O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype

Autor: Celso A. Reis, Fátima Gärtner, Joana A. Macedo, Filipe Pinto, Joana Gomes, Diana Campos, Rita Matos, Stefan Mereiter, Marta Pinto, António Polónia, Daniela Freitas, Ana Magalhães

Publikováno v: EBioMedicine

Background: Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d20d0d2b43cb139e5f78f70b5e130f
http://europepmc.org/articles/PMC6413340

CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

Autor: Astrid E. Slagter, Maarten C.C.M. Hulshof, Grard A. P. Nieuwenhuijzen, Edwin P.M. Jansen, Geke A. P. Hospers, Richard van Hillegersberg, Karolina Sikorska, Maartje Los, Donald L. van der Peet, Mark I. van Berge Henegouwen, Hanneke W. M. van Laarhoven, Henk Boot, Nicole C.T. van Grieken, Boudewijn van Etten, Annemieke Cats, Johanna W. van Sandick, Henk H. Hartgrink, Heike I. Grabsch, Marcel Verheij, Laurens V. Beerepoot, Pietje Muller-Timmermans, Frank P. J. Peters

Publikováno v: BMC Cancer, 18(1):877. BioMed Central Ltd
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cancer, 18:877. BMC
BMC Cancer, 18
BMC cancer, 18(1). BioMed Central
BMC Cancer, 18(1). BioMed Central
BMC Cancer
BMC Cancer, 18. BMC
Slagter, A E, Jansen, E P M, van Laarhoven, H W M, van Sandick, J W, van Grieken, N C T, Sikorska, K, Cats, A, Muller-Timmermans, P, Hulshof, M C C M, Boot, H, Los, M, Beerepoot, L V, Peters, F P J, Hospers, G A P, van Etten, B, Hartgrink, H H, van Berge Henegouwen, M I, Nieuwenhuijzen, G A P, van Hillegersberg, R, van der Peet, D L, Grabsch, H I & Verheij, M 2018, ' CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer ', BMC Cancer, vol. 18, no. 1, pp. 877 . https://doi.org/10.1186/s12885-018-4770-2

Contains fulltext : 196889.pdf (Publisher’s version ) (Open Access) BACKGROUND: Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e7b8e7e788dd757dd2f7cc71f3dbf2
https://eprints.whiterose.ac.uk/136426/1/12885_2018_Article_4770.pdf

Chemotherapy for advanced gastric cancer

Autor: Markus Moehler, Wei Peng Yong, Jingshan Ho, Susanne Unverzagt, Wilfried Grothe, Anna Dorothea Wagner, Nicholas Syn, Bee Choo Tai

Publikováno v: The Cochrane Library
The Cochrane database of systematic reviews, vol. 8, pp. CD004064

Background Gastric cancer is the fifth most common cancer worldwide. In "Western" countries, most people are either diagnosed at an advanced stage, or develop a relapse after surgery with curative intent. In people with advanced disease, significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d449a6958393810f646e84962d016c
https://doi.org/10.1002/14651858.cd004064.pub4

Resektion beim fortgeschrittenen Adenokarzinom des Magens und des Ösophagus : Erweiterung der Indikation

Autor: Moenig, Stefan Paul, Schiffmann, L M

Publikováno v: Der Chirurg, Vol. 87, No 5 (2016) pp. 398-405

In den aktuell gültigen deutschen S3-Leitlinien wird bei metastasierten Magenkarzinomen und metastasierten Adenokarzinomen des ösophagogastralen Übergangs eine chirurgische Therapie in der Regel nicht empfohlen. In der täglichen Praxis findet jed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::951ac2fbc6d9a7ef233904fb47964e28
https://archive-ouverte.unige.ch/unige:158697

Evidence of survival benefit of extended (D2) lymphadenectomy in Western patients with gastric cancer based on a new concept: A prospective long-term follow-up study

Autor: Dimitrios H Roukos, M. Lorenz, Albrecht Encke

Publikováno v: Surgery. 123:573-578

Background: The use of extended (D2) lymph node dissection in gastric cancer achieves better locoregional tumor control than limited (D1) lymphadenectomy, but its influence on survival is controversial. The value of D2 resection is unproven in random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e2a4a96bc2adc3a630971c2d01793
https://doi.org/10.1067/msy.1998.88094