The Efficiency of In Vitro Differentiation of Primate iPSCs into Cardiomyocytes Depending on Their Cell Seeding Density and Cell Line Specificity

Autor: Yuliia Tereshchenko, Stoyan G. Petkov, Rüdiger Behr

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 15, p 8449 (2024)

A thorough characterization of induced pluripotent stem cells (iPSCs) used with in vitro models or therapeutics is essential. Even iPSCs derived from a single donor can exhibit variability within and between cell lines, which can lead to heterogeneit

Externí odkaz: https://doaj.org/article/5a77547595b4412986af675662249ff7

Stem cells: Perspectives for the pig in relation to other species

Autor: Stoyan G. Petkov

Publikováno v: Bioscientifica Proceedings.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c74737b7f7057c93a6eee6340215d219
https://doi.org/10.1530/biosciprocs.19.0027

Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties

Autor: Anna Buermann, Reinhard Schwinzer, Rabea Hein, Stoyan G. Petkov, Wiebke Baars, Antje Brinkmann, Heiner Niemann, Andrea Lucas-Hahn, Björn Petersen

Publikováno v: Xenotransplantation. 25(5)

Background The programmed cell death-1 (PD-1, CD279)/PD-Ligand1 (PD-L1, CD274) receptor system is crucial for controlling the balance between immune activation and induction of tolerance via generation of inhibitory signals. Expression of PD-L1 is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640f53ea1f12e73f8503ce79ef02ed82
https://pubmed.ncbi.nlm.nih.gov/29446180

Evaluation of porcine stem cells competence for somatic cell nuclear transfer and production of cloned animals

Autor: Jacob F. Bentzon, Charlotte Brandt Sørensen, Jan O. Secher, Yonglun Luo, Henrik Callesen, Ying Liu, Mette Schmidt, Stoyan G. Petkov, Dong Li, Kristine K. Freude, Vanessa Jane Hall, Poul Hyttel

Publikováno v: Secher, J, Liu, Y, Petkov, S, Luo, Y, Li, D, Hall, V J, Schmidt, M, Callesen, H, Bentzon, J F, Sørensen, C B, Freude, K K & Hyttel, P 2017, ' Evaluation of porcine stem cells competence for somatic cell nuclear transfer and production of cloned animals ', Animal Reproduction Science, vol. 178, pp. 40-49 . https://doi.org/10.1016/j.anireprosci.2017.01.007

Porcine somatic cell nuclear transfer (SCNT) has been used extensively to create genetically modified pigs, but the efficiency of the methodology is still low. It has been hypothesized that pluripotent or multipotent stem cells might result in increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82655d11d2b48f2a62ea005614effbd0
https://pure.au.dk/portal/da/publications/evaluation-of-porcine-stem-cells-competence-for-somatic-cell-nuclear-transfer-and-production-of-cloned-animals(80f11a98-9a07-4920-91b2-1e242f33f6f5).html

In vitro culture and characterization of putative porcine embryonic germ cells derived from domestic breeds and Yucatan mini pig embryos at Days 20–24 of gestation

Autor: Stoyan G. Petkov, Hendrik Marks, Tino Klein, Rodrigo S. Garcia, Poul Hyttel, Henk Stunnenberg, Yu Gao

Publikováno v: Stem Cell Research
Stem Cell Research; Vol 6
Stem Cell Research, 6, 226-237
Stem Cell Research, 6, 3, pp. 226-237

Embryonic germ cells (EGC) are cultured pluripotent cells derived from primordial germ cells (PGC). This study explored the possibility of establishing porcine EGC from domestic breeds and Yucatan mini pigs using embryos at Days 17-24 of gestation. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d2b033e0fc8e776c8d6ad5d75a3dc5
https://doi.org/10.1016/j.scr.2011.01.003