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The predictive validity of the drug-naive bilaterally MPTP-treated monkey as a model of Parkinson's disease:effects of L-DOPA and the D1 agonist SKF 82958

Autor: Andringa, G, Lubbers, L, Drukarch, B, Stoof, J C, Cools, A R

Publikováno v: Andringa, G, Lubbers, L, Drukarch, B, Stoof, J C & Cools, A R 1999, ' The predictive validity of the drug-naive bilaterally MPTP-treated monkey as a model of Parkinson's disease : effects of L-DOPA and the D1 agonist SKF 82958 ', Behavioural pharmacology, vol. 10, no. 2, pp. 175-82 .

The aim of this study was twofold: (1) to study the predictive validity of the drug-naive, bilaterally MPTP-treated monkey as an animal model of Parkinson's disease (PD), and (2) to investigate the therapeutic and undesired effects of the D1 agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::def992398ba7c628cd4f967ec6b78c27
https://research.vumc.nl/en/publications/ae30f09e-b727-48a8-89c0-38eb7b0de87b

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Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist

Autor: van de Witte, S V, Drukarch, B, Stoof, J C, Voorn, P

Publikováno v: Experimental Brain Research, 61(1-2), 219-23. Springer Verlag
van de Witte, S V, Drukarch, B, Stoof, J C & Voorn, P 1998, ' Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist ', Experimental Brain Research, vol. 61, no. 1-2, pp. 219-23 .

In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with l-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-383

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a991365c9a766fddc6ea2f1711e6ca8d
https://research.vumc.nl/en/publications/b4f64c0d-b1bb-45cd-adc6-4838f1353fb3

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Iodine-123-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iod ophenyl)tropane SPECT in healthy controls and early-stage, drug-naive Parkinson's disease

Autor: Tissingh, G., Booij, J., Bergmans, P., Winogrodzka, A., Janssen, A. G., van Royen, E. A., Stoof, J. C., Wolters, E. C.

Publikováno v: Journal of nuclear medicine, 39(7), 1143-1148. Society of Nuclear Medicine Inc.

The aims of this study were to investigate whether the loss of striatal dopamine transporters in early and drug-naive patients with Parkinson's disease could be demonstrated by means of 123I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodoph eny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::6f7b9ff180b852c655b0d135e0870bd1
https://pure.amc.nl/en/publications/iodine123nomegafluoropropyl2betacarbomethoxy3beta4iod-ophenyltropane-spect-in-healthy-controls-and-earlystage-drugnaive-parkinsons-disease(695c839e-5b6e-4b95-ad9d-1fa1f6e5939e).html

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Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-CIT SPECT

Autor: Tissingh, G., Bergmans, P., Booij, J., Winogrodzka, A., van Royen, E. A., Stoof, J. C., Wolters, E. C.

Publikováno v: Journal of neurology, 245(1), 14-20. D. Steinkopff-Verlag

Ten healthy subjects and 16 patients with early Parkinson's disease (PD) were examined with single photon emission computed tomography (SPECT) and [123I]beta-CIT, a ligand for the dopamine (DA) transporter. Only drug-naive patients were examined sinc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::6681627c3c3b4f6c6d143cfd21d79c4e
https://pure.amc.nl/en/publications/drugnaive-patients-with-parkinsons-disease-in-hoehn-and-yahr-stages-i-and-ii-show-a-bilateral-decrease-in-striatal-dopamine-transporters-as-revealed-by-123ibetacit-spect(b9a72e5c-8c29-416c-8ba3-e9a0b07c1df7).html

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Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease

Autor: Booij, J., Habraken, J. B., Bergmans, P., Tissingh, G., Winogrodzka, A., Wolters, E. C., Janssen, A. G., Stoof, J. C., van Royen, E. A.

Publikováno v: Journal of nuclear medicine, 39(11), 1879-1884. Society of Nuclear Medicine Inc.

Several SPECT studies reported decreased striatal 123I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodoph enyl)nortropane ([123I]FP-CIT) binding in patients with Parkinson's disease. For application in routine clinical studies, information on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::9dabf07c13b9ed12e97bd74371caa887
https://pure.amc.nl/en/publications/imaging-of-dopamine-transporters-with-iodine123fpcit-spect-in-healthy-controls-and-patients-with-parkinsons-disease(3ea9f2c3-81d2-4e1b-97f3-28bc10726aad).html

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Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency

Autor: Drukarch, B, Schepens, E, Jongenelen, C A, Stoof, J C, Langeveld, C H

Publikováno v: Brain Research, 770(1-2), 123-30. Elsevier
Drukarch, B, Schepens, E, Jongenelen, C A, Stoof, J C & Langeveld, C H 1997, ' Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency ', Brain Research, vol. 770, no. 1-2, pp. 123-30 .

Astrocytes promote the survival of neurons. Conditions characterized by loss of neurons, such as aging and aging-related neurodegenerative disorders, are accompanied by both disturbances in astrocyte-neuron interactions and signs of oxidative damage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3158ab1b42cc6da2556eecd92916ceab
https://research.vumc.nl/en/publications/a11c360e-1e97-4680-87be-b939e03e5d61

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Anethole dithiolethione prevents oxidative damage in glutathione-depleted astrocytes

Autor: Drukarch, B, Schepens, E, Stoof, J C, Langeveld, C H

Publikováno v: Drukarch, B, Schepens, E, Stoof, J C & Langeveld, C H 1997, ' Anethole dithiolethione prevents oxidative damage in glutathione-depleted astrocytes ', European Journal of Pharmacology, vol. 329, no. 2-3, pp. 259-62 .
European Journal of Pharmacology, 329(2-3), 259-62. Elsevier

Astrocytes protect neurons against reactive oxygen species such as hydrogen peroxide, a capacity which reportedly is abolished following loss of the antioxidant glutathione. Anethole dithiolethione, a sulfur-containing compound which is used in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::257149f1039614505cfef7910801dbc9
https://research.vumc.nl/en/publications/286d5c4a-3446-4fc4-bfa6-34e8412e25dc

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