Zobrazeno 1 - 10
of 663
pro vyhledávání: '"Stourac P."'
Autor:
Opálený, Filip, Ulbrich, Pavol, Planas-Iglesias, Joan, Byška, Jan, Štourač, Jan, Bednář, David, Furmanová, Katarína, Kozlíková, Barbora
In understanding and redesigning the function of proteins in modern biochemistry, protein engineers are increasingly focusing on exploring regions in proteins called loops. Analyzing various characteristics of these regions helps the experts design t
Externí odkaz:
http://arxiv.org/abs/2407.20054
Autor:
Katerina Slaba, Petra Pokorna, Robin Jugas, Hana Palova, Dagmar Prochazkova, Stefania Aulicka, Klara Spanelova, Pavlina Danhofer, Ondrej Horak, Jana Tuckova, Petra Kleiblova, Renata Gaillyova, Matej Hrunka, Martin Jouza, Blanka Pinkova, Jan Papez, Petra Konecna, Jana Zidkova, Petr Stourac, Jaroslav Sterba, Regina Demlova, Eva Demlova, Petr Jabandziev, Ondrej Slaby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In the last decade, undiagnosed disease programs have emerged to address the significant number of individuals with suspected but undiagnosed rare genetic diseases. In our single-center study, we have launched a pilot program for pediatric p
Externí odkaz:
https://doaj.org/article/5632c7178ab1493c9496854f9b2ecf9d
Autor:
O. Vavra, J. Tyzack, F. Haddadi, J. Stourac, J. Damborsky, S. Mazurenko, J. M. Thornton, D. Bednar
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Tunnels in enzymes with buried active sites are key structural features allowing the entry of substrates and the release of products, thus contributing to the catalytic efficiency. Targeting the bottlenecks of protein tunnels is also a power
Externí odkaz:
https://doaj.org/article/20fa0a24595e4051a8dec4e89a0250d6
Autor:
Dominika Stastna, Jiri Drahota, Michal Lauer, Aneta Mazouchova, Ingrid Menkyova, Jana Adamkova, Radek Ampapa, Michal Dufek, Marketa Grunermelova, Pavel Hradilek, Eva Kubala Havrdova, Jan Mares, Alena Martinkova, Zbysek Pavelek, Marek Peterka, Eva Recmanova, Petra Rockova, Ivana Stetkarova, Pavel Stourac, Marta Vachova, Dana Horakova
Publikováno v:
Biomedical Papers, Vol 168, Iss 3, Pp 262-270 (2024)
Aims. Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, we describe the actual da
Externí odkaz:
https://doaj.org/article/031942c91d96488a818590beaafcebd7
Autor:
Jabandziev Petr, Hubacek Jaroslav Alois, Michalek Jaroslav, Jouza Martin, Papez Jan, Pecl Jakub, Slaba Katerina, Slaby Ondrej, Urik Milan, Aulicka Stefania, Kunovsky Lumir, Dominik Petr, Kratochvil Milan, Klucka Jozef, Stourac Petr
Publikováno v:
Romanian Journal of Internal Medicine, Vol 62, Iss 3, Pp 279-285 (2024)
Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a varia
Externí odkaz:
https://doaj.org/article/b7b44aafc8854c1b9690e272645d972f
Autor:
Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Ihor Arefiev, Joan Planas-Iglesias, Adam Dobias, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Ondrej Slaby, Jiri Damborsky, Stanislav Mazurenko, David Bednar
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individua
Externí odkaz:
https://doaj.org/article/138a77a9475c4a66973983bff91f0986
Autor:
Pavel Potuznik, Jiri Drahota, Dana Horakova, Marek Peterka, Aneta Mazouchova, David Matyas, Zbysek Pavelek, Marta Vachova, Eva Recmanova, Ivana Stetkarova, Jana Libertinova, Jan Mares, Pavel Stourac, Marketa Grunermelova, Alena Martinkova, Jana Adamkova, Pavel Hradilek, Radek Ampapa, Michal Dufek, Eva Kubala Havrdova, Dominika Stastna
Publikováno v:
Journal of Central Nervous System Disease, Vol 16 (2024)
Background Cladribine, a selective immune reconstitution therapy, is approved for the treatment of adult patients with highly active multiple sclerosis (MS). Objectives Provide experience with cladribine therapy in a real-world setting. Methods This
Externí odkaz:
https://doaj.org/article/184f4c6999bb4bada8b072f3e0cb99d2
Autor:
Tamara Skrisovska, Jana Djakow, Petr Jabandziev, Tereza Kramplova, Jozef Klucka, Martina Kosinova, Petr Stourac
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThis simulation-based study aimed to evaluate the efficacy of ventilation during paediatric cardiopulmonary resuscitation (CPR) provided by healthcare professionals (HCPs) and lay rescuers (LRs). The objective was to assess the number of
Externí odkaz:
https://doaj.org/article/e7d7d1b8a93d4feba2cba5112b67bc87
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Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-6 (2022)
Abstract Background Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum d
Externí odkaz:
https://doaj.org/article/3baf940403814884a824c417483dfbe7