Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.

Autor: Kasper MA; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.; Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany., Stengl A; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Ochtrop P; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany., Gerlach M; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Stoschek T; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Schumacher D; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.; Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Helma J; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Penkert M; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.; Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany., Krause E; Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany., Leonhardt H; Department of Biology II, and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Großhadenerstr. 2, 82152, Martinsried, Germany., Hackenberger CPR; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.; Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Aug 19; Vol. 58 (34), pp. 11631-11636. Date of Electronic Publication: 2019 Jul 18.

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Autor: Schumacher D; Department of Chemical-Biology , Leibniz-Institut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10 , 13125 Berlin , Germany . Email: hackenbe@fmp-berlin.de.; Department of Chemistry , Humboldt Universität zu Berlin , Brook-Taylor-Strasse 2 , 12489 Berlin , Germany., Lemke O; Department of Biology, Chemistry, Pharmacy , Freie Universität Berlin , Takustr. 3 , 14195 Berlin , Germany . Email: bettina.keller@fu-berlin.de., Helma J; Department of Biology II , Ludwig Maximilians Universität München and Center for Integrated Protein Science Munich , Großhadenerstr. 2 , 82152 Martinsried , Germany., Gerszonowicz L; Department of Chemistry , Humboldt Universität zu Berlin , Brook-Taylor-Strasse 2 , 12489 Berlin , Germany., Waller V; Department of Biology II , Ludwig Maximilians Universität München and Center for Integrated Protein Science Munich , Großhadenerstr. 2 , 82152 Martinsried , Germany., Stoschek T; Department of Biology II , Ludwig Maximilians Universität München and Center for Integrated Protein Science Munich , Großhadenerstr. 2 , 82152 Martinsried , Germany., Durkin PM; Department of Chemistry , TU Berlin , Müller-Breslau-Str. 10 , 10623 Berlin , Germany., Budisa N; Department of Chemistry , TU Berlin , Müller-Breslau-Str. 10 , 10623 Berlin , Germany., Leonhardt H; Department of Biology II , Ludwig Maximilians Universität München and Center for Integrated Protein Science Munich , Großhadenerstr. 2 , 82152 Martinsried , Germany., Keller BG; Department of Biology, Chemistry, Pharmacy , Freie Universität Berlin , Takustr. 3 , 14195 Berlin , Germany . Email: bettina.keller@fu-berlin.de., Hackenberger CPR; Department of Chemical-Biology , Leibniz-Institut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10 , 13125 Berlin , Germany . Email: hackenbe@fmp-berlin.de.; Department of Chemistry , Humboldt Universität zu Berlin , Brook-Taylor-Strasse 2 , 12489 Berlin , Germany.

Publikováno v: Chemical science [Chem Sci] 2017 May 01; Vol. 8 (5), pp. 3471-3478. Date of Electronic Publication: 2017 Mar 20.

Efficacy and safety of antibody-drug conjugates in the treatment of urothelial cell carcinoma: a systematic review and meta-analysis of prospective clinical trials.

Autor: Jun-Wei Ren, Ze-Yu Chen, Yun-Jin Bai, Ping Han

Publikováno v: Frontiers in Pharmacology; 2024, p1-15, 15p

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Multiple paedomorphic lineages of soft-substrate burrowing invertebrates: parallels in the origin of Xenocratena and Xenoturbella.

Autor: Martynov, Alexander¹ (AUTHOR) martynov@zmmu.msu.ru, Lundin, Kennet^2,3 (AUTHOR), Picton, Bernard^4,5 (AUTHOR), Fletcher, Karin⁶ (AUTHOR), Malmberg, Klas^3,7 (AUTHOR), Korshunova, Tatiana^1,8 (AUTHOR)

Publikováno v: PLoS ONE. 1/15/2020, Vol. 15 Issue 1, p1-24. 24p.