Hu
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Humans and mice with loss-of-function variants of genes in the TGF-β (transforming growth factor beta) signaling pathway develop aortic aneurysms. These aneurysms could be caused by decreased aortic smooth muscle cell (SMC) contractile-pr
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37:2102-2113
Objective— The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that systemic blockade of TGF-β by neutralizing antibodies accelerated AAA development in angiot
Autor:
James Yan, Alexandra Smith, Kate Fox, Julie K. Allen, Thomas N. Wight, Hao Wei, Inkyung Kang, David A. Dichek, Jie Hong Hu, Stoyan N. Angelov, Liang Du, Nathan Airhart, Rachel Enstrom, Mia Jaffe
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:2647-2656
Objective— Prenatal deletion of the type II transforming growth factor-β (TGF-β) receptor (TBRII) prevents normal vascular morphogenesis and smooth muscle cell (SMC) differentiation, causing embryonic death. The role of TBRII in adult SMC is less
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Introduction: Tgfbr2 G357W/+ mice have a loss-of-function Tgfbr2 allele ( G357W ) that is orthologous to an allele found in humans with Loeys-Dietz syndrome (LDS). Tgfbr2 G357W/+ mice have kyphosis, aortic dilation and elongation, and die suddenly fr
Human abdominal aortic aneurysm (AAA) is typically defined as an enlargement of the luminal diameter of the abdominal aorta by >50% or to a diameter >3 cm.1,2 Virtually, all AAA are clinically silent and are detected either during radiological invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86151f6dcc9402136e1fdf3f2eb3884e
https://europepmc.org/articles/PMC5687298/
https://europepmc.org/articles/PMC5687298/