Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering.

Autor: Lamothe RC; Metagenomi, Inc., Emeryville, California, USA., Storlie MD; Metagenomi, Inc., Emeryville, California, USA., Espinosa DA; Metagenomi, Inc., Emeryville, California, USA., Rudlaff R; Metagenomi, Inc., Emeryville, California, USA., Browne P; Metagenomi, Inc., Emeryville, California, USA., Liu J; Metagenomi, Inc., Emeryville, California, USA., Rivas A; Metagenomi, Inc., Emeryville, California, USA., Devoto A; Metagenomi, Inc., Emeryville, California, USA., Oki J; Metagenomi, Inc., Emeryville, California, USA., Khoubyari A; Metagenomi, Inc., Emeryville, California, USA., Goltsman DSA; Metagenomi, Inc., Emeryville, California, USA., Lin JL; Metagenomi, Inc., Emeryville, California, USA., Butterfield CN; Metagenomi, Inc., Emeryville, California, USA., Brown CT; Metagenomi, Inc., Emeryville, California, USA., Thomas BC; Metagenomi, Inc., Emeryville, California, USA., Cost GJ; Metagenomi, Inc., Emeryville, California, USA.

Publikováno v: The CRISPR journal [CRISPR J] 2023 Jun; Vol. 6 (3), pp. 243-260. Date of Electronic Publication: 2023 May 23.

Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.

Autor: Pennell CA; Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: penne001@umn.edu., Barnum JL; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., McDonald-Hyman CS; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Panoskaltsis-Mortari A; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Riddle MJ; Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Xiong Z; Division of Hematology and Oncology, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Loschi M; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Thangavelu G; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Campbell HM; Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA., Storlie MD; Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA., Refaeli Y; Department of Dermatology, University of Colorado, Aurora, CO 80045, USA., Furlan SN; Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Ben Towne Center for Childhood Cancer, The Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98101, USA., Jensen MC; Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Ben Towne Center for Childhood Cancer, The Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98101, USA., Kean LS; Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Ben Towne Center for Childhood Cancer, The Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98101, USA., Miller JS; Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Tolar J; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Osborn MJ; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2018 Jun 06; Vol. 26 (6), pp. 1423-1434. Date of Electronic Publication: 2018 Apr 07.